Nature Communications
Articles in this Issue
The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in mice
Abstract Multiple sclerosis (MS) is a neurodegenerative autoimmune disease primarily mediated by T helper 17 (T H 17) cel...
Automated mapping of DNA replication fork progression in human cells with ForkML
Abstract Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method auto...
Vectorial noncovalent synthesis of bendable organic crystals through dynamic dislocation
A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems
Abstract Extracellular contractile injection systems (eCISs) are bacteriophage tail-derived toxin delivery complexes in prokaryotes. They play roles in microbial...
Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome
Abstract Down syndrome, caused by trisomy 21, affects around six million people worldwide and features learning, memory and language deficits. However, the mecha...
Phosphorothioate DNA modification by BREX type 4 systems in the human gut microbiome
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice
A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor
Abstract The clustering of neurotransmitter receptors at appropriate postsynaptic sites is essential for controlling synaptic transmission. While most known mech...
Scalable and programmable topological transitions in plasmonic Moiré superlattices
Abstract Topological transitions are fundamental phenomena in electronics, photonics, and quantum technologies. However, their scalability and tunability are constrained by material...
Effect of a behavioral counseling for adoption and maintenance of a physically active lifestyle on long-term mortality in people with type 2 diabetes: post hoc analysis of the Italian Diabetes and Exercise Study_2
Breaking the cell wall for efficient DNA delivery to diatoms
Abstract Diatoms produce 20% of the world’s fixed organic carbon yet remain underutilized as cell factories due to limited genetic engineering tools. Here, we pr...
Outsourcing of energetically costly amino acids at the origin of animals
Evaluating single-cell ATAC-seq atlasing technologies using sequence-to-function modeling
Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa
Cross-ancestry comparison of aptamer and antibody protein measures
No evidence of immediate or persistent analgesic effect from a single dose of psilocybin in three mouse models of pain
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
Harnessing PV-oxirene for the modular synthesis of α-Oxy carbonyls
Experimental witness of quantum jump induced high-order Liouvillian exceptional points
Abstract The exceptional point has presented considerably interesting and counterintuitive phenomena associated with nonreciprocity, precision measurement, and topological dynamics....
A bacterial defense system targeting modified cytosine of phage genomic DNA
Abstract The evolutionary arms race between bacteria and phages drives the development of bacterial antiviral defense systems and phage counter-defense strategie...
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina
Abstract Chlamydia pneumoniae is an intracellular bacterium implicated in Alzheimer’s disease (AD), but its role in retinal pathology and dis...
Additive-specific modulation of non-classical nucleation pathways
Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development
Abstract Cardiac outflow tract morphogenesis requires coordinated interactions between multiple cell populations and is dependent on the contribution of cardiac...
Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation
Abstract CD8 + T cells can rapidly produce effector molecules following activation. This activation triggers rapid change...