LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC
T
Takumitsu Machida
Y
Yingbo Gong
S
Sayaka Tsukioka
A
Atsushi Onodera
A
Akitoshi Nakayama
N
Naoko Hashimoto
T
Takahiro Fuchigami
M
Motoi Nishimura
T
Tomohiro Ogino
R
Ryota Kurimoto
Y
Yasufumi Uematsu
H
Hidemi Suzuki
H
Hongye Yu
M
Mingyang Chen
M
Masataka Yokoyama
I
Ikki Sakuma
(Department of Internal Medicine, Yale School of Medicine)
Y
Yuki Taki
(Department of Molecular Diagnosis, Chiba University Graduate School of Medicine)
T
Takashi Kono
T
Takashi Miki
S
Shinichiro Motohashi
Y
Yusuke Kawashima
(Department of Applied Genomics, Kazusa deoxyribonucleic acid Research Institute)
O
Osamu Ohara
S
Satoshi Yamashita
T
Tatsuya Suzuki
R
Ryo Hatanaka
Y
Yasuo Kodama
S
Shuichi Ohkubo
T
Tomoaki Tanaka
(Department of Molecular Diagnosis, Chiba University Graduate School of Medicine)
Article Details
Journal
Nature Communications
Volume / Issue
Vol. 17, Issue 1
Published
March 25, 2026
ISSN
2041-1723
Publisher
Nature Portfolio
Authors (28)
T
Takumitsu Machida
Y
Yingbo Gong
S
Sayaka Tsukioka
A
Atsushi Onodera
A
Akitoshi Nakayama
N
Naoko Hashimoto
T
Takahiro Fuchigami
M
Motoi Nishimura
T
Tomohiro Ogino
R
Ryota Kurimoto
Y
Yasufumi Uematsu
H
Hidemi Suzuki
H
Hongye Yu
M
Mingyang Chen
M
Masataka Yokoyama
I
Ikki Sakuma
Department of Internal Medicine, Yale School of Medicine
Y
Yuki Taki
Department of Molecular Diagnosis, Chiba University Graduate School of Medicine
T
Takashi Kono
T
Takashi Miki
S
Shinichiro Motohashi
Y
Yusuke Kawashima
Department of Applied Genomics, Kazusa deoxyribonucleic acid Research Institute
O
Osamu Ohara
S
Satoshi Yamashita
T
Tatsuya Suzuki
R
Ryo Hatanaka
Y
Yasuo Kodama
S
Shuichi Ohkubo
T
Tomoaki Tanaka
Department of Molecular Diagnosis, Chiba University Graduate School of Medicine
Related Articles from this Journal
Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization
Chao Wu, Xu Zhang et al.
Aug 2026
10.1038/s41467-026-76516-1
Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses
Connor Weidle, Natalie Brunette et al.
Aug 2026
10.1038/s41467-026-76114-1
Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk
Ludmila Prokunina-Olsson, Oscar Florez-Vargas et al.
Aug 2026
10.1038/s41467-026-76157-4
Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants
Weiwei Jin, Wen Cao et al.
Aug 2026
10.1038/s41467-026-76470-y
Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain
Bongmin Bae, Katherine Gu et al.
Aug 2026
10.1038/s41467-026-76506-3