Journal of Clinical Oncology
Articles in this Issue
Clinical yield and utility of germline multigene panel testing across hereditary cancer syndromes: A systematic review of real-world evidence.
e22664 Background: Germline multigene panel testing (MGPT) is widely used for hereditary cancer risk assessment , but real...
Early mortality and hospitalization following cholangiocarcinoma diagnosis by statin exposure: A TriNetX real-world analysis.
11195 Background: Statins are widely prescribed among patients with cardiometabolic comorbidities and are frequently conti...
Low-dose radiation therapy for peripheral joint osteoarthritis: Early U.S. community experience with pain, function, and medication outcomes.
e24051 Background: Osteoarthritis (OA) causes progressive pain and disability, yet non-surgical options are limited for pa...
Real-world experience with tarlatamab in extensive-stage small cell lung cancer at an academic center in Mississippi.
e20156 Background: Small cell lung cancer (SCLC) has poor outcomes, and patients from underserved rural and minority popul...
Longer-term safety of pimicotinib in tenosynovial giant cell tumor (TGCT): Integrated analysis of phase 1 and phase 3 MANEUVER trial data.
11568 Background: TGCT is a rare, locally-aggressive neoplasm associated with significant morbidity and functional impairm...
Chemotherapy (CT) use by Oncotype DX (O-Dx) recurrence score (RS) in hormone receptor–positive, HER2-negative (HR+/HER2-) invasive lobular carcinoma (ILC): A contemporary National Cancer Database (NCDB) analysis.
531 Background: ILC has a distinct biology and is considered less chemosensitive than invasive ductal carcinoma (IDC). O-D...
Transposable elements and homotypic niches as drivers of immune dynamics and resistance in melanoma epigenetic-based immunotherapy.
9531 Background: Melanoma plasticity facilitates immune evasion and therapy resistance through dynamic cell-state transiti...
Cancer survivorship care plans: Patients, needs, benefits—retrospective analysis.
e13793 Background: Survivorship care plans (SCPs) are designed to address the needs of cancer survivors transitioning from...
Awareness of breast cancer symptoms and risk factors among urban Delhi women.
e24102 Background: Breast cancer is the most frequently diagnosed malignancy among Indian women, and late presentation con...
Expansion of circulating NKG7⁺ cytotoxic CD4⁺ T cells as a predictor of response to PD-1 blockade in recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC): A prospective phase II study with translational analysis.
6043 Background: Nivolumab has demonstrated meaningful survival benefit in patients with refractory R/M HNSCC. Nevertheles...
Prophylactic vedolizumab to facilitate use of immune-checkpoint inhibitors in cancer patients at high risk of immune-mediated colitis.
12134 Background: Inflammatory diarrhea/colitis is a frequent immune-related adverse event (IRAE) associated with immune c...
Association of inpatient mortality and resource utilization with acute complications among colorectal cancer hospitalizations in the United States.
e23220 Background: Hospitalization for colorectal cancer (CRC) is frequently complicated by acute clinical events. Nationa...
Impact of tumor site and diagnostic pathway on stage at diagnosis: A population-based study of 5,638 salivary gland cancer patients (2013–2023).
e18140 Background: Salivary gland cancer (SGC) are rare and heterogeneous malignancies. Delays in diagnosis are common and...
Clinical and genomic characterization of de novo prostate cancer presenting with PSA ≥100 ng/mL.
e17024 Background: In the era of PSA screening for prostate cancer, presentation with PSA ≥100 ng/mL is rare. We sought to...
Baseline phosphoproteomic signatures in peripheral blood and prediction of durable response to CAR T-cell therapy in B-cell malignancies.
7038 Background: Despite the success of Chimeric Antigen Receptor (CAR) T-cell therapy, most patients fail to achieve dura...
Multimodality neoadjuvant downstaging therapy before liver transplantation for colorectal liver metastasis: Real-world data from the Cleveland Clinic.
3594 Background: Liver transplantation (LT) has a clear survival benefit in advanced, unresectable, liver-confined colorec...
Comprehensive profiling of EGFR PACC mutations and their co-mutation landscape in Chinese patients with non–small cell lung cancer: A large-scale NGS study of 2,360 cases.
8650 Background: EGFR PACC (P-loop and αC-helix compressing) mutations represent a group of noncanonical alterations locat...
Allostatic load as a mediator of exposomic risk pathways to early-onset cancer: A cross-cohort validation study.
10500 Background: Early-onset cancer (EoC, defined as any solid tumor diagnosed ≤50 years age) incidence has incre...
Alternative splicing signatures to predict response from hyperthermic intra-peritoneal chemotherapy (HIPEC) treatment in ovarian cancer patients.
e17576 Background: HIPEC is associated with improved survival in epithelial ovarian cancer (EOC) patients, but no predicti...
Integration of a diabetes practitioner in breast cancer care and its impact on glucose management.
e23064 Background: Dysglycemia in breast cancer patients is associated with poor cancer outcomes and increased emergency d...
Safety and reliability of isatuximab subcutaneous on-body injector: Results across the phase 3 IRAKLIA, phase 2 IZALCO and phase 1b TCD15484 trials.
7563 Background: Subcutaneous (SC) drug delivery options have become more widely available in multiple myeloma (MM). SC de...
A novel ultra-low 6-month PSA cutoff for radiographic PFS stratification in high-volume mHSPC.
e17099 Background: In metastatic hormone-sensitive prostate cancer (mHSPC), a 6-month PSA nadir ≤0.2 ng/mL is commonly app...
Comparative serious safety reporting signals for antibody-drug conjugates versus HER2-targeted non-ADC therapies: A FAERS analysis (2020–2025).
e13084 Background: Antibody–drug conjugates (ADCs) have transformed systemic cancer therapy but are associated with distin...
Indirect calorimetry and estimated energy prescription in hospitalized cancer patients.
e23335 Background: Indirect calorimetry is recommended as the reference method for individualized energy prescription in p...
A phase II, multicenter, single-arm clinical trial of response-adapted definitive radiotherapy and cemiplimab-rwlc immunotherapy for locally advanced, unresectable cutaneous squamous cell carcinoma: RAMPART.
9506 Background: Locally advanced (T3-4/N+/M0) and unresectable cutaneous squamous cell carcinoma (LAUCSCC) patients (pts)...