Journal of Clinical Oncology
Articles in this Issue
Effects of malnutrition on cardiovascular outcomes in malignant melanoma patients treated with pembrolizumab: A global propensity score-matched cohort study.
e21530 Background: Malnutrition is a well-recognized risk factor for poor outcomes in cancer patients. This study investigates the impact of malnutrition...
Impact of standard vs reduced dosing of sotorasib on efficacy and toxicity in KRAS G12C–mutated advanced non-small cell lung cancer: A systematic review and meta-analysis.
8593 Background: KRAS is the most common oncogenic driver in lung adenocarcinoma. Advances in targeted therapies such as Sotorasib have improved outcomes,...
Gastric cancer incidence in Mongolia: A clinical and molecular pathological study.
e16101 Background: Gastric cancer (GC) tends to be different in populations and our previous study showed that 66.6% of all early GCs are in cardia, which...
Teledermatology-dermoscopy: Expanding access to skin cancer screening to reduce healthcare disparities.
1653 Background: Skin cancer, the most common malignancy in the United States, continues to rise in incidence. Underserved populations face significant ba...
Temporal trends in opioid prescription fills following cancer-directed surgery.
11099 Background: Postoperative pain is a common complication of cancer surgery. Opioid prescribing has declined dramatically since the early 2010’s; howe...
Comparison of outcomes between open and minimally invasive hepatic resections for hepatocellular carcinoma: A retrospective analysis.
4110 Background: Recent data from the United States indicate that the incidence of hepatocellular carcinoma (HCC) has tripled over the past 40 years, with...
Association of resting mast cell infiltration in the sarcoma microenvironment with overall survival.
e14564 Background: Sarcoma remains a challenging solid cancer to treat in the modern era. The role of mast cells in the tumor microenvironment continues t...
The impact of food and drug administration-based eligibility criteria on demographic representation in current phase III clinical trials for newly diagnosed breast cancer.
e23021 Background: Restrictive eligibility criteria may limit demographic representation in clinical trials. Beginning in 2020, the US Food and Drug Admin...
Camrelizumab plus apatinib in patients with advanced or refractory chordoma: A single-arm, open-label, phase 2 trial.
11503 Background: The limited efficacy of current treatments for chordoma underscores the need for novel therapeutic optio...
Chemotherapy-induced peripheral neuropathy in breast cancer: Prevalence and predictors in an Indian tertiary care center.
e23201 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect associated with the use of neurotoxic agen...
Trial in progress: TAGGED—A phase 2 study using low dose/metronomic trabectedin, gemcitabine, and dacarbazine as 2 <sup>nd</sup> /3 <sup>rd</sup> /4 <sup>th</sup> line therapy for advanced soft tissue sarcoma (NCT04535271).
TPS11589 Background: Despite significant progress in the field of cancer medicine, the prognosis of advanced soft tissue sarcoma (STS) patients remains po...
Patient-derived method for rapidly constructing cervical organoids with native immune and mutation profiles.
e17531 Background: Persistent infection with high-risk human papillomavirus(HR-HPV), particularly HPV16, is a major risk factor for the development of cer...
Integrated immune profiling approach for immuno-oncology: Unveiling biomarkers and therapeutic targets with mass cytometry.
e14575 Background: Over the last decade, immunotherapy has revolutionized cancer treatment, offering transformative outcomes for many patients. However, i...
Prognostic and predictive impact of the baseline systemic proteome in patients with <i>RAS</i> wild-type metastatic colorectal cancer: Analysis from the randomized phase II PanaMa (AIO KRK0212) trial.
3546 Background: Systemic proteomics offers a minimally invasive approach to identifying biomarkers in metastatic colorectal cancer (mCRC). This study ana...
ctDNA features of acquired resistance to immunotherapy in advanced NSCLC.
2563 Background: Acquired resistance to systemic therapies, including immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs), is a majo...
EVEREST-2: Initial data of the logic-gated Tmod chimeric antigen receptor T-cell (CAR T) therapy A2B694 for patients with solid tumors associated with mesothelin (MSLN) expression and with human leukocyte antigen (HLA) loss of heterozygosity (LOH).
3040 Background: EVEREST-2 is a first-in-human, phase 1/2 trial to assess the safety and efficacy of A2B694, an autologous, logic-gated Tmod CAR T therapy...
Racial and socioeconomic disparities in colorectal cancer incidence following bariatric surgery: A retrospective analysis (2009–2022).
e15634 Background: Obesity is a major modifiable risk factor for cancer and is associated with increased colorectal cancer (CRC) incidence and mortality....
Functional and survival outcomes in HPV positive oropharyngeal squamous cell cancer treated with response-adaptive de-escalation: A pooled analysis.
6068 Background: Human papillomavirus (HPV) positive OPSCC is known to have a favorable prognosis compared to its HPV negative counterparts. It is thus im...
Breaking barriers: Upfront expense payments to ease the economic burden for clinical trial patients.
e23160 Background: Participation in clinical trials (CT) often imposes significant challenges on patients, beyond emotional and time commitments. The econ...
MCT1-mediated histone lactylation modulates lung cancer cell sensitivity to T-cell–mediated killing by influencing mitochondrial dysfunction.
e20051 Background: Histone lactylation, a newly identified epigenetic modification, has been extensively implicated in the initiation and progression of t...
A multi-center retrospective outcomes analysis of patients with localized synovial sarcoma.
e23555 Background: Synovial sarcoma (SS) is a rare and aggressive form of soft tissue sarcoma which disproportionately affects younger individuals. Optima...
Network pharmacology analysis of phytochemicals in targeting cancer: A systems biology approach.
e15130 Background: The intricate nature of cancer necessitates an integrative approach to uncover novel therapeutic strategies. Phytochemicals derived fro...
Effects of cancer medications shortage on the survival of patients with lung cancer: A multicenter study in Lebanon.
e20540 Background: Globally, lung cancer remains the leading cause of cancer-related deaths despite the fact that its treatment has evolved tremendously w...
PD-L1 expression on circulating tumor cells and CTC clusters as a minimal cellular disease in breast cancer patients.
e15036 Background: Tumor-transitioned components, for example, dual biomarkers like ctDNA and circulating tumor cells (CTCs) offer true comprehensive prec...
Solid tumor–specific patterns of immune-related adverse events due to immune checkpoint inhibitor.
2648 Background: Immune checkpoint inhibitors (ICIs) are the backbone of therapy for several solid tumors; however, they have a unique toxicity profile th...