Nature Communications
Articles in this Issue
Multi-layered dosage compensation of the avian Z chromosome by increased transcriptional burst frequency and elevated translational rates
Abstract Sex-chromosome dosage poses a challenge for heterogametic species in maintaining the proper balance of gene products across chromosomes in each sex. While therian mammals (XX/XY sys...
Soil-dwelling Naegleria enhances plant performance by stimulating beneficial bacterial functions in the rhizosphere
Global geo-hazard risk assessment of long-span bridges enhanced with InSAR availability
Abstract While a geo-hazard risk assessment of bridges is crucial for achieving the United Nations’ Sustainable Development Goals, state-of-the-art methods for evaluation of risk neglect the...
Valence restrictive metal-support interaction for boosting catalytic activity of Rh/CeO2 in CO2 hydrogenation
Author Correction: PAK4 phosphorylates and inhibits AMPKα to control glucose uptake
Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519
Abstract ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymeras...
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes
ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis
Spotting critical point from atomic sites to heterointerfaces on catalysts by oxygen adsorption energy-regulated luminescence
Global disparities in the introduction, scale-up, and effectiveness evaluation of COVID-19 vaccines
Abstract The global response to COVID-19 saw the most rapid and extensive vaccination rollout in history. Yet there were large disparities in the introduction, scale-up, and evaluation of pr...
Room-temperature X-ray fragment screening with serial crystallography
Abstract Structural insights into protein-ligand interactions are essential for advancing drug development, with macromolecular X-ray crystallography being a cornerstone technique. Commonly...
Identifying key uncertainties in energy transitions with a Puerto Rico case study
HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model
Abstract Regulatory T cells (Tregs) hold promise for treating autoimmune disease and transplant rejection, yet generation of autologous products for adoptive transfer can suffer donor variab...
Organic pollutant-induced long-distance ROS signaling drives plant systemic acquired acclimation via rhizomicrobiota
Role of anthropogenic mineral circularity in addressing dual challenges of resource supply and waste management in global photovoltaic development
Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner
Abstract Given that the SARS-CoV-2 virus, and the COVID-19 pandemic, constitutes a major environmental challenge faced by billions of people worldwide, we investigated whether paternal pre-c...
Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure
SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder
Abstract Different types of germline de novo SETBP1 variants cause clinically distinct and heterogeneous neurodevelopmental disorders: Schinzel-Giedion syndrome (SGS, via missense variants a...
Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasion
Sensitive near point-of-care detection of asymptomatic and submicroscopic Plasmodium falciparum infections in African endemic countries
Abstract Limited diagnostic capacity for detecting asymptomatic malaria infections with low parasite densities hinders elimination efforts in Africa. Here, we adapt a near point-of-care, LAM...
Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study
Abstract Cellular senescence, a hallmark of aging, can be quantified by the gene expression composite scores for the canonical senescence pathway (CSP), senescence initiating pathway...
Digitally fabricated 3D slippery architectures for multifunctional liquid manipulation
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family
Abstract Oral vancomycin has a long history as the first-line treatment for Clostridioides difficile infection (CDI), but its use is associated with high relapse rates. Antibiotics that more...