Nature Communications

E-cadherin inactivation shapes tumor microenvironment specificities in invasive lobular breast cancer

Tailoring light emission in colloidal nanocrystals through lattice distortion engineering

A context-aware artificial metabzyme in intervertebral disc degeneration metabolic convergence therapy

The SIRT3-DsbA-L-TFAM axis restrains cGAS-driven metabolic dysfunction-associated steatohepatitis in male mice

Abstract Whereas mitochondrial dysfunction is implicated in metabolic dysfunction-associated steatohepatitis (MASH), the precise underlying mechanisms remain obs...

T-cell mesenchymal transition represents a potential pathogenic mechanism of female cancer-related lymphedema

Iminium-linked hyperporphyrin covalent organic framework mediates type I photodynamic therapy via a photoredox process

Abstract Most photosensitizers (PSs) mediate type II photodynamic therapy (PDT) via energy transfer to produce singlet oxygen. However, this mechanism is oxygen-dependent and less ef...

Network model for alignment, stitching and slice-to-volume 3D reconstruction of large-scale spatially resolved slices

Single-cell resolution of splicing regulation in peripheral blood mononuclear cells uncovers heterogeneity-driven mechanisms underlying human complex traits

NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis

Abstract Nicotinamide adenine dinucleotide (NAD) is synthesized through both amidated salvage and deamidated pathways. Although NAD-producing enzymes are often overexpressed in cance...