Nature Communications
Articles in this Issue
Adversarial prompt and fine-tuning attacks threaten medical large language models
Abstract The integration of Large Language Models (LLMs) into healthcare applications offers promising advancements in medical diagnostics, treatment recommendations, and patient care. Howev...
Author Correction: Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD
Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice
Abstract Cryptococcal meningitis is a fungal infection in patients with compromised CD4 T cell function. CD4 T cells provide killing signals to macrophages, principally IFNγ, to limit intrac...
Cellulose-mediated ionic liquid crystallization enables tough-stiff switchable ionogels
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
Abstract Inhibitors of the protein kinase WEE1 have emerged as promising agents for cancer therapy. In this study, we uncover synergistic interactions between WEE1 small-molecule inhibitors...
Global loss of mountain vegetated landscapes and its impact on biodiversity conservation
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback
Abstract Circadian rhythms in gene expression are coincident with 24 hr dynamics in the recruitment of the core-clock transcription factor heterodimer CLOCK-BMAL...
ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis
The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves
Abstract Temporal interference stimulation (TIS) is a promising noninvasive method for neurostimulation, yet its mechanism remains debated. TIS is often described as delivering low-frequency...
Micro-nano microbial fuel cell-driven bioelectrochemical tumor therapy
Programmable material via thiol-ene polymerization initiated by electric-field induced thiyl radical on piezoelectric ZnO
Abstract The spatial and temporal control of material properties at a distance has yielded many unique innovations including photo-patterning, 3D-printing, and architected material design. T...
Publisher Correction: The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses
UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation
Abstract Protein–lipid crosstalk is fundamental to homeostasis in the endoplasmic reticulum (ER). The ER-associated degradation (ERAD) pathway, a branch of the ubiquitin–proteasome system, m...
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
Long-lasting and stable anti-fog coating combined with active and passive strategy
Langmuir-Schaefer deposition of 2D PbS quantum dot superlattices with millimetre square coverage
Ddx61-enriched condensates refine heart regeneration programs
Author Correction: Exome analysis links kidney malformations to developmental disorders and reveals causal genes
Electrically tunable quantum interference of atomic spins on surfaces
Unequal power outages induced by natural disasters
Abstract Natural disasters increasingly threaten energy system reliability. However, little empirical research has examined the unequal impact of such events on power outages. Here, we emplo...
Patterns of genomic deletions in monkeypox virus during the 2022 outbreak in the United States
Abstract Poxviruses have a low overall rate of point mutations but are known to exhibit genomic duplications and deletions that can influence viral evolution. We examine the prevalence of la...
Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1
Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling
Abstract Chemotherapy is often a primary treatment for cancer. However, resistance leads to therapeutic failure. Acetylation dynamics play important regulatory roles in cancer cells, but the...
Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors
Abstract The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an...
The plastid cysteine synthase complex regulates ABA biosynthesis and stomatal closure in Arabidopsis
Abstract Global warming intensifies drought and high light stress periods, causing severe water loss and decreased crop yield. The phytohormone abscisic acid (ABA) is the dominant signal gov...