Journal of Clinical Oncology
Articles in this Issue
Characterizing cutaneous toxicity from doxorubicin.
e19084 Background: While pegylated liposomal doxorubicin (PLD) is associated with reduced cardiac toxicity and improved efficacy in cutaneous malignancies...
Incidence and outcome of pulmonary hypertension in myelofibrosis.
e24001 Background: Myelofibrosis (MF) is a myeloproliferative neoplasm associated with an increased risk of cardiovascular...
Ultrasensitive ctDNA monitoring during CDK4/6 inhibitor therapy for metastatic breast cancer.
1073 Background: The combination of CDK4/6 inhibitor (CDK4/6i) and endocrine therapy (ET) is the standard first-line treatment for patients with hormone r...
Docetaxel with androgen deprivation therapy (ADT) and radiotherapy (RT) for high-risk localized prostate cancer (HRLPC): An ICECaP individual patient-data (IPD) meta-analysis of randomized controlled trials (RCTs).
5013 Background: There is no established role for the use of docetaxel with ADT and RT for HRLPC, with mixed results seen in prior RCTs. Prior work from I...
Association of neurocognitive impairment and financial hardship in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS).
10055 Background: Adult survivors of childhood cancer are at high risk for financial hardship due to the cumulative lifetime costs of cancer-directed ther...
Landscape of homologous recombination repair pathway germline NGS gene variants in a TNBC-rich cohort of Indian breast carcinoma patients.
e22601 Background: According to the recent 2022-2024 published data from the GLOBOCAN, India alone contributed 15.5% of these cases with a staggering 26%...
Exploring the fibronectin/p21 (CDKN1A) functional axis in breast cancer as a marker of an aggressive disease subgroup.
e12557 Background: Breast cancer is a highly heterogeneous disease concerning both cancer cells and the tumor microenvironment (TME). Fibronectin (...
Racial, geographical, and socioeconomic disparities in patients with rare tumors: SEER database analysis.
e23076 Background: Socioeconomic disparities are recognized as significant contributors to variations in healthcare outcomes, influencing access to treatm...
Final results of afatinib plus chemotherapy with genomic profiling in osimertinib-refractory EGFR-mutant NSCLC: NEJ025B.
8596 Background: Osimertinib is commonly used as a first-line treatment for EGFR-mutated advanced NSCLC. However, the optimal treatment following osimerti...
Transcriptomic analysis of HER2 expression in metastatic breast cancer: Insights from a UAE patient cohort.
1024 Background: HER2-low metastatic breast cancer (mBC) has emerged as a clinically significant subgroup since approval of trastuzumab deruxtecan. Howeve...
Daratumumab + bortezomib, lenalidomide, and dexamethasone (DVRd) vs VRd in transplant-ineligible (TIE)/transplant-deferred (TD) newly diagnosed multiple myeloma (NDMM): Phase 3 CEPHEUS trial cytogenetic subgroup analysis.
7529 Background: In CEPHEUS, DVRd significantly improved overall MRD negativity (MRD neg + ≥CR) and sustained MRD neg rates and PFS in patients (pts) with...
Relationship between access to shelter arrangement and adherence to breast, cervical, and colorectal cancer screening in the Providence's unhoused population.
e13771 Background: Unhoused individuals have higher cancer death rates and reduced cancer screening. In Rhode Island, the number of unhoused individuals i...
Health-related quality of life and financial toxicity among patients with gynecological cancers in southern Nigeria: A multicenter cross-sectional study.
11102 Background: Gynecological cancer-related morbidity and the financial burden of care impact the quality of life of patients. However, the health-rela...
Insights into HPV mediated oropharyngeal squamous cell carcinoma: A northern Nevada epidemiological study.
e22565 Background: Human papillomavirus (HPV) is a known risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with up to 90% of OPSCC cases bein...
Comprehensive analysis of NSAIDs use and oncological outcomes in non-small cell lung cancer patients treated with immune checkpoint inhibitors.
2530 Background: The effect of non-steroidal anti-inflammatory drugs (NSAIDs) on immune checkpoint inhibitors (ICIs) efficacy in non-small cell lung cance...
Phase 1 study of SHR-1826, a c-MET–directed antibody-drug-conjugate (ADC), in advanced solid tumors.
106 Background: MET alterations are key drivers of diverse oncogenic processes, including tumor invasion, growth, and metastasis, and are associated with...
A high-performance blood-based DNA methylation test for early detection of gastrointestinal cancers.
3050 Background: Early detection of gastrointestinal cancers (GICs), including esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC), r...
Safety and efficacy analysis of DNV3 plus toripalimab and chemotherapy in advanced melanoma: An open-label investigator-initiated trial.
9529 Background: Previous studies have shown that combining LAG-3 and PD-1 inhibitors is effective in advanced melanoma. Here, we presented the safety and...
Analysis of the implementation model of the organized screening strategy using the pCR DNA molecular test as the primary test for detecting high-risk human papillomavirus (HPV) for the control and elimination of cervical cancer: Pilot project for nationalization in Brazil.
e13536 Background: Cervical cancer (CC) is a disease with high incidence and disproportionate mortality in low-income and socially vulnerable regions. In...
Phase IIa study of αDC1 vaccines targeting HER2/HER3 combined with pembrolizumab in patients with asymptomatic brain metastasis from breast cancer.
TPS2088 Background: Brain metastases develop in up to 50% of patients (pts) with metastatic breast cancer. Overexpression of HER3 in brain metastatic brea...
Vault proteins as prognostic biomarkers and therapeutic targets in lower-grade gliomas.
2082 Background: Vault proteins, including MVP, VPARP, and TEP1, are components of the vault complex, and are involved in drug resistance, DNA repair, and...
Pan-tumor application of trastuzumab deruxtecan (T-DXd) monotherapy in HER2 3+ advanced solid tumors: A pilot study challenging existing treatment restrictions.
e15012 Background: T-DXd, a novel HER2-targeting antibody–drug conjugate, has demonstrated potent antitumor activity in HER2+ malignancies. Although FDA h...
A predictive model for survival outcome of patients with early-stage medullary breast carcinoma: A population-based study.
e13178 Background: Medullary breast carcinoma (MedBC) is a rare subtype of breast cancer, with a great number of MedBC patients diagnosed with triple-nega...
PSA as a predictor of small cell transformation in prostatic adenocarcinoma: A SEER 2000-2021 study.
e17006 Background: Prostate cancer is the most commonly diagnosed cancer in men, affecting 1 in 8 men in the United States in their lifetime. Adenocarcino...
Risk factors for immune checkpoint inhibitor–related adverse events in the geriatric lung cancer population.
e20579 Background: Immune checkpoint inhibitors (ICIs) have revolutionized the management of lung cancer, especially for the elderly, who may prefer avoid...