Journal of Clinical Oncology
Articles in this Issue
Comprehensive decision support tool (DST) in breast cancer: Automated National Comprehensive Cancer Network (NCCN) guidelines linked to living systematic literature review (SLR).
e13676 Background: An SLR of interventional clinical trials projects > 7,500 publications in 2024, alongside > 6 NCCN updates and numerous FDA appro...
Final clinical and molecular analysis of the EORTC randomized phase III intergroup CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q codeletion: NCT00626990.
2002 Background: The 1st and 2 nd interim analyses of the CATNON trial on anaplast...
The differential effect of stromal genes on gemcitabine/nab-paclitaxel (GN) and GN/cisplatin (GCN) outcomes in advanced pancreatic adenocarcinoma (aPDAC).
4166 Background: GN is a front-line therapy for aPDAC. A Phase I/II study demonstrated that GCN has a higher overall response rate and median overall surv...
Real-world safety and effectiveness of trastuzumab deruxtecan (T-DXd) in HER2-overexpressing malignancies: A single-center retrospective study.
e15577 Background: HER2-overexpressing cancers represent a distinct group of malignancies. Based on the DESTINY-PanTumor02 trial, the FDA recently approve...
Heterogeneity in epithelioid hemangioendothelioma (EHE): Insights into common and organ-specific tumor pathways.
11565 Background: EHEs are ultra-rare sarcomas that can arise from various organs, with the primary site being an important prognostic factor. We hypothes...
Genomic landscape of lung cancer in India: Insights from a precision oncology perspective.
e20080 Background: Lung cancer is the second most common cancer with a high mortality rate. Understanding its genomic landscape is crucial for identifying...
Impact of BMI on CDK4/6 inhibitors efficacy and safety in advanced breast cancer: Results from a propensity score matched study—CAMELIA.
1058 Background: Body mass index (BMI) is strongly associated with the development and progression of breast cancer. Despite the widespread use of cyclin-...
Association between prostate radiation therapy and survival among patients with metastatic prostate cancer by extent of disease burden.
e17123 Background: Because of improved oncologic efficacy, external beam radiotherapy (RT) is increasingly used in men with metastatic hormone-sensitive p...
Racial differences in serious immune-related adverse events among cancer patients receiving immune checkpoint inhibitors.
1621 Background: Immune checkpoint inhibitors (ICIs) are associated with an increased risk of adverse events (irAEs). We a...
Differences in insurance status among Asian Americans with cancer: A disaggregated analysis by ethnic subgroup.
1529 Background: Asian Americans, the fastest-growing racial/ethnic group in the U.S., experience significant variation in barriers to cancer care access,...
A retrospective observational analysis examining liquid biopsies with tissue biopsies in patients with advanced non-small cell lung cancer.
e15049 Background: Non-small cell lung cancer (NSCLC) is genetically diverse, harboring mutations targetable with FDA-approved therapies. Identifying acti...
Geographic, racial and temporal disparities in cancer and respiratory failure mortality in the US: A 24 year retrospective study.
e20520 Background: Cancer and respiratory failure (RF) are amongst leading causes of mortality in adults. This study investigates national trends in age-a...
Strategic efforts for optimal outcomes in patients with low anterior resection syndrome (LARS) at the Vanderbilt-Ingram Cancer Center (VICC).
e15643 Background: Low anterior resection (LAR) involves surgical resection of the rectum while sparing the anal sphincter and is frequently performed for...
Post hoc analysis of rashes reported in patients (pts) with <i>BRAF</i> -altered relapsed/refractory (r/r) pediatric low-grade glioma (pLGG) treated with the type II RAF inhibitor tovorafenib in FIREFLY-1.
10037 Background: Targeted therapies have become a mainstay in the treatment of pLGG. While effective, toxicities, including cutaneous adverse events (AEs...
Effect of IV magnesium supplementation in reducing adverse cisplatin associated kidney outcomes.
12123 Background: Cisplatin is a commonly used chemotherapy agent that is associated with significant nephrotoxicity due to renal tubular cell injury. IV...
A phase 2 study of pemigatinib for pre-treated glioblastoma or other gliomas with activating FGFR1-3 alterations: Results from FIGHT-209.
2003 Background: FGFR genomic alterations occur in approximately 8% of gliomas. Inhibition of FGFR1-3 with pemigatinib sho...
Targeting HER3 in NSCLC: Leveraging continuing education to bridge the gaps between evidence and practice.
e20055 Background: Treatments that target human epidermal growth factor receptor 3 (HER3) are emerging options for managing patients with non-small cell l...
Linvoseltamab (LINVO) + bortezomib (BTZ) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): First results from the LINKER-MM2 trial.
7510 Background: LINVO, a BCMA×CD3 bispecific antibody, has shown high efficacy and generally manageable safety in triple-class exposed (TCE: anti-CD38 Ab...
Assessing the impact of policy implementations on treatment duration for patients with locally advanced cervical cancer in a northern province of Argentina.
e23135 Background: Cervical cancer represents a public health challenge in low and middle-income countries (LMIC). Instituto Misionero del Cancer (IMC) is...
A retrospective analysis of metaplastic triple negative breast cancer response to sacituzumab govitecan and candidacy for targeted therapy.
e13015 Background: Metaplastic breast cancer (MpBC) is a rare, histologically distinct form of breast cancer. Around 90% of MpBC is negative for estrogen...
Association of county-level medical debt and timely treatment initiation among individuals newly diagnosed with cancer.
11077 Background: Medical debt is associated with adverse cancer outcomes, including poor survival. However, it is unknown if living in a county with high...
Molecular characteristics, treatment patterns, and survival outcomes in biliary tract cancers: A retrospective analysis from a high-prevalence region.
4109 Background: Biliary tract cancers (BTC) present significant challenges in management due to their aggressive nature and often late-stage presentation...
Efficacy of Chinese medicine compound Fufang E’jiao Syrupfor symptom burden of cancer-related fatigue in patients with advanced cancer: A randomized clinical trial.
12070 Background: Cancer-related fatigue ( CRF) is often accompanied by a high symptom burden, significantly impacting the quality of life in...
Postoperative assessment using urinary tumor DNA (utDNA) to identify potential candidates for repeat transurethral resection of bladder tumor (re-TURBT) in non-muscle invasive bladder cancer (NMIBC): A retrospective analysis.
4587 Background: The role of routine repeat transurethral resection of bladder tumor (re-TURBT) in managing non-muscle invasive bladder cancer (NMIBC) rem...
Mutational spectrum of cell proliferation genes as early predictive markers for aggressive disease in endometrial cancers.
e15034 Background: Endometrial cancer (EC) illustrates diverse nucleotide substitution and chromosomal re-arrangement signatures like other cancers. Namel...