Nature Communications
Articles in this Issue
Divergent aging of nulliparous and parous mammary glands reveals IL33+ hybrid epithelial cells
Abstract Aging increases breast cancer risk while an early first pregnancy reduces a woman’s life-long risk. Several studies have explored the effect of either a...
Sugar rationing during the first 1000 days of life and lifelong risk of heart failure
An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression
Abstract Mutations in the extracellular or intracellular domains of epidermal growth factor receptor (EGFR) are implicated in the development of various cancers. While the intracellu...
Neoadjuvant chemoradiotherapy plus sintilimab in proficient mismatch repair locally advanced rectal cancer with intermediate/high-immunoscore (SILAR): a single-arm phase II trial
A stochastic mechanism drives fast substrate translocation in the AAA+ machine ClpB
Abstract How biological machines harness ATP to drive mechanical work remains a crucial question. Structural studies of protein-translocating AAA+ machines proposed a coupled and seq...
In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy
Efficient implementation of a quantum algorithm with a trapped ion qudit
Regulating Pb off-centering distortion for white-light emission in 2D halide perovskites
Retraction Note: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Homogenization of Northern Belgian landscapes through centuries of reclamation, agricultural transition, and urbanization
Serine inhibits granulosa cell ferroptosis to maintain ovarian function
Global alluvial channel patterns
Iterative discovery of potent polymeric antibiotics via multi-stage and multi-task learning against antimicrobial resistance
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle
Abstract In most eukaryotes, the reverse transcriptase telomerase counteracts telomere shortening by processively adding telomeric DNA repeat sequences to chromosome ends. Telomerase...
SNORA49 negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing SOX9 transcription
Impact and cost-effectiveness of doxycycline post-exposure prophylaxis in Australian men who have sex with men
DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains
Abstract Besides genome-wide patterns of replication timing (RT), some genes display allelic replication asynchrony in stem cells, brought about by stochastic ev...
Interfacial engineering via dipolar fullerene derivative for efficient tin halide perovskite indoor photovoltaics
Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions
Abstract Intrauterine adhesions (IUA), a leading cause of female infertility, result from a pathological switch in the uterine injury response from regeneration to fibrotic scarring....
Preventing premature deaths through polygenic risk scores
Women with polycystic ovary syndrome exhibit impaired endometrial receptivity with excessive ERα and histone lactylation
Abstract Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women and severely impairs fertility. Extant clinical studies can only provide indirect...