Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy
Abstract
Abstract Brain metastases are a frequent and debilitating manifestation of advanced cancer. Here, we collect and analyze neuroimaging of 3,065 cancer patients with 13,067 brain metastases, representing an extensive collection for research. We find that metastases predominantly localize to high perfusion areas near the grey-white matter junction, but also identify notable differences depending on the primary cancer histology as well as brain regions which do not conform to this relationship. Lung and breast cancers, in contrast to melanoma, frequently metastasize to the cerebellum, hinting at biological pathways of spread. Additionally, the deep brain structures are relatively spared from metastasis, regardless of primary cancer type. Leveraging this data, we propose a probabilistic brain metastasis risk model to enhance the therapeutic ratio of whole-brain radiotherapy by targeting high risk areas while preserving cortical and subcortical brain regions of functional significance and low metastasis risk, potentially reducing the cognitive side effects of therapy.
Article Details
Authors (46)
Jorge Barrios
Evan Porter
Dante P. I. Capaldi
Taman Upadhaya
William C. Chen
Julian R. Perks
Aditya Apte
Michalis Aristophanous
Eve LoCastro
Dylan Hsu
Payton H. Stone
Javier E. Villanueva-Meyer
Gilmer Valdes
Fei Jiang
Michael Maddalena
Ase Ballangrud
Kayla Prezelski
Hui Lin
Jinger Y. Sun
Muhtada A. K. Aldin
Oi Wai Chau
Benjamin Ziemer
Maasa Seaberg
Penny K. Sneed
Jean L. Nakamura
Lauren C. Boreta
Shannon E. Fogh
David R. Raleigh
Jessica Chew
Harish Vasudevan
Soonmee Cha
Christopher Hess
Ruben Fragoso
David B. Shultz
Luke Pike
Shawn L. Hervey-Jumper
Derek S. Tsang
Philip Theodosopoulos
Daniel Cooke
Stanley H. Benedict
Ke Sheng
Jan Seuntjens
Catherine Coolens
Joseph O. Deasy
Steve Braunstein
Olivier Morin