Journal of Clinical Oncology
Articles in this Issue
The treatment patterns and adverse reactions of bevacizumab in the Chinese population in the real world.
e23267 Background: Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor (VEGF), which can be used to treat many types of canc...
Progressive NK cell dysfunction and ILC imbalance as drivers of immune evasion in multiple myeloma.
e19557 Background: Innate lymphoid cells (ILCs), including Natural killer (NK), exhibit distinct phenotypic and functional changes during multiple myeloma...
Change in T2-weighted signal intensity, change in tumor volume, and exposure-response analysis in the RINGSIDE phase 2 study of varegacestat in patients with desmoid tumors.
11557 Background: T2-weighted signal intensity (T2W) and tumor volume (TV) on MRI may be more sensitive than RECIST for assessing treatment effect in desm...
The hidden toll: Defining impacts of home call on oncology fellows.
9021 Background: Home call is an expected trainee responsibility in many hematology-oncology (HO) training programs although the specific duties and frequ...
Opinions of real-world clinicians on endocrine resistance in HR+/HER2- mBC: Results from the RETRACT survey of US oncologists.
e13064 Background: Endocrine therapy (ET) is the treatment of choice in patients with metastatic breast cancer (mBC), but the benefit is limited by the in...
Allogeneic hematopoietic cell transplantation for acute leukemia patients not in complete remission.
6553 Background: Current guidelines support allogeneic hematopoietic cell transplantation (allo-HCT) in patients with acute leukemia who achieve complete...
From food deserts to clinical trial deserts: Challenges in access to breast cancer trials.
1525 Background: Patients who live in food deserts have high mortality rates from breast cancer and stand to benefit from participating in research studie...
Maintaining momentum in cancer health equity: Examining Native Hawaiian and Pacific Islander US cancer mortality trends (1999-2024) and mechanisms for enhancing representation in oncology clinical trials.
e23327 Background: Native Hawaiian and Pacific Islanders (NHPI) face higher cancer mortality rates compared to White people, with a 75% increased likeliho...
Pertuzumab plus trastuzumab (P+T) in patients (pts) with bladder (BC) and ovarian cancer (OC) with <i>ERBB2/3</i> alterations (alt): Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) study.
3126 Background: TAPUR is a phase II basket study evaluating antitumor activity of commercially available targeted agents in pts with advanced cancers wit...
A phase II study of the interleukin-6 (IL-6) receptor blocking antibody sarilumab (Sari) in combination with ipilimumab (Ipi), nivolumab (Nivo) and relatlimab (Rela) in patients with unresectable stage III or stage IV melanoma.
9510 Background: Combination immune checkpoint inhibitor regimens, especially those utilizing anti-CTLA-4 blockade, demons...
The effect of patient self-reported confidence on psychosocial outcomes in the context of lymphoma and chronic lymphocytic leukaemia.
7074 Background: Adverse psycho-social outcomes (APSO’s) are common side effects often underreported which have great impact on the wellbeing of patients...
Overall survival with fruquintinib versus placebo after adjusting for subsequent anticancer therapy in patients with refractory metastatic colorectal cancer in the FRESCO-2 study.
e15568 Background: Fruquintinib is a highly selective, oral inhibitor of all 3 vascular endothelial growth factor receptors (VEGFRs -1, -2, and -3) that i...
Hyperlipidemia as adverse event of lorlatinib, a multicenter cohort study.
e24040 Background: Lorlatinib, a third-generation tyrosine kinase inhibitor targeting ALK mutations, has shown superior efficacy in patients with advanced...
A novel device to simultaneously collect standard core biopsies and dislodged cancer cells from solid tumors for molecular testing.
e13898 Background: The molecular profiling of breast cancer is becoming an integral component of patient care. Routine pathology lab processing creates ba...
Trends and disparities in diffuse large B-cell lymphoma mortality among older adults in the United States (1999-2020): A CDC WONDER database analysis.
e13734 Background: Despite treatment advancements, diffuse large B-cell lymphoma (DLBCL) remains a significant public health concern. This study evaluates...
Detection of early-stage colorectal cancer using multiplexed extracellular vesicle proteomic biomarkers.
3616 Background: Colorectal cancer (CRC) is very common worldwide, and detection of early-stage cancer is critical for improved survival rates. Advanced a...
Multimodal machine learning predictions of treatment response and survival in advanced pancreatic cancer from the COMPASS trial.
4181 Background: Pancreatic cancer is an aggressive malignancy with limited therapeutic options and a poor prognosis. Curr...
HBV-TCR T cell therapy: Preclinical and clinical insights into specificity, safety and efficacy for treating HBV-related HCC.
e14525 Background: LioCyx-M, an autologous T-cell therapy modified with mRNA encoding HBV-specific TCRs, was developed using a TCR selected from a proprie...
Analysis of readmission rates, length of stay and mortality among bone marrow transplant and CAR-T patients in a rural state.
e19021 Background: Bone marrow transplantation (BMT) and chimeric antigen receptor T-cell (CAR-T) therapy has become an integral treatment modality for se...
AI for evidence-based treatment recommendation in oncology: A blinded evaluation of large language models and agentic workflows.
e13656 Background: Evidence-based medicine is crucial for clinical decision-making, yet studies suggest that a significant proportion of treatment decisio...
Systemic mastocytosis: A study of trends, survival and second primary malignancies among adults in the United States.
e18597 Background: Systemic mastocytosis is a rare hematologic disorder characterized by the clonal proliferation and accumulation of aberrant mast cells...
Exploring unmet needs in radiation-induced nausea and vomiting after moderately emetogenic treatment.
12124 Background: Despite their prevalence and clinical significance, interventions to improve radiation-induced nausea and vomiting (RINV) are insufficie...
Proteogenomic characterization of antibody-drug conjugate target expression profiles in transcriptional subtypes of small cell lung cancer.
e20113 Background: Small cell lung cancer (SCLC) is a highly lethal malignancy, and there is an urgent need for more effective therapies. Antibody-drug co...
Clinical-pathological differences in colorectal cancer: Rectum, left colon, and microsatellite instability—ABDON study.
e15653 Background: Colorectal cancer (CRC) is a heterogeneous disease and shows distinct clinical-pathological features based on tumor location and molecu...
Prognostic factors and survival outcome of brain metastases in breast cancer patients: A retrospective analysis.
e14005 Background: Brain metastasis (BM) is an increasingly complicated issue in breast cancer (BC) patients, occurring in approximately 10% to 30% of cas...