Nature Communications
Articles in this Issue
A single-cell atlas of porcine hematopoietic development
A NIR fluorotag reporter CETIF6a enables bright pan-tumor labeling and functional proteomic profiling
Abstract Tumor-seeking fluorescent dyes enable precise lesion localization by recognizing overexpressed receptors, providing a critical adjunctive technology for cancer histopatholog...
Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice
Abstract During morphogenesis and in pathological conditions, gaps can form in the plane of epithelial barriers upon cellular forces that disrupt intercellular junctions. How the siz...
A portable Cas6f-based system for multiplex translational repression in bacteria
Delicate inhibition of NFκB/RELA circuitry facilitates efficient transition towards ground-state pluripotency in human
Abstract Rebuilding human naïve pluripotency from primed stem cells is essential for generating pre-implantation epiblast-like cells, a key source for regenerative medicine. Here we...
Learning regularities in noise engages both neural predictive activity and representational changes
Thermodynamically programmed one-pot CRISPR platform for point-of-care SNP genotyping
Abstract One-pot CRISPR diagnostics face a fundamental incompatibility: isothermal nucleic acid amplification enables rapid target accumulation, whereas CRISPR activation irreversibl...
Environment geometry alters sequential route learning and its integration into cognitive maps
Abstract Researchers hypothesize that geometric irregularities can impede spatial memory by distorting neural metrics of space provided by entorhinal grid cells. However, irregularly...
Discovery of potent low-toxicity antimicrobial peptides through diffusion modeling
Abstract The rapid emergence of multidrug-resistant bacteria has created an urgent need for improved antimicrobial discovery and screening platforms. Here, we pr...
IL-6-induced C/EBPα drives follicular regulatory T cell differentiation to regulate humoral immunity in mice
Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis
Abstract Primary sclerosing cholangitis (PSC) is a chronic, progressing cholestatic disease that often co-occurs with inflammatory bowel disease (PSC-IBD). PSC-I...
Large-area two-dimensional MoO3 as a high-κ dielectric for van der Waals integration
Abstract Large-area high-quality dielectrics are essential for the integration of two-dimensional (2D) transistors. However, this integration remains challenging...
Shedding light on bacterial fitness in a tug-of-war with liquid crystal emulsions
Engineering all-organic electrocatalysts with asymmetric dual-active sites for uncommon oxygen-evolving pathway
Meso-electron-withdrawing pentamethine cyanines achieve large anti-Stokes blue-emitting triplet-triplet annihilation upconversion
Two-dimensional pixel-level addressable mid-infrared metasurface spatial light modulator
Abstract Active metasurfaces enable dynamic control of light for applications in beam steering, pixelated holography, and adaptive optics, but demonstrations of two-dimensional elect...
Thermally symbiotic integration of osmotic membrane distillation and electrolysis for direct seawater hydrogen production
Abstract Integrating water purification membranes with electrolysis for in situ hydrogen (H 2 ) production from seawater...
Membrane-anchored DNA nanodevice with allosteric aptamer arms enables parallel probing and on-site drug delivery
Abstract DNA-based molecular computation enables targeting of cells via multiple surface receptors. However, existing platforms are often limited to single-receptor detection per ope...
Spike-based alignment learning solves the weight transport problem
Abstract Learning algorithms are often subject to symmetry constraints that are difficult to reconcile with local computation in physical neuronal networks. For example, contrastive...
Cationic carbon nanotube modulates surface fields for general acidic CO2 reduction with aqueous organic cations
Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1)
Hydrogen bond network disruption enables efficient direct reactive capture of CO2 from flue gas
Declines in organic matter persistence with increased soil carbon
Abstract The persistence of soil organic matter (SOM) is critical for predicting carbon-climate feedbacks, yet how increasing soil organic carbon (SOC) relates to long-term SOM persi...