Journal of Clinical Oncology
Articles in this Issue
Performance of a tissue-free, molecular residual disease assay in colorectal, breast, and lung cancers from circulating tumor DNA.
3042 Background: The Latitude test is a methylation-based, tissue-free molecular residual disease (MRD) test. In this stud...
Frailty-comorbidity discordance and non-relapse mortality after allogeneic hematopoietic cell transplantation.
6552 Background: Non-relapse mortality (NRM) is a barrier to successful allogeneic hematopoietic cell transplantation (HCT...
Sociodemographic and clinical characteristics of women < 50 years and impact on adjuvant chemotherapy decisions across OncotypeDX RS or unknown OncotypeDX categories. A National Cancer Database (NCDB) analysis.
e12547 Background: OncotypeDX recurrence score (RS) provides prognostic and predictive information to guide adjuvant treat...
Patient-level clinical response dynamics in advanced melanoma with anzutresgene autoleucel (anzu-cel), a PRAME-directed T-cell receptor (TCR) T-cell therapy.
9508 Background: Pts with advanced melanoma frequently experience progressive disease (PD) with limited long-term survival...
Regional trends in pancreatic cancer incidence, mortality, and disability-adjusted life years in Pakistan, 1990-2023.
e16414 Background: Pancreatic cancer is a highly fatal malignancy with limited therapeutic options due to late-stage diagn...
Clinical presentation, management strategies, and recurrence rates in vulvar intraepithelial neoplasia (VIN) globally: A systematic review.
e17649 Background: Vulvar intraepithelial neoplasia (VIN) is a premalignant condition that lacks FDA-approved therapies or...
Precision or perplexity: Assessment of discordance among different PD-L1 assays in the same specimen in advanced non–small cell lung cancer in a community setting.
e14579 Background: PD-L1 expression guides immunotherapy selection in NSCLC, yet multiple assays are used interchangeably...
SATMM: A systems genetic network analysis–based risk stratification tool validated across the disease trajectory of relapsed/refractory multiple myeloma.
7559 Background: Precision medicine in multiple myeloma (MM) requires risk stratification tools that account for the patie...
Colorectal cancer detection with a multiomic liquid biopsy: Comparing and combining blood- and stool-based tests.
e15641 Background: Colorectal cancer (CRC) remains one of the leading causes of cancer morbidity and mortality worldwide....
Analysis of eligibility and reporting standards for older patients with hormone receptor–positive, HER2-negative metastatic breast cancer (HR+ MBC) in pivotal phase III clinical trials, 2015-2025.
e13087 Background: Despite the high burden of breast cancer among older adults, there remains underrepresentation of older...
Real-world experience with lifleucel, tumor selection, and dead-in therapy from a single-institution series.
9536 Background: Lifileucel is the first approved cellular therapy for persons with metastatic melanoma after upfront trea...
Real-world analysis of epigenomic molecular tumor-type prediction for biliary tract cancer in CUP.
4161 Background: Biliary cancers (BTC) are often diagnosed at advanced stages and can present as metastatic liver tumors,...
Image-only and multimodal AI digital pathology biomarkers to demonstrate risk stratification across standard prostate cancer management strategies.
5023 Background: Reliable risk stratification across standard treatment pathways is essential for the clinical adoption of...
Neighborhood disadvantage and correlation with differences in somatic mutations in a real-world breast cancer cohort.
577 Background: African compared to European genetic ancestry is associated with lower prevalence of clinically actionable...
A phase II combination study of galunisertib and capecitabine in patients with chemotherapy-resistant colorectal cancer with peritoneal metastases.
3571 Background: Transforming growth factor β (TGF-β) plays a dynamic role in cancer biology. It acts as a tumor suppresso...
Development of multiplex digital PCR–based <i>ESR1</i> and <i>PIK3CA</i> mutation assays for therapeutic decision-making in HR+/HER2− breast cancer.
e13008 Background: Mutations in ESR1 and PIK3CA are clinically important molecular alterations associated with treatment r...
TCM-based syndrome stratification and biological profiling of cancer-related fatigue: A cross-sectional study and scale validation.
e24137 Background: Cancer-related fatigue (CRF) is a prevalent symptom with limited interventions. Traditional Chinese Med...
Venous thromboembolism as a trigger for acute cardiac decompensation during cancer hospitalizations: A National Inpatient Sample analysis, 2018–2022.
e23099 Background: Venous thromboembolism (VTE) is a common complication of malignancy, but its role as a trigger for acut...
Efficacy and safety of pralsetinib in <i>RET</i> fusion–positive solid tumors: Data from the TAPISTRY trial.
3144 Background: Pralsetinib is an oral tyrosine kinase inhibitor that selectively and potently targets oncogenic RET fusi...
Traditional Chinese medicine (TCM) for prevention and management of anti-EGFR monoclonal antibody (mAb)–induced cutaneous adverse reactions in patients with metastatic colorectal cancer (mCRC): A retrospective analysis.
e15584 Background: Anti-EGFR mAb have significantly improved clinical outcomes in mCRC by inhibiting the EGFR signaling pa...
Adverse effects associated with immune checkpoint inhibitors in locally advanced nasopharyngeal carcinoma: A meta-analysis of randomized controlled trials.
e18105 Background: Immune checkpoint inhibitors (ICIs) are increasingly incorporated into curative-intent treatment strate...
SARM1 inhibition to prevent chemotherapy-induced peripheral neuropathy: Translational and early clinical evaluation of SIR2501.
12148 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, cumulative, and often irreversible toxici...
Mortality from myocardial infarction in GI malignancy from 1999 to 2020.
e16332 Background: Cancer patients are at higher risk of myocardial infarction. Malignancy creates conditions that increas...
A clinically deployable deep learning model for decision support and specimen triage in colorectal histopathology with international pathologist validation.
e15514 Background: Colorectal cancer is a leading cause of cancer-related mortality globally, with histopathology as the d...
Shifting demographics and cancer incidence projections in the United States.
e22618 Background: Over the last four decades, racial and ethnic diversity in the United States has increased substantiall...