Journal of Clinical Oncology
Articles in this Issue
Interventions to improve hope and psychosocial outcomes in patients with advanced solid tumor cancer: A systematic review and meta-analysis.
e24100 Background: Hope is critical for individuals facing cancer, impacting quality of life, emotional well-being, and en...
The impact of human papillomavirus (HPV) vaccination on cervical cancer risk reduction in the US.
e22531 Background: High-risk human papillomavirus (HPV) causes most cervical cancers. Both HPV vaccination and cancer scre...
Comparative analysis of tirzepatide versus metformin and insulin in type 2 diabetes patients across the 13 most common cancers.
10508 Background: Emerging glucose-lowering therapies may influence cancer risk in patients with type 2 diabetes mellitus...
Incremental prognostic value of an AI-derived histology signature beyond the 21-gene recurrence score: A prospective-retrospective validation in TAILORx.
554 Background: The 21-gene recurrence score (RS) is a foundational tool for risk-stratifying HR+/HER2- early breast cance...
Circulating tumor DNA monitoring for early detection of disease recurrence in bone/soft tissue sarcoma.
11540 Background: Circulating tumor DNA (ctDNA) is a powerful, minimally invasive biomarker of treatment response and pati...
Maintenance therapy and treatment holiday in patients with unresectable/locally advanced/metastatic pancreatic cancer who did not progress after at least 2 months of first-line chemotherapy.
e16372 Background: Although the overall prognosis of metastatic pancreatic cancer remains poor, according to SEER database...
Modern Hodgkin lymphoma treatments to reduce second cancer risks: Influence of risk-adapted screening.
7053 Background: Second primary malignancies (SPMs) are the leading cause of long-term treatment-related mortality in Hodg...
Nutritional anemia and risk of critical illness among hospitalized patients with head and neck cancer.
e18131 Background: Patients with head and neck cancer frequently experience nutritional compromise related to tumor locati...
Association between pre-diagnostic upper endoscopy and metastatic gastric cancer at diagnosis among patients from high-risk groups.
e23446 Background: Gastric cancer is frequently diagnosed at advanced stages in the United States. Although select high-ri...
Impact of immunotherapy on sotorasib toxicity in NSCLC: A real-world matched analysis.
e16184 Background: Sotorasib is a standard targeted therapy for KRAS G12C-mutated...
Induction chemoimmunotherapy followed by hypofractionated radiotherapy and consolidation immunotherapy for locally advanced unresectable non–small cell lung cancer: A prospective phase II study.
8037 Background: Concurrent chemoradiotherapy followed by consolidation immunotherapy is the standard treatment for unrese...
Association of acute kidney injury with in-hospital mortality and resource utilization among U.S. solid tumor hospitalizations: A National Inpatient Sample analysis, 2018–2022.
e23163 Background: Acute kidney injury (AKI) is a common and clinically significant complication among patients hospitaliz...
Early indicators of prostate cancer risk in a community-based screening program in Lagos, Nigeria.
e22503 Background: Community-based prostate health screening programs are important for early identification of men at ris...
Evaluation and appraisal of quality indicators for end-of-life cancer care in an African context.
1517 Background: Population-based quality indicators (QIs) for end-of-life (EoL) cancer care are used to monitor and impro...
Intratumoral heterogeneity and genetic testing utilization in glioblastoma patients: A retrospective study at the University of Vermont Medical Center.
e14091 Background: Glioblastoma (GBM) is a primary malignant tumor characterized by intratumoral heterogeneity. Key biomar...
Development of an online bone marrow transplant (BMT) unit medical education platform for internal medicine (IM) residents: A pilot study.
e21000 Background: Studies demonstrate that less than 50% of Internal Medicine (IM) residents feel comfortable car...
Racial disparities in molecular testing among patients with early-onset metastatic pancreatic ductal adenocarcinoma.
e13752 Background: Germline and somatic genetic testing are considered standard of care for patients with pancreatic ducta...
Functional binding of PD-1 ligands: Overcoming PD-L1 staining limitations to predict therapy response.
2581 Background: Immune-checkpoint blockade (ICB) targeting the PD-1/PD-L1 axis has improved outcomes across multiple mali...
Real-world outcomes in gastrointestinal cancer patients with targetable genomic alterations identified on serial liquid biopsy.
4238 Background: Precision oncology in gastrointestinal (GI) cancers relies on identifying targetable genomic alterations...
Do all patients really need hormonal screening before an adrenal biopsy?
e23070 Background: Timely tissue diagnosis is critical in patients with suspected advanced cancer, particularly as many de...
Representation of rural oncology practices in quality certification programs: Insights from QOPI and CoC data.
e23291 Background: Quality certification programs like the ASCO Quality Oncology Practice Initiative (QOPI), focused on ch...
Association of Medicaid expansion with pre-diagnosis coverage continuity and 2-year overall survival in pediatric patients with blood cancer.
11033 Background: Continuous insurance coverage is critical for timely cancer diagnosis and treatment, yet many patients g...
Analysis of delta-like ligand 3 (DLL3) expression levels and characteristics of patients (pts) with advanced extrapulmonary neuroendocrine carcinomas (epNECs) from an ongoing phase I trial.
2642 Background: Specific DLL3 expression on the surface of epNEC tumor cells makes it a promising therapeutic target, but...
Dysregulation of the insulin-like growth factor system in non–small cell lung cancer tissue and histologically normal lung tissue in patients with varying degrees of COVID-19 severity.
e20046 Background: The COVID-19 pandemic has created new challenges in oncology, particularly in relation to lung cancer....
Baseline immune and gut microbial–metabolic profiles associated with hepatic immune-related adverse events in lung cancer.
e20605 Background: Hepatic immune-related adverse events (HRAEs) are clinically significant toxicities of immune checkpoin...