Journal of Clinical Oncology
Articles in this Issue
Age as a determinant of systemic therapy initiation in advanced colorectal cancer: Experience from an urban safety-net hospital.
e13763 Background: Access is often cited as the primary hurdle in safety-net oncology, yet geriatric factors may drive tre...
Validating a single-item screener for low digital health literacy among surgical oncology patients.
1634 Background: Digital health literacy (DHL; the ability to find and understand health information using electronic medi...
Combining HC-7366 with belzutifan in patients with renal cell carcinoma to alter tumor and microenvironment: Pharmacokinetic and pharmacodynamic (PK/PD) analysis of a phase 1b study.
4535 Background: Clear cell renal cell carcinoma (ccRCC), characterized by loss of von Hippel-Lindau (VHL) tumor suppresso...
Timing of statin initiation for primary atherosclerotic cardiovascular disease (ASCVD) prevention following lung cancer screening in Missouri: A retrospective cohort study.
e22537 Background: Individuals undergoing lung cancer screening (LCS) represent a population at elevated risk for Atherosc...
Clinical outcomes from a multi-institution precision oncology tumor board: The PROMOTE study update.
e23355 Background: The role of next generation sequencing to identify unique genetic makeup of a tumor has become monument...
Real-world pharmacovigilance analysis for antibody drug conjugates (ADCs) in treatment of solid tumor malignancies.
e20503 Background: Despite their efficacy in targeted cancer therapy, antibody-drug conjugates (ADCs) come with unique tox...
Association of immunoglobulin replacement with infection and mortality outcomes in multiple myeloma patients receiving bispecific antibodies: A TriNetX analysis.
e19526 Background: Bispecific antibodies have transformed the treatment landscape for relapsed or refractory multiple myel...
Clinical outcomes of immune checkpoint inhibitors in combination with tyrosine kinase inhibitors in metastatic MSS/pMMR colorectal cancer: A systematic review and meta-analysis.
e15593 Background: Immune checkpoint inhibitors (ICIs) have limited efficacy in microsatellite-stable or mismatch repair-p...
WhatsApp-based behavioral intervention and adherence to adjuvant endocrine therapy in early breast cancer: Real-world data from Brazil.
e13706 Background: Adjuvant endocrine therapy significantly reduces recurrence and mortality in patients with early-stage...
Association between gabapentinoid exposure and chemotherapy-associated peripheral neuropathy among adults starting new neurotoxic chemotherapy in a multi-hospital health system.
e24202 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity of taxane, pla...
Effect of type and location of <i>BRCA2</i> deleterious variant on prognosis and survival in metastatic prostate cancer: A longitudinal, international, cohort study from hormone-sensitive to castration-resistant settings.
10503 Background: Emerging evidence suggests that BRCA -altered prostate cancer (P...
Neurocognitive outcomes after proton versus photon radiotherapy in pediatric CNS tumors: Systematic review and meta-analysis.
e22007 Background: Long-term neurocognitive impairment is a major source of disability in survivors of pediatric CNS tumor...
A phase Ib study of osimertinib and tegavivint as first-line therapy in patients with metastatic <i>EGFR</i> -mutated non–small cell lung cancer (NSCLC).
8648 Background: EGFR TKIs improve clinical outcomes for patients with EGFR-mutated NSCLC. However, they are not curative...
DISCO update: Diagnostic performance of <sup>64</sup> Cu-SARTATE compared to <sup>68</sup> Ga-DOTATATE in patients with known or suspected neuroendocrine tumors.
4174 Background: Diagnostic imaging is critical in the management of neuroendocrine tumors (NETs). 64...
Burden of mortality due to brain metastases secondary to lung cancer in the United States: A population-based study.
2021 Background: Brain metastasis is a common and severe complication in lung cancer, contributing significantly to morbid...
A phase 1b/2 study of JK06, a 5T4-targeted antibody-drug conjugate (ADC), in patients with unresectable locally advanced or metastatic cancer.
3038 Background: 5T4, a Type I transmembrane glycoprotein, is over expressed in a broad spectrum of solid tumors. It modul...
Pan-cancer long mononucleotide repeat microsatellite instability testing for detection and immunotherapy selection.
2648 Background: Microsatellite instability (MSI) and mismatch repair deficiency (dMMR) are crucial biomarkers to inform p...
Telehealth and the patient experience in rural America.
e13708 Background: Rural populations face systemic barriers to healthcare, including specialty scarcity, travel burden, an...
Health-related quality of life with low-dose pembrolizumab plus chemotherapy in early triple-negative breast cancer: Findings from the PLANeT trial.
607 Background: The PLANeT trial randomized stage II–III TNBC patients to neoadjuvant chemotherapy with or without low-dos...
Consensus molecular subtypes, mutational features, and circulating tumor DNA dynamics in colorectal cancer: A real-world clinico-genomic analysis.
3652 Background: Consensus molecular subtypes (CMS) define biologically distinct colorectal cancer (CRC) groups with diffe...
Predictors of response and safety profile of axatilimab in chronic GVHD: Pooled analysis of 384 patients.
e18564 Background: Chronic graft-versus-host disease (cGVHD) remains a significant complication following allogeneic hemat...
GGPP as a driver of esophageal squamous cell carcinoma progression via protein prenylation: Therapeutic potential of zoledronic acid repurposing.
e16104 Background: Esophageal cancer is a prevalent malignant tumor of the digestive system, with its development closely...
A phase 1, first-in-human study of OP-3136, a novel oral selective KAT6A/B inhibitor, as monotherapy in advanced solid tumors and in combination with endocrine therapy in ER+, HER2− advanced breast cancer (ABC): Preliminary results.
3088 Background: Histone lysine acetyltransferases (KATs) control oncogenic transcription and are frequently dysregulated...
Intratumoral heterogeneity of <i>MTAP</i> loss by immunohistochemistry in non–small cell lung cancer: Implications for clinical outcomes.
8025 Background: MTAP-cooperative PRMT5 inhibitors are under development for MTAP-loss solid tumors including non-small ce...
Performance of a cfDNA methylation–based MCED test in patients with clinicoradiologic suspicion of cancer.
10543 Background: Radiographic findings concerning for malignancy frequently prompt extensive diagnostic evaluations that...