Journal of Clinical Oncology
Articles in this Issue
DISCO App: A patient intervention to reduce the financial burden of cancer in a diverse patient population.
TPS1659 Background: Financial toxicity, the material and psychological burden of treatment cost, affects up to half of people with cancer and can affect a...
Efficacy and safety of nivolumab and docetaxel combination therapy versus nivolumab monotherapy for the treatment of advanced non-small cell lung cancer: A systematic review and meta-analysis.
e20619 Background: Nivolumab has demonstrated efficacy over chemotherapy for the management of advanced non-small cell lung cancer (NSLC). Recent evidence...
Improving care of older adults with cancer: A randomized trial.
11002 Background: Undertreated symptoms are common among older adults with cancer. Previously, a lay health worker (LHW)-led proactive symptom assessment...
Over a decade of insights into genomic profiling in metastatic colorectal cancer from a phase I setting.
e15588 Background: Despite recent advancements in the treatment of metastatic colorectal cancer (mCRC), including the introduction of new targeted therapi...
Barriers to timely mental health care in cancer patients: A national analysis.
e24060 Background: Patients diagnosed with cancer often face significant mental health challenges, yet many do not receive necessary care due to financial...
Impact of germline <i>BRCA</i> status on clinical outcomes of patients with HR+/HER2- early breast cancer.
559 Background: Germline pathogenic variants (PVs) in the BRCA1 and BRCA2 (g BRCA1/2...
Concurrent GLP1R-agonist use with chemoimmunotherapy for early-stage triple-negative breast cancer.
1115 Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a key class of drugs for treating type 2 diabetes mellitus (DM2) and...
Genomic landscape of 5’methylthioadenosine phosphorylase ( <i>MTAP)</i> deleted ( <i>MTAP</i> loss) non-squamous carcinoma of unknown primary site (nsCUP).
3081 Background: MTAP , a key enzyme in the polyamine pathway breaks down 5’Deoxy-5-Methylthioadenosine ( MTA ) into m...
Circulating tumor HPV-DNA dynamics and neoadjuvant chemotherapy with or without nivolumab in viral-mediated oropharyngeal cancer.
6091 Background: Human papillomavirus-associated (HPV+) oropharyngeal carcinoma (OPC) is linked to favorable survival outcomes, prompting efforts to de-in...
Adjuvant WIDER: A phase 3b trial of ribociclib (RIB) + endocrine therapy (ET) as adjuvant treatment (tx) in a close-to-clinical-practice patient (pt) population with HR+/HER2− early breast cancer (EBC).
TPS617 Background: The phase 3 NATALEE trial met its primary endpoint with significant invasive disease–free survival benefit with RIB + ET vs ET alone in...
A clinical review of a novel blood test use in rural Alabama for multi-cancer detection, analyzing methylation patterns of cell-free DNA and future strategies.
e15183 Background: In 2022 608,366 people worldwide died of cancer and the number is only growing. Galleri is a clinically validated multi-cancer early de...
Characterizing transportation need and missed visits among patients receiving radiotherapy.
1527 Background: Patients with cancer receiving radiotherapy (RT) are vulnerable to treatment interruptions, which affect...
Assessment of fluoropyrimidine and platinum-based chemotherapy regimens in combination with immunotherapy for the treatment of advanced gastric or gastroesophageal junction cancer among patients in the KEYNOTE-062, KEYNOTE-859, RATIONALE-305 and KEYNOTE-811 clinical trials.
e16071 Background: Although chemotherapy combined with immunotherapy has become the first-line standard treatment for advanced gastric or gastroesophageal...
Dynamic circulating tumor DNA-driven, risk-adapted systematic therapy in nasopharyngeal carcinoma: The EP-STAR trial.
6010 Background: Circulating tumor-derived Epstein-Barr virus (EBV) DNA (ctDNA) during treatment has been established as a biomarker in nasopharyngeal car...
Inpatient characteristics and outcomes among adolescent and young adult patients with metastatic breast cancer.
e23083 Background: Breast cancer is the most common cancer among adolescent and young adult (AYA) women in the US, accounting for 15% of all invasive canc...
Impact of health-related social needs (HRSNs) screening and targeted intervention through patient navigation on cancer care outcomes in rural south east Georgia.
e13770 Background: Understanding individual HRSNs is essential to overcome barriers to treatment, deliver high quality care and achieve equity in cancer m...
Cardiovascular disease and gastrointestinal cancers: Mortality trends and persistent disparities in the U.S.
e15684 Background: Cardiovascular disease (CVD) is a significant contributor to mortality among patients with gastrointestinal tract (GIT) cancers. This s...
Spatial transcriptional dynamics of CD74⁺ B cells in tertiary lymphoid structures and effects on immune evolution in penile squamous cell carcinoma.
5038 Background: Antitumor immunity has become a critical focus in improving Penile squamous cell carcinoma (PSCC) patient outcomes. Among various immune...
Effects of lymphatic ablation approaches on immunotherapy efficacy in esophageal squamous cell carcinoma.
e16046 Background: In the era of chemotherapy, extended radical lymphadenectomy was demonstrated to be associated with improved survival of esophageal squ...
Utilization and timing of first tumor next-generation sequencing testing (NGS) in patients (pts) with five most common cancers in the USA.
11014 Background: In the USA, the 5 most common advanced/metastatic solid tumors are advanced non-small cell lung cancer (aNSCLC), metastatic breast cance...
Combined treatment of durvalumab, bevacizumab and tremelimumab in subjects with hepatocellular carcinoma (HCC) or biliary tract carcinoma (BTC).
4081 Background: Anti-VEGF in combination with anti-PD1/PD-L1 represents a synergistic therapeutic strategy that has demonstrated efficacy, prolonging sur...
Monitoring PD-L1 expression in cancer-associated macrophage-like cells as predictor of clinical outcomes in metastatic cancer patients treated with PD-L1 immunotherapies.
2555 Background: Studies have described the efficacy of immunotherapies (IMT) utilizing programmed death 1 receptor and its ligand (PD-L1) for treating so...
Effects of UCHL1 on tolerogenic DC maturation and promotion of mregDC-Treg crosstalk to nullify anti–PD-L1 therapy.
2605 Background: Immune-checkpoint blockade (ICB) therapies have revolutionized cancer treatment, but such immunotherapy regimens fail in a subset of pati...
Nationwide trends and disparities in end-of-life care for acute myeloid leukemia: A 2019–2021 NIS analysis of palliative care utilization and hospitalization costs.
12064 Background: Acute myeloid leukemia (AML) is a life-threatening hematologic malignancy with high morbidity and mortality, particularly among older ad...
Trends in Medicare reimbursement for urological cancer surgeries in male genitourinary malignancies: A 10-year analysis.
e23129 Background: Male genitourinary (GU) cancers, including testicular, penile, kidney, and prostate cancers, necessitate surgical interventions critica...