Journal of Clinical Oncology
Articles in this Issue
Integrating dynamic analysis of serial ctDNA testing to enhance diagnostic and prognostic assessments in patients with metastatic breast cancer.
1042 Background: The monitoring of circulating tumor DNA (ctDNA) in patient with metastatic breast cancer (MBC) plays a critical role in predicting therap...
Sociodemographic differences in lung cancer mortality trends across the United States (US) rural-urban divide.
11048 Background: It is known that rural populations face higher lung cancer mortality than urban populations, but it is u...
Circulating tumor DNA (ctDNA) analysis for improved treatment response assessment and prediction of clinical outcomes in patients with esophageal cancer.
4077 Background: Despite curative-intent treatment, patients with esophageal cancer experience a high risk of recurrence, and optimal patient management i...
A generative model for the design of novel inhibitors targeting the PD-1/PD-L1 pathway.
2576 Background: The programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) signaling pathway plays a pivotal role in tumor immunosuppression...
Comprehensive molecular analysis of phase IB/II trial of durvalumab plus doxorubicin combination in patients with advanced soft-tissue sarcoma.
11555 Background: We conducted an open-label, phase IB/II study to determine the activity and safety of the standard-of-care, doxorubicin in combined with...
Outcomes with CDK4/6 inhibitor in metastatic hormone receptor–positive breast cancer: Insights from a tertiary care centre in India.
e13086 Background: Cyclin dependant kinase 4/6 inhibitors (CDKi), along with endocrine therapy (ET), is the first line management of metastatic hormone re...
Impact of psychological intervention on perceived distress of cancer patients: Results from a longitudinal study in India.
e24062 Background: Despite the psychological impact of cancer being a well-established entity, it is often not prioritised in low to middle-income nations...
Unmet need in adults and adolescents and young adults (AYAs) with B-cell acute lymphoblastic leukemia (B-ALL) in the US following a second relapse.
e18510 Background: While new treatment modalities, such as the bispecific T-cell engager blinatumomab (blin) and chimeric antigen receptor modified T-cell...
Phase Ib trial of C019199, an oral TME modulator targeting CSF-1R/DDRs/VEGFR2, in relapsed or refractory osteosarcoma.
11510 Background: C019199 is an oral drug candidate that modulates the tumor micro-environment (TME) through targeting CSF...
Financial toxicity in cancer care: Experience from a tertiary care cancer center.
e23199 Background: Financial toxicity (FT) is associated with poor quality of life (QOL) and survival and is a well-recognized, critical issue for cancer...
Real-world outcomes by DNA mismatch repair (MMR) status in patients (pts) with high-risk endometrial cancer (EC) in the adjuvant setting.
e17623 Background: EC is the sixth most common cancer in women. Pts with high-risk EC are more susceptible to recurrence. Per ESMO guidelines, high-risk s...
The preliminary safety results of an observational phase II study of concurrent use of aspirin with dabrafenib and trametinib in BRAF V600 NSCLC.
e20632 Background: Dabrafenib combined with trametinib (DabTram) is highly effective in treating BRAF V600-mutant non-small cell lung cancer (NSCLC). Howe...
A large centre study of pathological and clinical characteristics of signet ring and mucinous colorectal adenocarcinomas.
e15672 Background: Colorectal carcinoma is a rapidly growing public health problem worldwide. In India, a historically low prevalence country, rates have...
Drug-eluting beads loaded with irinotecan-transarterial chemoembolization (DEBIRI-TACE) combined with hepatic artery infusion chemotherapy and regorafenib in colorectal liver metastases refractory to second-line and above standard systemic therapy: A single-center, phase II clinical trial (DREAM).
3539 Background: For patients with colorectal liver metastasis (CRLM) who have failed in first-line or second-line systemic treatment, the prognosis is ex...
Comparison of artificial intelligence to expert physician assessments of real-world oncology cases.
1564 Background: Artificial intelligence (AI) is increasingly being incorporated into the oncology field as a tool to support clinical decisions. AI tools...
Results from a phase 1/2 study of 7MW3711: A novel B7-H3 antibody-drug conjugate (ADC) incorporating a topoisomerase I inhibitor in patients with lung cancer.
3036 Background: 7MW3711 is a B7-H3 targeting ADC comprised of a recombinant humanized monoclonal anti-human B7-H3 antibod...
Real-world outcomes for dMMR/MSI-H colorectal cancer: Navigating rapidly evolving oncologic practices in a community hospital.
e15519 Background: The incidence of Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Colorectal Cancer (CRC) is 15% among all CRCs...
SALVOVAR: A pragmatic randomized phase III trial comparing the salvage weekly dose-dense regimen to the standard 3-weekly regimen in patients with poor prognostic ovarian cancers (GINECO-OV130b; ENGOT-ov78).
TPS5626 Background: The patients with an advanced epithelial ovarian cancer (EOC) treated with a neo-adjuvant platinum-based chemotherapy who are not amen...
Risk factors and causes of early death among patients with germ cell testis tumors (GCTs): An international collaborative study supported by the Global Society of Rare Genitourinary Tumors.
5030 Background: GCTs are the most common solid tumor in young men aged 20 to 40 years and are curable in most cases. However, a small proportion of patie...
The optimized HLH inflammatory index: A novel prognostic tool for newly diagnosed patients with diffuse large B-cell lymphoma—Discovery and validation.
7073 Background: The Optimized HLH Inflammatory (OHI) index (Zoref-Lorenz et al., Blood , 2022), based on serum soluble CD25 (sCD2...
Combined impact of patients and disease characteristics on survival outcome in early hormone receptor negative patients across SBR grades.
e12525 Background: Previous studies have established a correlation between Scarff-Bloom-Richardson (SBR) grades, cell proliferation, and chemo-response in...
Evaluating the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) as an adjunct to surgery for advanced ovarian cancer: A systematic review and meta-analysis of randomized controlled trials.
e17579 Background: Advanced ovarian cancer remains a significant challenge in gynecologic oncology, with a 5-year survival rate of approximately 30% for p...
Immunotherapy making inroads into advanced endometrial cancer management: A single center real world experience.
e17635 Background: Chemotherapy with carboplatin and paclitaxel was the standard treatment for advanced endometrial cancer (EC) for many years. In recent...
High-dose furmonertinib combined with bevacizumab and pemetrexed in non-small cell lung cancer patients with <i> <i>EGFR</i> </i> mutations and leptomeningeal metastasis: A prospective real-world study.
8609 Background: Leptomeningeal metastasis (LM) in lung cancer is always associated with poor prognosis. Our previous study has demonstrated that high-dos...
Hyperthermic intraperitoneal chemotherapy in recurrent ovarian cancer: An updated systematic review and meta-analysis.
5584 Background: Ovarian cancer is the leading cause of mortality among gynecological malignancies in women. Disease recurrence remains a formidable chall...