Nature Communications
Articles in this Issue
Spatiotemporal molecular tracing of ultralow-volume biofluids via a soft skin-adaptive optical monolithic patch sensor
Molecular basis for the interaction between Saccharomyces cerevisiae Rtt103 and the Rat1-Rai1 complex
Optimization on multifractal loss landscapes explains a diverse range of geometrical and dynamical properties of deep learning
Abstract Gradient descent and its variants are foundational in solving optimization problems across many disciplines. In deep learning, these optimizers demonstrate a remarkable ability to d...
Surface engineering on bulk Cu2O for efficient electrosynthesis of urea
Motion-unrestricted dynamic electrocardiogram system utilizing imperceptible electronics
Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum
Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery
Abstract Cyclic peptides constitute an important drug modality since they offer significant advantages over small molecules and macromolecules. However, access to diverse chemical sets of cy...
Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease
Phase glides and self-organization of atomically abrupt interfaces out of stochastic disorder in α-Ga2O3
Abstract Disorder-induced ordering and remarkably high radiation tolerance in γ-phase of gallium oxide is a recent spectacular discovery at the intersection of the fundamental physics and el...
Predeposited lead nucleation sites enable a highly reversible zinc electrode for stable zinc-bromine flow batteries
Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis
The role of pyruvate dehydrogenase in the lifespan determination of daphnids
K-mer analysis of long-read alignment pileups for structural variant genotyping
Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts
Probing the subtle differences between promethium and curium
Abstract Curium and promethium share similar chemical and physical properties thereby complicating their separation. Co-located processing at Oak Ridge National Laboratory results in...
A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
Abstract Tractable, patient-relevant models are needed to investigate cancer progression and heterogeneity. Here, we report an alternative in vitro model of lung squamous cell carcinoma (LUS...
Role of charges in a dynamic disordered complex between an IDP and a folded domain
Abstract Protein complexes involving intrinsically disordered proteins (IDPs) cover a continuum from IDPs that fully fold upon binding to IDPs that remain fully disordered in the complex. He...
Fingerprints of supersymmetric spin and charge dynamics observed by inelastic neutron scattering
Abstract Supersymmetry is an algebraic property of a quantum Hamiltonian that, by giving every boson a fermionic superpartner and vice versa, may underpin physics beyond the Standard Model....
Optimization and scaling-up of porous solid electrolyte electrochemical reactors for hydrogen peroxide electrosynthesis
Development of N-centered radical scavengers that enables photoredox-catalyzed transition-metal-free radical amination of alkyl pinacol boronates
Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation
A blood- and brain-based EWAS of smoking
Abstract DNA methylation offers an objective method to assess the impact of smoking. In this work, we conduct a Bayesian EWAS of smoking pack years (...
Low melt viscosity enables melt doublets above the 410-km discontinuity
Abstract Seismic and magnetotelluric studies suggest hydrous silicate melts atop the 410 km discontinuity form 30–100 km thick layers. Importantly, in some regions, two layers are observed....
Macroscale-area patterning of three-dimensional DNA-programmable frameworks
The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT
Abstract Classical brown adipose tissue (BAT) is traditionally viewed as relying exclusively on uncoupling protein 1 (UCP1) for thermogenesis via inducible proton leak. However, the physiolo...