Journal of Clinical Oncology
Articles in this Issue
Assessment of urothelial cancer screening outcomes among patients with Lynch syndrome at rural multidisciplinary clinic.
e22618 Background: The National Comprehensive Cancer Network (NCCN) indicates an increased risk for urinary tract and bladder malignancies in Lynch Syndro...
Membrane-specific HER2 expression by artificial intelligence-based quantitative scoring for prediction of efficacy of trastuzumab deruxtecan in biliary tract cancer (HERB trial): Exploratory analysis of a multicenter, single arm, phase II trial.
4097 Background: Trastuzumab deruxtecan (T-DXd) showed promising results in patients with HER2-positive biliary tract canc...
The intricacies of illiteracy, an indigenous language, and religious beliefs on oncology and palliative care: Perspectives from Paraguayan healthcare providers.
e24067 Background: Paraguay is a country with two official languages, Spanish and Guarani. 34.7% of the population speaks both, while 33.4% of the populat...
Patritumab deruxtecan (HER3-DXd) in active brain metastases (BM) from metastatic breast (mBC) and non–small cell lung cancers (aNSCLC), and leptomeningeal disease (LMD) from advanced solid tumors: Results from the TUXEDO-3 phase II trial.
2005 Background: BM and LMD are common and severe complications of solid cancers with high morbidity, poor prognosis, and limited treatment options. Antib...
Evidence of a role for oropharyngeal cancer cells with low HPV gene expression in treatment failure.
6058 Background: A subset of tumor cells with reduced HPV gene expression, here termed HPV-lo cells, are proposed contribute to t...
Real-world effectiveness of first-line chemo-immunotherapy and chemotherapy on ES-SCLC: A propensity score-matched study.
e20110 Background: This study aims to evaluate whether the combination of chemotherapy and immunotherapy offers superior efficacy and prognosis compared t...
Comparative efficacy and safety of immunotherapy for patients with advanced or metastatic esophageal squamous cell carcinoma: A network meta-analysis.
e16079 Background: Integrating immune checkpoint inhibitors (ICIs) with conventional chemotherapy has significantly transformed oncology, creating new tre...
Secondary outcomes by prior definitive treatment (tx) in patients (pts) with high-risk biochemically recurrent prostate cancer (hrBCR) treated with enzalutamide (enza) monotherapy (mono): EMBARK post hoc analysis.
5103 Background: The phase 3 EMBARK trial demonstrated clinically meaningful improvement in metastasis-free survival and secondary efficacy endpoints with...
Trend analysis of risk factors for early-onset primary colorectal cancer: A population-based time trend analysis using the SEER database.
e15717 Background: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths. The incidence...
Socioeconomic disparities in cardio-oncology breast cancer patients from a single institution.
e24018 Background: Breast cancer is associated with significant cardiotoxicity, and underserved populations experience disproportionately higher rates of...
Improving adherence to CDK4/6 inhibitors in breast cancer through remote therapeutic monitoring with real-time adherence tracking and actionable alerts.
e12520 Background: Oral CDK 4/6 inhibitors (CDK4/6is) have transformed the management of HR+/HER2- breast cancer (BC), offering patients (pts) greater fle...
Mortality trends due to endometrial cancer in the United States: A retrospective analysis from 1999-2020.
e17628 Background: Endometrial cancer (EC) is the most common gynecological cancer in the United States (US). The lifetime risk of being diagnosed with EC...
Impact of cancer related fatigue on quality of life of 1,262 patients with breast cancer receiving chemotherapy: A URCC NCORP nationwide phase III RCT.
12130 Background: Cancer-related fatigue (CRF) is one of the most common and debilitating symptoms reported by cancer patients, significantly impairing qu...
Lung cancer mortality in Brazil from 2004 to 2023.
e22578 Background: Lung cancer is one of the leading causes of death by cancer worldwide. An important risk factor is tobacco smoking. However, cases amon...
Effect of genetically engineered <i>Salmonella typhimurium</i> secreting conantokin G on PD-L1 antibody therapy and tumor regression in colorectal cancer.
e14566 Background: Engineered attenuated Salmonella represents an intensive strategy for targeting tumors, which enhances the effe...
CD-19 CAR-T cell therapy in adult B-cell ALL patients: A systematic review of clinical trials.
e19012 Background: Chimeric antigen receptor T cell (CAR-T) therapy targeting CD19 has emerged as a transformative modalit...
Prognostic significance of complete blood cell count-derived inflammatory biomarkers in patients with small cell carcinoma of the cervix.
e17521 Background: Inflammatory markers derived from complete blood cell count have previously been considered prognostic indicators for various diseases,...
CemiplimAb-rwlc survivorship and epidemiology (CASE): Interim results from a prospective study of the safety and effectiveness of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC) in a real-world setting.
9533 Background: Cemiplimab is the first PD-L1 inhibitor approved for the treatment of patients with locally advanced (la) or metastatic (m) cutaneous squ...
Outcomes of elderly patients with early-stage triple-negative breast cancer treated with the KEYNOTE-522 regimen.
609 Background: The KEYNOTE-522 regimen (neoadjuvant pembrolizumab combined with a four-drug chemotherapy backbone, followed by adjuvant pembrolizumab) is...
Protective effects of gallic acid against cadmium-induced neuroinflammation in glioblastoma cells.
e14018 Background: Environmental exposure to cadmium (Cd), a toxic heavy metal, was associated with an increased incidence risk of glioblastoma multiforme...
Analysis of genetic mutation profile and CNS pharmacokinetics in relapsed/refractory primary CNS lymphoma patients responding to novel emavusertib (IRAK4i) and BTKi combination.
2085 Background: Primary Central Nervous System Lymphoma (PCNSL) is a rare and aggressive non-Hodgkin lymphoma with no approved treatments for relapsed/re...
Clinical significance of the CGRP pathway gene expression in advanced solid tumors: A sub-analysis of MONSTAR-SCREEN-2.
2629 Background: Calcitonin gene-related peptide (CGRP), a neuropeptide associated with pain perception, has emerged as a therapeutic target for migraine....
Drivers of homologous recombination deficiency (HRD) in metastatic colorectal cancer (mCRC).
3577 Background: HRD is linked to sensitivity to platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors across various tumor types. Howev...
Use of large language models to extract cancer diagnosis, histology, grade, and staging from unstructured electronic health records.
11176 Background: The oncology ecosystem contains millions of unstructured documents within Electronic Health Record (EHR) systems, including clinical not...
Trends and outcomes in Merkel cell carcinoma: A nationwide analysis of sociodemographic characteristics, inpatient utilization, and mortality (2016–2021).
e21592 Background: Merkel cell carcinoma(MCC) is an aggressive, rapidly progressing neuroendocrine malignancy of the skin. We aimed to analyse the burden...