Nature Communications
Articles in this Issue
A brain-to-small intestine circuit mediates morphine-induced constipation in male mice
Abstract Opioid-induced constipation is one of the most common and persistent side effect of opioid analgesics, yet the underlying neural mechanism(s) remain unc...
Active bridging hydride species in ZnO nanorods originated from hydroxyl and oxygen vacancy
Fabrication of low-tortuosity thick electrodes with low material loss by temporally shaped ultraviolet femtosecond laser
BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands
Abstract BAI1, BAI2, and BAI3 (for ‘Brain-specific Angiogenesis Inhibitor-1, -2, and -3’) are adhesion-GPCRs implicated in neuronal development. The precise roles of individual BAIs...
Afterglow ice formed by phosphorescent luminophore-protein conjugates and complexes in aqueous solution at freezing temperature
Abstract Unlike the widely reported fluorophore-biomacromolecule systems in nucleic acid testing and immunoassay, organic afterglow luminophore-biomacromolecule...
AI-guided transition path sampling of lipid flip-flop and membrane nanoporation
Abstract We study lipid translocation (“flip-flop”) between the leaflets of planar lipid bilayers with artificial intelligence (AI) guided transition path sampling (TPS). Rare flip-f...
Room-temperature photoluminescence in monocarboxylate-protected silver nanoclusters via steric hindrance-induced interfacial structure locking
Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice
Resolving forebrain developmental organisation by analysis of differential growth patterns
Abstract The forebrain is the most complex region of the vertebrate central nervous system, and its developmental organisation is controversial. We fate-mapped t...
Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development
Abstract Growth deceleration before growth termination is a universal feature of growth during development. Transcriptomics analysis reveals that during their tw...
Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis
Abstract Cuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxi...
Vibrissae-inspired vision-based magnetic-actuated whisker
Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections
Late-stage adenine N6-alkylation of nucleos(t)ides and oligonucleotides via photoredox and copper co-catalytic decarboxylative C(sp3)–N coupling
Breaking dense integration limits: inverse-designed lithium niobate multimode photonic circuits
Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism
Epitaxial growth of wafer-scale 2D superconductor single crystals by metal-organic chemical vapor deposition
Effectiveness of nirmatrelvir/ritonavir and molnupiravir in reducing the risk of short-term and long-term cardiovascular complications of COVID-19: a target trial emulation study
Abstract While treatment with nirmatrelvir/ritonavir or molnupiravir is effective in lowering the rate of severe COVID-19, the effectiveness of these antivirals in reducing the risk...
Electrochemical dechlorination and hydrocarbon valorization by cobalt phthalocyanine with non-proton-coupled redox property
Intracellularly coupled oscillators for synthetic biology
Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response
Abstract In natural environments, animals encounter pathogen-derived chemicals long before infection occurs. How such anticipatory cues influence extracellular v...
Single cell profiling framework reveals metabolic subpopulations as drivers of bioproduction heterogeneity
Abstract Heterogeneity within clonal cell populations remains a critical bottleneck within bioprocess engineering, notably by undermining bioproduction yields. Efforts to mitigate it...
Overlooked deforestation from global mining activities in the 21st century
Eye movements during free viewing to maximize scene understanding
Abstract What humans look at and do when freely viewing a scene is not well understood. We measure observer eye movements under different instructions while participants view a custo...