Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

X Xiaomin Ni (Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences) R R. Blake Richardson A Andre Schutzer Godoy M Matteo P. Ferla C Caroline Kikawa (Human Biology Division, Fred Hutchinson Cancer Center) J Jenke Scheen W William W. Hannon E Eda Capkin N Noa Lahav B Blake H. Balcomb P Peter G. Marples M Michael Fairhead S Siyi Wang (State Key Laboratory of Advanced Fiber Materials, Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering) E Eleanor P. Williams C Charles W. E. Tomlinson (Department of Biology, University of York) J Jasmin C. Aschenbrenner R Ryan M. Lithgo M Max Winokan C Charline Giroud I Isabela Dolci R Rafaela Sachetto Fernandes G Glaucius Oliva A Anu V. Chandran M Mary-Ann Xavier M Martin A. Walsh W Warren Thompson J Jesse D. Bloom N Nathaniel T. Kenton A Alpha A. Lee A Annette von Delft H Haim Barr K Karla Kirkegaard (Violetta L. Horton Professor, Departments of Genetics and of Microbiology and Immunology, Stanford University School of Medicine) L Lizbé Koekemoer D Daren Fearon M Matthew J. Evans (School of Chemistry, Monash University, P.O. Box 23, Melbourne, Victoria 3800, Australia) F Frank von Delft