Journal of Clinical Oncology
Articles in this Issue
First-in-human study of RAG-01: A novel small activating RNA therapeutic in BCG failure non-muscle invasive bladder cancer (NMIBC) patients.
e16587 Background: Targeting the p21 WAF1/CIP1 (p21) gene represents a promising yet challenging therapeutic strategy in cancer tr...
MHC class I expression and outcomes in breast cancer in the real-world clinico-genomic data and the FinXX trial.
570 Background: Major histocompatibility complex class I (MHC I) plays a critical role in immune surveillance by binding peptides derived from intracellul...
Mortality from ovarian cancer in women of the United States: A 21-year analysis of trends and disparities.
e17551 Background: In the United States, Ovarian cancer ranks 2nd most common gynecological cancer and causes the highest mortality among all the cancers...
NeoCircle: Investigating circulating tumor DNA dynamics as a predictor of survival in primary breast cancer.
3057 Background: Persistent circulating tumor DNA (ctDNA) detection during neoadjuvant treatment (NAT) of early-breast cancer (EBC) indicates high-risk di...
Clinical features associated with an exceptional response to immunotherapy in patients with metastatic non-small cell lung cancer (NSCLC).
8544 Background: Immunotherapy with PD1 axis inhibitors is approved for metastatic non-small cell lung cancer (NSCLC). Outside of tumor PD-L1 expression,...
Mortality rate disparities in breast cancer with obesity: Insights from CDC WONDER analysis of two decades.
e13030 Background: Obesity is a significant risk factor for breast cancer, influencing its incidence and progression, and contributing to mortality. Analy...
Evaluating the utility of DNA methylation signatures in tissue and biofluids for lung adenocarcinoma brain metastasis prediction and non-invasive detection.
2030 Background: Brain metastases (BM) are common and arise in 30% of lung adenocarcinoma (LUAD) patients. Patients with LUAD that develop BM have signifi...
STARLITE 2: Phase 2 study of nivolumab plus <sup>177</sup> lutetium-labeled anti–carbonic anhydrase IX (CAIX) monoclonal antibody girentuximab ( <sup>177</sup> Lu-girentuximab) in patients with advanced clear cell renal cell carcinoma (ccRCC).
TPS4612 Background: CAIX is a cell surface glycoprotein expressed in > 95% of ccRCC but rarely in normal tissues. Radiolabeling girentuximab, a CAIX-ta...
Performance evaluation of a multi-cancer early detection assay using NMR-based molecular signatures in a multi-center study.
e15079 Background: Cancer is the second leading cause of death worldwide, accounting for over 10 million deaths annually. Despite the proven impact of ear...
Real-time clinical validation of a blood cell-free, mRNA-based GeneVerify test for screening and early diagnosis of prostate cancer.
3053 Background: Prostate cancer screening methods, including prostate-specific antigen (PSA) testing, radiological imaging, and pathological assessments,...
The association and impact of radiographic, pathological, and spirometric emphysema on patients with resectable lung adenocarcinoma.
e23250 Background: Destruction of alveoli structure and lung function are interrelated, however, their correlation and clinical significance have been not...
Fecal microbiota transplantation (FMT) for opioid-induced constipation (OIC): A prospective, multicenter, single-arm, phase II clinical study.
TPS12140 Background: Opioids are the cornerstone of cancer pain management. Opioid-Induced Constipation (OIC) is the most common adverse effect of opioid...
The accuracy and efficiency of large language models for chart review in cancer genetics.
e22603 Background: Constructing databases is crucial for answering clinical questions but is time-consuming and error-prone. Our institution has maintaine...
Genomic landscape of Indian DLBCL: Ready for prime time.
e23296 Background: While many studies have explored the mutational landscape of DLBCL, the Indian DLBCL remains relatively unexplored. Studies have shown...
Point-of-care social needs screening and resource navigation for patients with cancer undergoing active treatment: A pilot initiative.
e13800 Background: Patients with cancer undergoing active treatment often face social needs including housing, transportation, food, and financial challen...
Low-pass whole methylome sequencing–based liquid biopsy for metastatic colorectal cancer monitoring in the VALENTINO trial.
3552 Background: The amount of ctDNA is a proxy for metastatic colorectal cancer (mCRC) disease burden, with potentials for prognostic stratification and...
Evaluation of indocyanine green (ICG) and handheld fluorescence imager in the management of early-stage gynecological cancer.
TPS5638 Background: Current management in most early-stage cancers is complete lymphadenectomy for staging. Since surgery is the mainstay of treatment tai...
Preoperative treatment for potentially resectable esophageal cancer: Insights from a nationwide real-world study.
e14598 Background: In the ASTRUM-007 trial, serplulimab combined with chemotherapy significantly prolonged overall survival (OS) in patients with advanced...
Equivalence of Ina, an AI-based nutrition platform, to human dietitians for counseling patients with cancer.
12117 Background: Addressing nutritional issues in patients with cancer can reduce symptoms, shorten hospitalizations, enhance treatment adherence, and im...
Subsequent treatments and outcomes in bacillus Calmette-Guerin–unresponsive patients with high-risk non-muscle invasive bladder cancer with carcinoma in situ: A real-world data analysis.
4604 Background: Intravesical (ives) Bacillus Calmette-Guerin (BCG) is the recommended first-line treatment (tx) option for patients (pts) with high-risk...
Real-world prevalence of homologous recombination repair alterations (HRRa) and poly (ADP-ribose) polymerase inhibitor (PARPi) use/outcomes in patients (pts) with metastatic prostate cancer (mPC) by race and ethnicity.
5077 Background: Racial/ethnic (R/E) disparities in prostate cancer incidence and outcomes have long been noted. Increasing evidence points to underlying...
Long-term results of the randomized, phase 3 KEYNOTE-412 trial of pembrolizumab (pembro) or placebo (pbo) plus concurrent chemoradiotherapy (CRT) for unresected, locally advanced head and neck squamous cell carcinoma (LA HNSCC).
6013 Background: In the final efficacy analysis of the randomized, double-blind, phase 3 KEYNOTE-412 trial (NCT03040999),...
Real-world baseline characteristics and diagnostic path of Polish patients with ALK-positive NSCLC eligible for brigatinib treatment: Interim results from the ENTIRETY study.
e20640 Background: In anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (ALK+ NSCLC), early diagnosis, patient characteristics, and ear...
Impact of antiresorptive bone agents in hormone-sensitive metastatic prostate cancer (mHSPC): A meta-analysis.
e17122 Background: The continuous improvement of survival of mHSPC patients (pts) increases their risk of bone loss. The use of bone modifying agents (BMA...
A zero passage ex-vivosingle cell mass response assay to predict tumor response: An observational analysis in gastrointestinal adenocarcinomas.
e16065 Background: Gastrointestinal cancer remains a significant challenge due to limited effectiveness of current therapies. Clinical and molecular tumor...