Journal of Clinical Oncology
Articles in this Issue
A two-decade analysis of gastric cancer mortality in the U.S.
e16038 Background: Gastric cancer (GC) is the fifth most common cancer globally and remains a significant public health burden, with approximately one mil...
Impact of stereotactic ablative radiotherapy (SABR) on detection of ctDNA in patients with early-stage lung cancer: Interim findings from the prospective SABR-DETECT trial.
3044 Background: Stereotactic ablative radiotherapy (SABR) is the preferred curative treatment for inoperable patients with stage I/IIA non–small-cell lun...
Exploring decisional needs of patients considering first line treatment of advanced EGFR+ lung cancer: An interpretive descriptive study.
8612 Background: With expanding treatment options for EGFR+ metastatic non-small cell lung cancer (mNSCLC), shared decision-making is important in alignin...
Study on optimizing serum-based lung cancer diagnosis using a multi-biomarker approach.
8032 Background: Lung cancer remains the leading cause of cancer-related mortality, largely due to the challenges in early diagnosis. Elevated levels of s...
The evolution of breast cancer genetic testing: Comparative outcomes of NCCN, ASCO, and universal guidelines in 6,000+ patients.
10619 Background: Germline genetic testing for breast cancer has significantly advanced over the past decade. At King Hussein Cancer Center, 6,336 breast...
Immune-related endocrinopathy in cancer patients receiving immune checkpoint inhibitor therapy in the nationwide prospective DIRECT cohort.
12132 Background: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, extending patient survival. However, side effects such as endocri...
Machine learning models to predict skeletal-related events in bone metastasis from advanced cancer.
12074 Background: Skeletal-related events (SREs) are detrimental clinical events in bone metastasis from advanced cancer, defined by pathologic fracture,...
Evaluation of large language model (LLM)-based clinical abstraction of electronic health records (EHRs) for non-small cell lung cancer (NSCLC) patients.
11160 Background: Abstraction is a critical step for converting clinical data from unstructured EHRs into a structured format suitable for real-world data...
Machine learning–based sequential analysis for optimal selection between IRD and KRD regimen in multiple myeloma patients.
7525 Background: Multiple myeloma (MM) is hematologic malignancy where personalized treatment strategies are essential to improve outcomes. Proteasome inh...
Exploratory study on the impact of intestinal low-dose radiation on the efficacy and prognosis of immunotherapy in metastatic non-small cell lung cancer.
8571 Background: Radiotherapy (RT) can be a palliative measure for metastases of metastatic non-small cell lung cancer (mNSCLC). However, RT to abdominope...
Anlotinib combined with sintilimab as first-line treatment in patients with advanced non-clear cell renal cell carcinoma (nccRR): Preliminary results from an exploratory prospective multicentre clinical study.
4526 Background: Non-clear cell renal cell carcinoma (nccRCC) accounts for approximately 25% of all kidney cancers, however, the effect of systemic chemot...
National trends in mortality of gastric cancer among older adults (70+) from 1990 to 2021 across 204 nations: A global burden of disease study.
e16074 Background: Gastric cancer is a malignant disease characterized by the uncontrolled growth of cells in the stomach lining. It is a global health co...
Early examination of national changes in potentially avoidable hospital visits after chemotherapy, 2018–2022.
11096 Background: Medicare tallies potentially avoidable hospital visits after chemotherapy and has been publicly reporting this quality measure since 201...
Systemic therapy for advanced epithelioid sarcoma: A meta-analysis of effectiveness and safety study.
e23558 Background: Epithelioid sarcoma (ES) is a rare and aggressive type of soft tissue sarcoma (STS) with limited evidence available on systemic therapi...
Real world efficacy and safety of ivosidenib in US veterans with IDH1 mutated cholangiocarcinoma.
4086 Background: IDH1 mutations occur in 13% of patients with intrahepatic cholangiocarcinoma. Ivosidenib is FDA approved for the treatment of advanced, p...
Clinical outcomes in patients with neuroendocrine tumors and concomitant protein energy malnutrition.
e24057 Background: Neuroendocrine tumors are slow-growing tumors commonly found in the gastrointestinal tract. Diagnosis is often delayed as patients pres...
Radiotherapy plus nimotuzumab versus cisplatin in low-risk locoregionally advanced nasopharyngeal carcinoma who had favorable response to induction chemotherapy: A randomised, phase III, non-inferiority trial.
6078 Background: Patients with low-risk locoregionally advanced nasopharyngeal carcinoma (LA-NPC) have high survival when treated with radiotherapy (RT) p...
Mortality trends in patients with multiple myeloma and renal failure in the United States (1999–2020): A CDC WONDER database analysis.
e19571 Background: Renal failure (RF) leads to significant treatment challenges, morbidity, and cancer-related mortality in patients with multiple myeloma...
Therapeutic impact of BET inhibition on immune cell death checkpoints in MPN.
e18595 Background: Myeloproliferative neoplasms (MPNs) are haematological cancers characterized by excessive bone marrow cell growth and have the potentia...
Nimotuzumab combined with chemotherapy in the first-line treatment for patients with stage IVB, recurrent or persistent cervical squamous cell carcinoma: A multi-center, randomized, double-blind, and controlled study.
5510 Background: Stage IVb, recurrent or persistent cervical cancer patients have limited treatment options and poor survival prognosis. Additionally, 70-...
Molecular profiling using NGS in lung cancer patients: Revolutionizing targeted therapy and personalized treatment.
e20654 Background: Non-small-cell lung cancer (NSCLC) is the most common histological subtype of lung cancer and the leading cause of cancer-related death...
Diagnostic efficacy of <sup>68</sup> Ga-PSMA-PET/CT scan as a single staging modality in prostate cancer: Evidence from a tertiary healthcare centre.
e17130 Background: To explore whether the new 68 Ga-PSMA-PET/CT (Gallium-68 prostate-specific membrane antigen positron emission t...
A phase 2 clinical trial of preoperative pembrolizumab and chemotherapy followed by adjuvant pembrolizumab in resectable locoregionally recurrent head and neck squamous cell carcinoma.
TPS6121 Background: Locoregional recurrence is a major cause of death in squamous cell carcinoma of head & neck (HNSCC) initially treated with curativ...
Association of lymphoma and COVID-19 among hospitalized cancer patients: A population-based cohort study.
e19090 Background: Recent data has suggested there might be a link between COVID-19 and Lymphoma more complex than only an immunocompromised state....
Association of immune-related adverse events with survival and treatment outcomes in thymic tumors treated with immune checkpoint inhibitors.
8111 Background: Thymic tumors are rare cancers with limited therapeutic options, particularly in refractory cases. Immune checkpoint inhibitors (ICIs) su...