Nature Communications
Articles in this Issue
Ensemble refinement of mismodeled cryo-EM RNA structures using all-atom simulations
SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses
Integrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization
Abstract Eliciting a robust immune response against tumors is often hampered by the inadequate presence of effective antigen presenting cells and their suboptimal ability to present antigens...
Dietary lipids are largely deposited in skin and rapidly affect insulating properties
Trait macroevolution in the presence of covariates
Incipient continent formation by shallow melting of an altered mafic protocrust
Tracing human genetic histories and natural selection with precise local ancestry inference
Modulating cortical excitability and cortical arousal by pupil self-regulation
Abstract The brain’s arousal state (i.e., central arousal) is regulated by multiple neuromodulatory nuclei in the brainstem and significantly influences high-level cognitive processes. By ex...
CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles
Fast single metal cation conduction in ion-water aggregated aqueous battery electrolytes
Dynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages
Alternative splicing across the C. elegans nervous system
Tifcemalimab as monotherapy or in combination with toripalimab in patients with relapsed/refractory lymphoma: a Phase I trial
Abstract Preclinical studies of tifcemalimab (anti-BTLA antibody) in combination with toripalimab (anti-PD-1 antibody) demonstrated synergistic anti-tumor effects. We present the outcomes of...
Microbial synthesis of branched-chain β,γ-diols from amino acid metabolism
Reassessing gas generation from oil thermal cracking associated with the Emeishan Large Igneous Province
Deep transcriptomics reveals cell-specific isoforms of pan-neuronal genes
Abstract Profiling alternative splicing in single neurons using RNA-seq is challenging due to low capture efficiency and sensitivity. We therefore know much less...
Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy
Abstract Brain metastases are a frequent and debilitating manifestation of advanced cancer. Here, we collect and analyze neuroimaging of 3,065 cancer patients with 13,067 brain metastases, r...
Regulating obesity-induced osteoarthritis by targeting p53-FOXO3, osteoclast ferroptosis, and mesenchymal stem cell adipogenesis
A self-assembled protein β-helix as a self-contained biofunctional motif
Abstract Nature constructs matter by employing protein folding motifs, many of which have been synthetically reconstituted to exploit function. A less understood motif whose structure-functi...
A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro
Rare earth metals production using alternative feedstock that eliminates HF
Abstract This work reports the successful production of rare earth (RE) metal using Na-RE-F. Presently, RE metals are primarily produced using RE-fluoride due to its higher air and moisture...
Evolutionary origins of self-sustained Kai protein circadian oscillators in cyanobacteria
Chemotactic Zn micromotor for treatment of high blood ammonia-associated hepatic encephalopathy
High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion
Abstract Cohesin-mediated DNA loop extrusion enables gene regulation by distal enhancers through the establishment of chromosome structure and long-range enhancer-promoter interactions. The...