Nature Communications
Articles in this Issue
Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts
Abstract Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene...
Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment
Abstract Single-Molecule Localization Microscopy (SMLM) has traditionally faced challenges to optimize signal-to-noise ratio, penetration depth, field-of-view (F...
scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links
Hexafluorophosphate additive enables durable seawater oxidation at ampere-level current density
Abstract Direct seawater electrolysis at ampere-level current densities, powered by coastal/offshore renewables, is an attractive avenue for sustainable hydrogen production but is undermined...
Structural determinants for pH-dependent activation of a plant metacaspase
Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system
High-performance Ag2Se-based thermoelectrics for wearable electronics
Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations
Early mucosal responses following a randomised controlled human inhaled infection with attenuated Mycobacterium bovis BCG
Abstract The development of an effective vaccine against Mycobacterium tuberculosis is hampered by an incomplete understanding of immunoprotective mechanisms. We utilise an aerosol human cha...
Structures of the Escherichia coli type 1 pilus during pilus rod assembly and after assembly termination
Abstract Uropathogenic Escherichia coli strains use filamentous type 1 pili to adhere to and invade uroepithelial cells. The pilus consists of a flexible tip fibrillum, formed by the adhesin...
Efficient mRNA delivery to resting T cells to reverse HIV latency
Abstract A major hurdle to curing HIV is the persistence of integrated proviruses in resting CD4+ T cells that remain in a transcriptionally silent, latent state. One strategy to eradicate l...
Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition
Synthesis of noble metal nanoarrays via agglomeration and metallurgy for acidic water electrolysis
hpCasMINI: An engineered hypercompact CRISPR-Cas12f system with boosted gene editing activity
Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma
Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection
Abstract Topoisomerase II alpha and beta (TOP2A and TOP2B) isoenzymes perform essential and non-redundant cellular functions. Anthracyclines induce their potent anti-cancer effects primarily...
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
Abstract RNA polymerase II (RNAPII) is a central transcription enzyme that exists as multiple forms with or without accessory factors, and transcribes the genomic DNA packaged in chromatin....
Bioadhesive hydrogel-coupled and miniaturized ultrasound transducer system for long-term, wearable neuromodulation
Interlayer-bonded Ni/MoO2 electrocatalyst for efficient hydrogen evolution reaction with stability over 6000 h at 1000 mA cm−2
Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer
Abstract Packaging in stretchable electronics is crucial to protect components from environmental damage while preserving mechanical flexibility and providing electrical insulation. The conv...
Repeated loss of function at HD mating-type genes and of recombination in anther-smut fungi
GraftIQ: Hybrid multi-class neural network integrating clinical insight for multi-outcome prediction in liver transplant recipients
Chiral dual-annihilator model for controllable photon upconversion and multi-dimensional optical modulation
Contemporary income inequality outweighs historic redlining in shaping intra-urban heat disparities in Los Angeles
Abstract The roots of intra-urban heat disparity in the U.S. often trace back to historical discriminatory practices, such as redlining, which categorized neighborhoods by race or ethnicity....
Anisotropic atom motion on a row-wise antiferromagnetic surface
Abstract Diffusion on surfaces is a fundamental process in surface science, governing nanostructure and film growth, as well as molecular self-assembly, chemical reactions and catalysis. Ato...