Nature Communications
Articles in this Issue
Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy
On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis
A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation
Abstract Osteoarthritis is the most prevalent age-related degenerative joint disease and is closely linked to obesity. However, the underlying mechanisms remain unclear. Here we show that al...
WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth
Abstract The lack of curative therapies for acute myeloid leukaemia (AML) remains an ongoing challenge despite recent advances in the understanding of the molecular basis of the disease. Her...
Memristive Bellman solver for decision-making
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly
Abstract NLRP3 is a pattern recognition receptor forming an inflammasome in response to diverse pathogen and self-derived triggers, but molecular insights on NLRP3 activation are still lacki...
Elastocapillary sequential fluid capture in hummingbird-inspired grooved sheets
Abstract Passive and effective fluid capture and transport at small scale is crucial for industrial and medical applications, especially for the realisation of point-of-care tests. Performin...
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
Economic and sustainable revolution to facilitate one-carbon biomanufacturing
Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells
Abstract Targeted kinase inhibitors are a cornerstone of cancer therapy, but their success is often hindered by the complexity of cellular signaling networks that can lead to resista...
Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics
Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models
Coherently confined single-metal-atom chains in 2D semiconductors
Author Correction: Deglacial release of petrogenic and permafrost carbon from the Canadian Arctic impacting the carbon cycle
Interlayer engineering of lattice dynamics and elastic constants of 2D layered nanomaterials under pressure
Expedient access to bora-butenolide bioisosteres by counteranion-mediated trans-hydroboration of alkynes
Abstract The hydroboration of alkynes is a textbook example of a syn-selective concerted addition reaction, while trans-selective additions of borane to alkynes remain to be developed. We he...
Understanding shell coating effects to overcome quenching in single anisotropic upconversion nanoparticles
Regulating orbital interaction to construct quasi-covalent bond networks in Pt intermetallic alloys for high-performance fuel cells
Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling
Abstract Mechanical forces of the tumor microenvironment change dynamically during key events of tumorigenesis such as invasion and metastasis. These changes in compressive forces often affe...
Generating dermatopathology reports from gigapixel whole slide images with HistoGPT
Abstract Histopathology is the reference standard for diagnosing the presence and nature of many diseases, including cancer. However, analyzing tissue samples under a microscope and summariz...
Depletion-dependent activity-based protein profiling using SWATH/DIA-MS detects serine hydrolase lipid remodeling in lung adenocarcinoma progression
Abstract Systematic inference of enzyme activity in human tumors is key to understanding cancer progression and resistance to therapy. However, standard protein or transcript abundances are...
NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon
Abstract Mild periodic acid Schiff staining (mPAS) of human colonic tissue has been used to answer a variety of fundamental questions in germline and somatic genetics. mPAS stains sialic aci...