Journal of Clinical Oncology
Articles in this Issue
Tumor-derived extracellular vesicles: A potential novel liquid biomarker for pancreatic ductal adenocarcinoma.
e14551 Background: Extracellular vesicles (EVs) are microscopic particles released by all cell types with a distinct fingerprint reflecting the cell of or...
Updated efficacy and safety results from the phase 2 study of timdarpacept in combination with tislelizumab in patients with classical Hodgkin lymphoma for whom prior anti–PD-1 therapy failed.
7041 Background: Timdarpacept (IMM01), a recombinant SIRPa-Fc fusion protein, can activate macrophages to enhance anti-tumor activity by blocking CD47-SIR...
Building a community-academic partnership to improve clinical trial access in southern Alabama.
e13524 Background: In our efforts to identify and remove barriers to clinical trial enrollment in Alabama, we performed an updated analysis of our communi...
Phase II safety and preliminary efficacy of amulirafusp alfa (IMM0306) in combination with lenalidomide in patients with relapsed or refractory CD20-positive follicular lymphoma.
7051 Background: Amulirafusp alfa (IMM0306) consists of anti-CD20 monoclonal antibody fused with the CD47 binding domain of SIRPα. It exerts potent anti-c...
An open-label single-center investigator-initiated exploratory clinical study in patients with refractory or recurrent solid tumors: R-ISV-FOLactis trial.
2640 Background: Soft tissue sarcomas (STSs) are a highly complex group of tumors and the treatment still remains a challenge. Immunotherapy has become a...
Textbook outcomes after esophagectomy: A five-year of experience at a specialized centre in a developing country.
e16160 Background: A textbook outcome is a distinct measure that promotes better short- and long-term patient outcomes, improves the quality of care at in...
T-cell exhaustion and pre-existing T-cell immunity in circulation as predictive biomarkers for immunotherapy in NSCLC patients.
2553 Background: Pre-existing cancer-antigen specific T-cells describe the endogenous adaptive immunity before any treatment that may represent a valuable...
Financial, social and time toxicity in early-phase cancer clinical trials: The PEARLER study.
11119 Background: Early phase clinical trials (EP-CTs) provide patients with access to novel therapeutics once standard of care options are exhausted or n...
A novel computational approach for survival prediction via fusion of whole-slide images and clinical data.
e15119 Background: Annotations free survival prediction based on whole-slide-images(WSIs) requires diverse semantic information extraction ranging from th...
Efficacy and safety outcomes in patients (pts) with renal impairment in the phase 3 DREAMM-7 and DREAMM-8 trials.
7548 Background: Renal impairment is a frequent complication in relapsed/refractory multiple myeloma (RRMM). Results from DREAMM-7 (NCT04246047) showed si...
A large language model (LLM)-based multi-agent framework for risk stratification and treatment recommendations in localized prostate cancer (locPCa).
5108 Background: We previously proposed a hybrid framework combining LLMs and rule based algorithm (RBA) for automating risk stratification in locPCa. Her...
Comparison of predictive models in women with advanced epithelial ovarian cancer triaged to primary debulking or neoadjuvant chemotherapy.
5547 Background: Triaging women with advanced epithelial ovarian cancer (AEOC) into primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) rem...
Niraparib plus PD-1 inhibitor for patients previously treated with immune checkpoint inhibitor for solid tumors with homologous recombination repair gene mutation (IMAGENE): A phase II basket study.
2613 Background: Prior clinical trials have established the effectiveness of poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) or immune checkpoint in...
Strategies to achieve racial equity in cardio-oncology care for women with ovarian cancer.
e24028 Background: Ovarian cancer (OC) remains the most lethal gynecologic malignancy, despite significant advancements in treatment that have led to impr...
A monocentric analysis of ESCAT gene actionability detection in non-specific molecular profile (NSMP) endometrial cancer.
e17634 Background: The non-specific molecular profile (NSMP) subtype accounts for 50% of endometrial carcinoma (EC). It's a heterogeneous group of tumors,...
Irinotecan liposome combined with anlotinib as second-line treatment in patients with small cell lung cancer (SCLC).
e20105 Background: Irinotecan is one of the options for the second-line treatment of SCLC. Liposomal irinotecan can specifically target tumor areas due to...
Real-world treatment patterns in patients with metastatic bladder cancer: A cross-regional analysis.
e23321 Background: Approximately 5% of patients are diagnosed with metastatic bladder cancer (mBC), and about half relapse after cystectomy. The treatment...
Estimating the access to psychotherapy and psychological support for cancer patients in Nigeria: A national study.
e24068 Background: Cancer is a leading cause of psychiatric disorders, including depression, anxiety, delirium, distress, sexual dysfunction, and sleep di...
A multi-level qualitative exploration of factors influencing breast and cervical cancer screening uptake in Nepal.
e13858 Background: The global cancer burden disproportionately impacts low- and middle-income countries. In Nepal, breast and cervical cancer are the two...
Understanding tobacco use and cessation challenges amongst patients with lung cancer: Elucidating demographics and the role of social networks.
e22612 Background: Continued use of combustible tobacco after lung cancer diagnosis leads to worse morbidity and mortality. Unfortunately, smoking prevale...
Risk assessment and development of a machine learning–based prediction model for survival in patients with medulloblastoma.
10061 Background: While clinical risk factors have long guided medulloblastoma (MB) treatment, the significance of genetic events in therapeutic strategie...
First-in-human study of BG-C9074, a B7-H4-targeting ADC in patients with advanced solid tumors: Preliminary results of the dose-escalation phase.
3033 Background: B7-H4 is a transmembrane glycoprotein in the B7 superfamily with limited expression in normal tissue but is upregulated in solid tumors i...
Use of PD-1/PD-L1 inhibitors in non-small cell lung cancer in elderly patients: A meta-analysis.
e20558 Background: Non-small cell lung cancer (NSCLC) is considered a significant health concern due to its high prevalence and frequently diagnosed at an...
The use of circulating tumor DNA (ctDNA) to evaluate need for additional targeted therapies in HER2 positive metastatic breast cancer (MBC).
e13003 Background: HER2+ MBC is an aggressive form of breast cancer. There have been significant advances in HER2 targeted therapies, but progression free...
Endoscopic submucosal dissection with adjuvant chemotherapy for early gastric cancer: Unnecessary complexity or added benefit? A real-world data analysis.
e16132 Background: Endoscopic submucosal dissection (ESD) has become a standard treatment for early gastric cancer (EGC), offering high en bloc resection...