Journal of Clinical Oncology
Articles in this Issue
XALience: A phase 3, open-label, multicenter, randomized study of xaluritamig plus abiraterone vs investigator’s choice in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer.
TPS5144 Background: In the first-in-human (FIH) study, xaluritamig, a T-cell engager directed at six-transmembrane epithel...
Safety and efficacy of relacorilant and nab-paclitaxel in platinum resistant ovarian cancer: A GRADE assessed systematic review and meta-analysis of randomized controlled trials.
e17604 Background: Relacorilant, a first-in-class selective glucocorticoid receptor antagonist, is being used along with N...
Results from OCEAN II: A phase II study of encorafenib + binimetinib combination in Chinese patients with <i> BRAF <sup>V600E</sup> </i> mutated metastatic non-small cell lung cancer.
8640 Background: Lung cancer is the most common cause of cancer and cancer death in China. Patients (pts) with...
Modular CAR T cells: Advancing flexibility, safety, and efficacy in solid cancer therapy.
e14521 Background: Chimeric antigen receptor (CAR) T cell immunotherapy has revolutionized treatment for hematological mal...
Fitbit-derived activity and heart-rate patterns for predicting 12-month hospitalization in an NIH All of Us cancer cohort.
1629 Background: Hospitalizations in oncology are common and diverse, and are often limited in their predictive accuracy w...
AI-driven virtual transcriptome screening to identify repurposable combination partners for JIN-A02 in NSCLC.
e20528 Background: Combination therapy is a key strategy to overcome drug resistance and improve therapeutic efficacy in n...
A phase 1b study of SYS6002 in advanced solid tumors.
4579 Background: SYS6002 is a next-generation Nectin-4-targeting antibody-drug conjugate (ADC) utilizing a novel site-spec...
Treatment holiday for patients with metastatic hormone sensitive prostate cancer: Real-world experience at a single center.
e17105 Background: Continuous androgen deprivation therapy (ADT) is the standard for patients with hormone sensitive prost...
Systematic safety information gaps in AI-generated melanoma therapy information: An exploratory multi-platform evaluation.
e13704 Background: Patients and clinicians increasingly use large language models (LLMs) for pharmaceutical information. P...
FAPI-CUP: A prospective cohort study of patients with cancer of unknown primary (CUP) to evaluate a novel radiotracer, fibroblast activated protein (FAPI), targeting cancer-associated fibroblasts for primary site detection.
3072 Background: Cancer of unknown primary (CUP) represents a heterogeneous group of metastatic tumours for which standard...
Surufatinib for advanced or metastatic chemotherapy-refractory thymic epithelial tumor: A single-arm, single-center, phase II study.
8119 Background: Thymic epithelial tumors (TETs), though relatively rare, represent the most common anterior mediastinal m...
Empowering pathologists as cancer precision medicine leaders: The Florida Society of Pathologists (FSP) Precision Medicine Academy (PMA) initiative.
e21013 Background: As cancer care increasingly relies on molecular and genomic biomarkers, pathologists play a central rol...
Efficacy and safety of vebreltinib in advanced clear cell sarcoma (VEBrant): A multicenter, phase II study.
11503 Background: Clear cell sarcoma (CCS) is an ultra rare cancer with no established standard systemic therapy of proven...
DZD6008, a fourth-generation EGFR TKI, in pretreated NSCLC patients with <i>EGFR</i> C797X mutations: Results from phase 1/2 studies.
8520 Background: Patients with EGFR-mutant NSCLC whose disease progresses on or after 3 rd...
Circulating tumor DNA (ctDNA) dynamics as early biomarkers of response to enfortumab vedotin plus pembrolizumab (EVP) in advanced urothelial carcinoma (aUC).
4582 Background: Radiographic assessment of treatment response remains challenging in aUC. ctDNA testing offers a sensitiv...
Larynx preservation via chemotherapy-free neoadjuvant sintilimab-cetuximab-SBRT and response-adapted treatment in locally advanced laryngeal cancer: A phase II, single-arm clinical trial (the NeoVOICE study).
6095 Background: The current standard of care for locally advanced laryngeal squamous cell carcinoma (LA-LSCC), including...
Patterns of use and adherence to breast cancer clinical practice guidelines among Brazilian medical oncologists: The GUIDE-Breast survey (LACOG 0924-GBECAM|D9673N00006).
e23146 Background: Clinical practice guidelines are central to standardize breast cancer (BC) care and reduce disparities...
Survival, fertility preservation, and pregnancy after treatment in young patients with BRCA-associated triple-negative breast cancer.
e23345 Background: As survival outcomes improve with novel systemic therapies, fertility preservation (FP) and post-treatm...
A phase Ib/III randomized double-blinded placebo-controlled study of suvemcitug combined with trifluridine/tipiracil for refractory metastatic colorectal cancer.
TPS3674 Background: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. For patients with metast...
A real-world study of triple-negative breast cancer patients with brain metastases: A multicenter retrospective analysis.
e13130 Background: Triple-negative breast cancer patients with brain metastasis (TNBC-BM) have extremely poor prognosis, p...
Clinical implications of primary and metastatic tumor-informed clonal tracking for MRD assessment in oligometastatic colorectal cancer.
3601 Background: While minimal residual disease (MRD) assays informed by primary tumor sequencing have demonstrated progno...
Associations between neighborhood disadvantage, cannabis use, and patient-reported outcomes among patients with cancer.
e13501 Background: Cannabis use is proliferating among oncological populations. However, research is limited on whether ca...
Improving hematology/oncology education for physician trainees through an interactive online platform.
e21008 Background: Internal Medicine residency education in Hematology/Oncology remains challenging due to the complexity...
Inpatient mortality across gastrointestinal malignancies by hospital structural characteristics in the United States, 2018–2022.
e16353 Background: Inpatient mortality among gastrointestinal (GI) cancer hospitalizations is often attributed to tumor bi...
The efficacy of adjuvant chemoendocrine versus endocrine therapy alone in hormone receptor-positive, HER2-negative early breast cancer: A meta-analysis of reconstructed individual patient data.
e12504 Background: The benefit of adding adjuvant chemotherapy to endocrine therapy for hormone receptor–positive (HR+), H...