Nature Communications
Articles in this Issue
Reversible control of post-Golgi transport by brefeldin A reveals recycling endosome maturation during glycosylphosphatidylinositol-anchored protein transport
Abstract Post-Golgi transport plays a crucial role in establishing and maintaining cellular function; however, its mechanism of action remains unclear. Therefore...
Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior
Hydroxy acid conjugation to lipids increases structural and hydrolytic stability
Abstract Contemporary life requires functional polymers and phospholipid-derived compartmentalization. Mutualistic relationships between compartmentalization and polymerization have...
Experimental realization of a bidirectional quantum analog-to-digital converter between photonic wavefront and qubits
Synthetic ion channel inhibitors enhance plant drought tolerance
Abstract Drought stress significantly threatens global food security. According to the FAO2024, agriculture absorbs up to 80% of drought impacts. Stomata are vit...
The Dendritic Cell-based Vaccine PROTEXI leverages Antiviral CD4 T cell Memory to boost anti-tumor immune responses in mice
Personalized Phage Therapy in an ICU Patient with Polymicrobial Pulmonary Infections: a case from a single-arm trial
Immunological maladaptation preceding spontaneous preterm birth in human pregnancies
Abstract The majority of spontaneous preterm births (sPTB) occurs without identifiable clinical indications or apparent risk factors. A dysregulated maternal imm...
SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport
Abstract Membrane transporters and channels are generally assumed to be based on distinct structural and functional principles. SLC26A11, a solute carrier with high expression levels...
Phase locking and multistability in the topological Kuramoto model on cell complexes
Abstract Higher-order interactions fundamentally shape collective dynamics in oscillator networks. The topological Kuramoto model captures these effects by extending synchronization...
Semiconductor room-temperature maser
Abstract We report the first demonstration of a semiconductor maser based on silicon vacancies (V Si ) in 4H-silicon carb...
Central role for fast nociceptors in mechanical nocifensive behavior and sensitization
Abstract Nociceptors, primary afferent nerve fibers that signal noxious stimuli, are broadly divided into slowly conducting unmyelinated C fibers and fast-conducting myelinated A fib...
Substituent-rebound skeletal editing for precise boron-to-carbon single-atom swapping
Abstract Developing methods that enable single-atom exchange within an aromatic scaffold, while preserving its peripheral substitution, represents an important but highly ambitious g...
Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy
Abstract Heart failure is a leading cause of mortality, and impaired cardiac excitation-contraction coupling represents a potentially fatal trigger for myocardia...
Hyperloss from coherent spatial-mode mixing in quantum-correlated networks
Abstract Quantum-correlated networks distribute quantum resources such as squeezed and entangled states. They are central to modern quantum technology, including photonic quantum com...
Upwind terrestrial influences on soil moisture variability across South America
Abstract Soil moisture across South America exhibits coherent spatial patterns shaped by upwind terrestrial conditions, yet their downwind propagation remains poorly quantified. We d...
Synthesis of ZIF-62 Glass and Solid-state Lithium Superconductor Composite Membranes for Electrodialytic Lithium Extraction
JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space
Abstract The antigenic drift of SARS-CoV-2 toward the JN.1 lineage has prompted the development of variant-adapted COVID-19 booster vaccines. However, these boos...
Leiomodin2 is a polymerase at the pointed ends of actin filaments
Thermogenic methane beneath the North Greenland Ice Sheet revealed by isotopic and geological evidence
Abstract Glacial meltwater has been increasingly recognised as a potential source of atmospheric methane, yet its origin and variability in the High Arctic remain poorly constrained....
Place and behavioral modulation of hippocampal neurons during immobility
Abstract Behavioral state fluctuations profoundly impact episodic memory processing. To explore the underlying mechanisms, we recorded CA1 place cells in head-fixed male mice and foc...
Creatinine assay interferences compromises MELD accuracy and may bias liver allocation
Abstract The Model for End-Stage Liver Disease (MELD) score is widely used to prioritize patients for liver transplantation and to estimate short-term mortality in end-stage liver di...
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features
Abstract Cancer arises from genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To chart cancer-intrinsic regulatory pro...
HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination
Abstract R-loops are transcription-induced, three-stranded nucleic acid structures that, if not properly resolved, can disrupt DNA repair and compromise genome stability. BRCA2, a tu...