Journal of Clinical Oncology
Articles in this Issue
Systemic review and meta-analysis: Treatment-related adverse events of neoadjuvant immune checkpoint inhibitors.
e14581 Background: Immune checkpoint inhibitors (ICIs) are increasingly used in cancer treatment, with recent expansion in...
Neoadjuvant androgen receptor pathway inhibition for patients with high-risk localized prostate cancer: 5-year survival update and PSMA PET correlatives of the randomized NeoPRO trial.
5119 Background: Patients with high-risk prostate cancer remain at elevated risk of recurrence after local therapy. Ongoin...
Real-world survival outcomes with pembrolizumab plus chemotherapy in advanced triple-negative breast cancer: Multicenter evidence from Poland, the Czech Republic, and Slovakia.
e13118 Background: In KEYNOTE-355, pembrolizumab plus chemotherapy improved efficacy versus chemotherapy alone in first-li...
Real-world outcomes of biomarker-intended pembrolizumab use in soft tissue sarcomas.
e23574 Background: Pembrolizumab has a tissue-agnostic FDA indication for metastatic or unresectable solid tumors with hig...
Impact of liquid biopsy training on real-world testing practices for advanced NSCLC across Latin America: The OMEGA (LACOG 0424/GBOT) survey.
9029 Background: The therapeutic landscape of non-small cell lung cancer (NSCLC) has evolved with advances in genomic prof...
Comprehensive characterization of HIF-2α and carbonic anhydrase IX expression and the genomic landscape in clear cell and <i>VHL</i> -altered renal cell carcinoma.
4543 Background: Clear cell renal cell carcinoma (ccRCC) is commonly driven by VHL loss, resulting in HIF-2α stabilization...
Development and validation of a National Database–derived nomogram for predicting postoperative survival in colorectal cancer.
3669 Background: Prognosis after curative-intent surgery for colorectal cancer remains heterogeneous and incompletely expl...
Emotional health concerns due to kidney cancer (KC) and unmet needs in patient support: Results from the International Kidney Cancer Coalition (IKCC) Global Patient Survey (GPS).
4532 Background: KC negatively impacts the emotional well-being of patients, and patient support services are a critical c...
First-in-human study of cavitation-enhanced drug delivery (CEeDD) by sonosensitive particles and focused ultrasound applied to colorectal metastases in the liver.
3549 Background: Effective treatment of colorectal liver metastases is limited by poor drug delivery, particularly for mon...
Infection-associated transitions to critical care–level interventions in adult cancer hospitalizations: A National Inpatient Sample analysis.
e23214 Background: Infectious diagnoses and complications during cancer hospitalizations are commonly evaluated using stat...
Feasibility assessment of a global, anonymized, human-in-the-loop AI decision-support platform for oncology second opinions following a live demo at an international symposium.
e13672 Background: There are widespread disparities in access to rapid, expert-level second opinions worldwide. We assesse...
A trial to evaluate CSF ctDNA and safety of plixorafenib alone or with retifanlimab in patients with BRAF-altered glioma.
TPS2100 Background: BRAF V600E mutant gliomas are difficult to treat in the recurrent setting due to adaptive resistance t...
Data-driven precision prognostic stratification in breast cancer leptomeningeal metastasis: The BC-LGPA model and treatment refinement.
1114 Background: Breast cancer leptomeningeal metastasis (BCLM) lacks data-driven prognostic models integrating diagnostic...
Impact of locoregional treatments in oligometastatic squamous cell anal carcinoma.
e15502 Background: Squamous cell anal carcinoma (SCAC) is a rare malignancy with limited therapeutic options in the metast...
Bevacizumab-based triplet versus doublet chemotherapy as first-line treatment for metastatic right-sided colon cancer: Results of the KCSG CO19-18 phase II trial.
e15562 Background: The prognostic significance of primary tumor location in colorectal cancer has recently gained attentio...
Secondary safety analysis of trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1) in DESTINY-Breast05: Clinical and demographic risk factors of interstitial lung disease (ILD) and radiation pneumonitis (RP).
516 Background: In DESTINY-Breast05 (NCT04622319), T-DXd showed superior efficacy vs T-DM1 in patients (pts) with human ep...
The GP78-Spatial Aggressiveness Index (GP78-SAI): A race-independent AI-driven biomarker for precision oncology.
e12566 Background: GP78 (AMFR) protein expression is associated with breast cancer (BC) progression and poor outcomes (PMC...
Effect of (Z)-endoxifen on estrogen receptor signaling inhibition across clinically relevant <i>ESR1</i> mutations.
e15155 Background: Activating mutations in the estrogen receptor alpha gene (ESR1) are a key mechanism of resistance to en...
Adverse effects of immune checkpoint inhibitors in locally advanced head and neck squamous cell carcinoma: A meta-analysis of randomized trials.
e24179 Background: Immune checkpoint inhibitors (ICIs) have improved outcomes in recurrent and metastatic head and neck sq...
Comparative analysis of mortality trends in acute versus chronic myeloid leukemia in the U.S. population with time series projection: A CDC WONDER–based study (1999–2023).
e18501 Background: Myeloid leukemias (ML) pose a significant public health concern globally and in the United Stat...
Golcadomide (GOLCA), a potential, first-in-class, oral CELMoD, + Pola-RCHP in patients (pts) with newly diagnosed aggressive B-cell lymphoma (a-BCL): Safety and 12-month (mo) efficacy results.
7011 Background: Up to 40% of pts with diffuse large B-cell lymphoma (DLBCL) will relapse or have refractory disease follo...
High-volume patient navigator encounters and access to oncology clinical trials.
e23227 Background: Only 7% of US adults with cancer enroll in clinical trials, despite a rising number of clinical trials...
Ranking neoantigens for escape-resilience rather than predicted immunogenicity: Associated changes in vaccine design.
2654 Background: Personalised neoantigen vaccines induce detectable CD8 + T cell r...
Enhancing recruitment of AYAs with Hodgkin lymphoma through community partnerships: Prioritizing diverse populations.
11026 Background: Hodgkin lymphoma (HL) is one of the most common cancers affecting adolescents and young adults (AYAs). A...
Distinct clinical and genomic landscape of bilateral parenchymal non–small cell lung cancer (NSCLC) using the AACR GENIE BPC database.
e20558 Background: NSCLC with bilateral lung involvement is currently staged as IV (M1a). However, patients with lung-only...