Journal of Clinical Oncology
Articles in this Issue
Development of novel anti-cancer drug by “locking inhibition” of amino acid transporter LAT1.
e15105 Background: Large Amino Acid Transporter 1 (LAT1) is critical for transporting essential amino acids, enabling the...
Association of neutrophil percentage-to-albumin ratio with progression-free survival and overall survival in cancer patients treated with PD-1/PD-L1 inhibitors.
2574 Background: The Neutrophil Percentage-to-Albumin Ratio (NPAR) reflects systemic inflammation and nutritional status....
Trends in mortality from unspecified malignant neoplasm of the liver among U.S. adults aged ≥45 years, 1999–2023.
e16196 Background: Unspecified malignant neoplasm of the liver (ICD-10: C22.9) represents a diagnostic category encompassi...
Cost-effectiveness analysis of aspirin and structured exercise as adjuvant therapy in localized colorectal cancer.
3650 Background: The ALASCCA trial demonstrated that 160 mg of aspirin daily for 3 years reduced the risk of localized col...
RECON: A trainee-led, needs-informed professional development and global connectivity model for young oncologists in low- and middle-income countries.
9039 Background: Oncology trainees and early-career oncologists (ECOs) in low- and middle-income countries (LMIC) face per...
Evaluation of clinical success and adverse events with endoscopic ultrasound-guided biliary drainage (EUS-BD) compared to percutaneous transhepatic biliary drainage (PTBD) after failed ERCP in malignant biliary obstruction: A systematic review and meta-analysis.
4186 Background: ERCP fails to achieve biliary decompression in ~3–10% of malignant biliary obstruction cases. Rescue drai...
Clinical characteristics, treatment patterns, and outcomes for patients with germ-cell tumor and brain metastases at diagnosis vs. relapse.
e17014 Background: Brain metastases (BM) occur in 2-3% of all patients (pts) with GCT. Data is limited for clinical charac...
Retrospective review of the first three years of a pilot colorectal cancer screening program in the Dominican Republic.
e13630 Background: There are no national colorectal cancer (CRC) screening guidelines in the Dominican Republic (DR) and C...
The lineage-defining transcription factors FOXA1 and POU2F3 as markers of poor prognosis across two large cohorts of thymic malignancies.
e20172 Background: Thymic epithelial tumors (TETs) are rare neoplasms arising in the anterior mediastinum. TETs are strati...
Prognostic factors and impact of concomitant medication in extensive-stage small cell lung cancer (ES-SCLC) treated with first-line chemotherapy plus anti-PD-L1: A Spanish multicenter real-world study.
8107 Background: Platinum - etoposide with PD-L1 inhibitors is the standard first-line treatment for ES-SCLC. However, rea...
Temporal trends in breast cancer case volume, subtypes, and age at diagnosis in Vietnam: An eight-year analysis of 15,227 patients.
e23375 Background: Breast cancer subtype distribution and age at diagnosis may differ between Asian and Western population...
Sex-based differences in metastasis among patients with early-onset pancreatic ductal adenocarcinoma.
e16423 Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by early systemic dissemination and a strong p...
A phase 2 study of neoadjuvant nivolumab (nivo) + relatlimab (rela) in high-risk stage II cutaneous melanoma (NeoReNi).
9502 Background: Patients (pts) with stage II melanoma account for ~50% of those who develop metastatic disease. Checkpoin...
Efficacy, safety, and quality of life outcomes of 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: A GRADE-assessed systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials.
5062 Background: 177Lu-PSMA-617 radioligand therapy (RLT) offers a targeted approach for metastatic castration-resistant p...
STK11 and/or KEAP1 alterations in KRAS-mutant NSCLC treated with immune checkpoint inhibitors or chemotherapy: An episode-based Project GENIE analysis.
8544 Background: STK11 and KEAP1 alterations are linked to aggressive biology in KRAS-mutant NSCLC and have been proposed...
Opportunities for lung cancer screening: A prospective cross-sectional study of patients with lung cancer treated at an academic cancer center.
e22528 Background: In 2021, the U.S. Preventive Services Task Force (USPSTF) expanded criteria for lung cancer screening (...
Polypharmacy discussions in older adults with newly diagnosed acute myeloid leukemia (AML).
e13760 Background: Polypharmacy, the use of ≥5 medications, is common in older adults and associated with worse outcomes i...
Phase 3 trial ResQ201A of nogapendekin alfa inbakicept (NAI) plus tislelizumab and docetaxel vs. docetaxel monotherapy for advanced or metastatic NSCLC resistant to ICI therapy.
TPS8671 Background: Immune checkpoint inhibitors (ICIs) are approved as monotherapy and in combination with chemotherapy i...
Serum miR-181-5p, miR-214-3p, and miR-223-3p expression in epithelial ovarian cancer.
e17539 Background: Detection of epithelial ovarian cancer (EOC) remains challenging because of nonspecific symptoms and th...
Venous sinus involvement in meningiomas and its association with intracranial hypertension features.
e14109 Background: Meningiomas involving dural venous sinuses may cause symptoms mimicking idiopathic intracranial hyperte...
Using artificial intelligence (AI) as a decision support tool in clinic.
e13647 Background: Multidisciplinary reviews (MDR) can alter the management of cancer cases. We previously presented more...
Tolerance of gemcitabine–oxaliplatin (GEMOX) in advanced and metastatic gallbladder cancer: A real-world, single-center retrospective study from north India.
e16224 Background: Gallbladder cancer (GBC) is highly prevalent in North India and commonly presents at an advanced or met...
Clinical impact of baseline serotonergic antidepressant use on survival and immune-related adverse events in lung cancer patients treated with immune checkpoint inhibitors: A large multicenter matched cohort study.
e20618 Background: Preclinical and mechanistic studies suggest that serotonergic antidepressants, including selective sero...
Atypical radiologic response patterns in patients treated on immunotherapy clinical trials: A retrospective lesion-level analysis.
e14600 Background: RECIST 1.1 is the standard method for tumor response assessment but may not adequately capture atypical...
A phase 3, randomized, open-label study of INCB123667 versus investigator's choice of chemotherapy in patients with platinum-resistant ovarian cancer with cyclin E1 overexpression (MAESTRA 2, ENGOT-OV95, GOG-3137).
TPS5642 Background: Epithelial ovarian cancer (EOC) accounts for ~90% of ovarian cancers, with high-grade serous ovarian c...