Nature Communications
Articles in this Issue
A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones
Abstract J-domain proteins ( JDPs) act as major regulators of the proteostasis network by driving the specificity of the Hsp70 machine. Their important functions are mediated by a lo...
Photochemical C3-amination of pyridines via Zincke imine intermediates
Abstract Selective skeletal and peripheral editing of the pyridine moiety has broadly expanded the chemical space. While C-H functionalization at C2 and C4 positions are enabled by the inher...
Direct evidence of coupling between charge density wave and Kondo lattice in ferromagnet Fe5GeTe2
MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT
Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment
Abstract Infective endocarditis, a life-threatening condition, poses challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its...
Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons
DeepDTAGen: a multitask deep learning framework for drug-target affinity prediction and target-aware drugs generation
Electrochemical deprotonation of halohydrins enables cascading reactions for CO2 capture and conversion into ethylene carbonate
Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy
Abstract Severe immune aplastic anemia is a fatal disease due to the destruction of marrow hematopoietic cells by cytotoxic lymphocytes, serving as a paradigm for marrow failure syndromes an...
Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications
Abstract The tuberculosis (TB) lesion is a complex structure, contributing to the overall spectrum of TB. We characterise, using RNA sequencing, 44 fresh human pulmonary TB lesion sa...
Single-shot two-dimensional nano-size mapping of fluorescent molecules by ultrafast polarization anisotropy imaging
Abstract Molecular size plays a crucial role in determining the physical, chemical, and biological properties of substances. However, traditional fluorescence polarization anisotropy methods...
The barite record of the past seawater oxygen isotope composition
Voltage-controlled magnetoelectric devices for neuromorphic diffusion process
Abstract Neuromorphic diffusion models have become one of the major breakthroughs in the field of generative artificial intelligence. Unlike discriminative models that have been well develop...
Synthesis of chiral germanium center enabled by poly-deborylative alkylation and desymmetrization
Pixel super-resolved virtual staining of label-free tissue using diffusion models
Abstract Virtual staining of tissue offers a powerful tool for transforming label-free microscopy images of unstained tissue into equivalents of histochemically stained samples. This study p...
Short-range order controlled amphoteric behavior of the Si dopant in Al-rich AlGaN
Abstract AlGaN alloys with high Al content offer the possibility to create deep ultraviolet light sources emitting at wavelengths ≤ 240 nm with enhanced quantum...
Asian summer monsoon variability across Termination II and implications for ice age terminations
Abstract The detailed anatomy of Termination I (TI) is well depicted, but whether changes across Termination II (TII) resemble TI remains controversial. Here we present high-resolution Asian...
Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers
Abstract First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are...
Single-cell and spatial transcriptome analyses reveal tumor heterogeneity and immune remodeling involved in pituitary neuroendocrine tumor progression
Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base
Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia
Abstract High-fat diets reshape gut microbiota composition and promote the expansion of Bilophila wadsworthia , a sulfido...
Bayesian deep-learning structured illumination microscopy enables reliable super-resolution imaging with uncertainty quantification
Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes
Abstract Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear. To prioritise cau...
Human endothelial cells promote a human neural stem cell type B phenotype via Notch signaling
Abstract Neural stem and progenitor cell (NSPC) and vessel-forming endothelial cell (EC) communication throughout development and adulthood is vital for normal brain function. However, much...