Nature Communications
Articles in this Issue
Trait-like visual cortical hyperactivity in trait anxiety
Abstract Sensory processing varies across individuals, with some traits—particularly sensory hypersensitivity to basic non-valenced stimuli—linked to emotional traits and psychiatric...
Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus
Mapping risks of health conditions in people with atopic eczema in English primary care and hospital data
Abstract Atopic eczema may be associated with multiple health conditions. Here, we systematically explore risks across the full health spectrum based on the International Classificat...
Active learning-guided optimization of cell-free biosensors for lead testing in drinking water
Abstract Point-of-use diagnostics based on allosteric transcription factors (aTFs) are promising tools for environmental monitoring and human health. However, biosensors relying on n...
Determinants of sensitivity to HER2-targeted antibody drug conjugates in urothelial cancer
Abstract HER2, encoded by the ERBB2 gene, is a receptor tyrosine kinase frequently activated in human cancers via gene am...
The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD
Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors
Single atom Ru-supported reduced graphene oxide integrated self-assembled monolayer as a nm-scale Cu diffusion barrier
Zinc-oligoether carboxylate salts as electrolyte additives for aqueous Zn metal batteries
Gradient chaotropic regulation of Zn2+ solvation chemistry for low-temperature zinc metal batteries
A Plug-in system for reprogramming the editing patterns of base editors
Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D
Abstract Extrachromosomal DNAs (ecDNAs) are circular DNA molecules prevalent in human cancers that drive tumor evolution and drug resistance. Their circular topology, which disrupts...
Neisseria meningitidis filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants
Abstract Filamentous phages are non-lytic phages mutually beneficial to their bacterial hosts. In Neisseria meningitidis...
Structural basis for the assembly and energy transfer between the cyanobacterial PSI core and the double-layered IsiA proteins
Abstract Iron-limitation is a common stress factor in natural environments. To survive under iron-starved conditions, cyanobacteria overexpress iron stress-induc...
Harnessing multivalency and FcγRIIB engagement to augment anti-CD27 immunotherapy
Abstract Despite significant clinical progress, checkpoint blockade remains limited by variable response rates, resistance, and toxicity. Activating costimulatory receptors offers a...
SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia
Chromosome-level haplotype-resolved assembly of highly heterozygous grass genomes with PhaseGrass
Abstract Current methods to generate haplotype-resolved assemblies for highly heterozygous genomes suffer from reference bias when relying on reference-based pha...
Single iron redox sites boost Methanol-SCR at low temperature
The importance of multiregional accounting for corporate carbon emissions
Abstract Corporations routinely use environmentally-extended input-output models to estimate and report greenhouse gas emissions upstream in their supply chains....