Nature Communications
Articles in this Issue
3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer
Abstract High-grade serous ovarian cancer (HGSOC) is characterized by a complex, immunosuppressive tumor microenvironment (TME) that contributes to poor clinical outcomes and resista...
Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV)
Abstract CMV seropositivity contributes to medical complications in people living with HIV (PLHIV). This study provides a comprehensive evaluation of how CMV ser...
Indigenous sovereignty and the limits of the Canadian Precision Health Initiative
In-situ revitalizing end-of-life MBR membranes via a curtain-type dynamic membrane process
Abstract Membrane bioreactors (MBR), an industrial mainstay with over 15,000 installations worldwide, face severe sustainability challenges from frequent membran...
Grounding large language models in clinical diagnostics
Bacterial cellulose as a promising biodegradable bioplastic for sustainability
Tazemetostat, an EZH2 inhibitor, in solid tumors harboring SWI/SNF alterations: a phase II basket study
TrialMatchAI: an end-to-end AI-powered clinical trial recommendation system to streamline patient-to-trial matching
Unconventional bipartite entanglement in the quantum dimer magnet Yb2Be2SiO7
Abstract The quantum dimer magnet, with antiferromagnetic intradimer and interdimer Heisenberg exchange between spin-1/2 moments, is known to host an...
Cortex-wide characterization of decision-making neural dynamics during spatial navigation
Chemical bonding manipulation unlocks high performance ionic-bonded thermoelectrics
Solubility based mechanistic profiling of combinatorial drug therapy
Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction
Abstract Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes. In breast cancer, increased tumor stiffness is associated with elevated metastasis r...
Breaking the activity-selectivity trade-off for acetylene semihydrogenation by Pd2 dual-atom site
Functional diversification of WRINKLED3 integrates fatty acid metabolism with insecticidal acylsugar production in Solanaceae species
High-speed graphene-based sub-terahertz receivers enabling wireless communications for 6G and beyond
Achieving sub-pm wavelength regression via minimum-phase in a single-stream photonic IC
Abstract Photonic chips are powerful tools for measuring and analyzing light, but most compact spectrometers face a fundamental trade-off: improving resolution usually requires large...
Ethanol photosynthesis from CO2 and H2O via a formate intermediate pathway
A high-affinity split-HaloTag for live-cell protein labeling
Abstract We introduce a high-affinity split-HaloTag comprised of a short peptide tag (Hpep, 14 residues) and a large, inactive fragment (cpHaloΔ3). Hpep binds to cpHaloΔ3 spontaneous...
Nonaromatic polymer-deep eutectic solvent complexes with ultralong room-temperature and high-temperature phosphorescence
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
Abstract Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic ret...
SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue
Abstract Brown adipose tissue is an evolutionary innovation in placental mammals that regulates body temperature through adaptive thermogenesis. Cold exposure activates brown adipose...
LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC
Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice
A highly energy-efficient multi-core neuromorphic architecture for training deep spiking neural networks
Abstract There is a growing necessity for edge training to adapt to dynamically changing environments. Neuromorphic computing represents a significant pathway for highly efficient in...