Nature Communications

Risk of major adverse cardiovascular events with aripiprazole versus olanzapine, quetiapine, and risperidone in severe mental illness: a target trial emulation

Alvin Richards-Belle, Naomi Launders, Sarah Hardoon et al. Dec 21, 2025 10.1038/s41467-025-67843-w

Abstract Initiating aripiprazole as antipsychotic monotherapy rather than olanzapine, quetiapine, or risperidone, might prevent/delay major adverse cardiovascular events (MACEs) over...

A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function

Juyeon Hong, Chanjae Lee, Gopika Madhu et al. Dec 21, 2025 10.1038/s41467-025-67086-9

Fruquintinib plus sintilimab in patients with advanced endometrial cancer with mismatch-repair proficient status: a multicenter, single-arm, phase Ib/II trial

Xiaohua Wu, Jing Wang, Danbo Wang et al. Dec 21, 2025 10.1038/s41467-025-67375-3

Neoadjuvant serplulimab combined with chemotherapy for resectable oesophageal squamous cell carcinoma: a single-arm, phase 2 trial

Zixiang Wu, Chuanqiang Wu, Youping Wang et al. Dec 21, 2025 10.1038/s41467-025-67589-5

Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration

Rituraj Marwaha, Diya Manoj, Simran Rawal et al. Dec 21, 2025 10.1038/s41467-025-67645-0

MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells

Alexander H. Clowsley, Anna Meletiou, Radoslav Janicek et al. Dec 21, 2025 10.1038/s41467-025-67801-6

Abstract The cardiac ryanodine receptor (RyR2) constitutes the molecular basis of the process of calcium-induced calcium release where activation of RyR2s can be locally regenerative...

Quantifying the bystander effect of antimicrobial use on the gut microbiome and resistome in Malawian adults

Edward Cunningham-Oakes, Vivien Price, Madalitso Mphasa et al. Dec 21, 2025 10.1038/s41467-025-67677-6

Discovery of high-temperature charge order and time-reversal symmetry-breaking in the kagome superconductor YRu3Si2

P. Král, J. N. Graham, V. Sazgari et al. Dec 21, 2025 10.1038/s41467-025-67881-4

Staphylococcus aureus fatty acid metabolism governs saeRS-mediated aggregation in joint infections

Jinlong Yu, Mingzhang Li, Changming Wang et al. Dec 21, 2025 10.1038/s41467-025-67910-2

TMEM120A maintains adipose tissue lipid homeostasis through ER CoA channeling

Yoon Keun Cho, Junhyuck Lee, Yujin L. Jeong et al. Dec 21, 2025 10.1038/s41467-025-67870-7

Coordination of chromosome segregation and cell division in the archaeon Sulfolobus acidocaldarius

Rachel Y. Samson, Naomichi Takemata, Stephen D. Bell Dec 21, 2025 10.1038/s41467-025-67934-8

Integrating protein language and geometric deep learning models for enhanced vaccine antigen prediction

Xiaodong Zai, Yunxiang Zhao, Xiaolin Wang et al. Dec 21, 2025 10.1038/s41467-025-67778-2

Abstract Vaccines are the most effective tool in preventing and managing infectious diseases. One of the critical challenges in vaccine development is the selection of suitable targe...

Continuous frost causes a greater reduction in forest growth than isolated frost in the Northern Hemisphere

Hongjun Yang, Wenjing Tao, Juan Chen et al. Dec 21, 2025 10.1038/s41467-025-67861-8

Exploring single-cell biosynthetic noise and dynamics for enhanced betaxanthin production in Escherichia coli

Xinyue Mu, Alexander C. Schmitz, Zhenya Ding et al. Dec 21, 2025 10.1038/s41467-025-67733-1

Tracing the origin of myofibroblasts in kidney fibrosis

Shun He, Tianchang Xia, Zhihou Guo et al. Dec 21, 2025 10.1038/s41467-025-67373-5

Investigating action topography in visual cortex and deep artificial neural networks

Davide Cortinovis, Nhut Truong, Hans Op de Beeck et al. Dec 21, 2025 10.1038/s41467-025-67855-6

Abstract High-level visual cortex contains category-selective areas embedded within larger-scale topographic maps like animacy and real-world size. Here, we propose action as a key o...

The cryo-EM structure of Photosystem I from Chromera velia with a bound superoxide dismutase heterodimer

Xukun Yuan, Martin Lukeš, Pu Qian et al. Dec 21, 2025 10.1038/s41467-025-67637-0

Synovial sarcoma reprograms transcription by GBAF activation of polycomb targets and loss of CBAF enhancers

Jinxiu Li, Li Li, Kyllie Smith-Fry et al. Dec 21, 2025 10.1038/s41467-025-67841-y

Abstract Synovial sarcoma is a cancer driven by a fusion oncoprotein, SS18::SSX, that links SS18, a subunit of BAF-family chromatin remodeling complexes, to the carboxy terminus of S...

Decrypting spatiotemporal code of human endometrial receptivity

Yang Liu, Yang Wang, Leilei Zhang et al. Dec 21, 2025 10.1038/s41467-025-67492-z

Evidential deep learning for interatomic potentials

Han Xu, Taoyong Cui, Chenyu Tang et al. Dec 20, 2025 10.1038/s41467-025-67663-y

Simple electronegativity-based model for predicting formation of stable compounds across the periodic table

Artem R. Oganov, Maksim G. Kostenko Dec 20, 2025 10.1038/s41467-025-67658-9

Insights into the self-assembly and interaction of sars-cov-2 fusion peptides with biomimetic plasma membranes

Nisha Pawar, Andreas Santamaria, Brigida Romano et al. Dec 20, 2025 10.1038/s41467-025-67640-5

Abstract First identified in late 2019, the COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, rapidly escalated into a global health crisis. SARS-CoV-2 is a single-stranded RN...

Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential

Minjing Ke, Yuanyue Shan, Ziwei Zhai et al. Dec 20, 2025 10.1038/s41467-025-67651-2

Lithium-ion battery recycling through an integrated electro-membrane crystallization technology

Yan Zhao, Yangbo Qiu, Lei Xia et al. Dec 20, 2025 10.1038/s41467-025-67678-5

Generalizable and scalable protein stability prediction with rewired protein generative models

Ziang Li, Yunan Luo Dec 20, 2025 10.1038/s41467-025-67609-4

Articles in this Issue