Journal of Clinical Oncology
Articles in this Issue
Construction of a whole-course psychological nursing model and its impact on compliance with innovative drug therapy in patients with thoracic tumors: A prospective randomized controlled study.
e13544 Background: Thoracic tumors remain associated with high morbidity and mortality. With advances in precision medicin...
ADAPT-M: A tool to predict individualized benefit from adjuvant anti–PD-1 (PD-1) in resected high-risk melanoma.
9567 Background: Resected stage IIB/C and microscopic stage IIIA/B/C/D melanoma presents a significant risk of recurrence...
Impact of treatment facility type on survival outcomes in elderly patients with mantle cell lymphoma: A National Cancer Database analysis.
e19067 Background: Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma affecting older adults and associated with po...
Trial growth and accessibility: Enrollment-weighted access to U.S. lung cancer clinical trials (2015–2025).
e23116 Background: Although U.S. lung cancer trials have expanded over the past decade, trial counts alone may overestimat...
T320 tissue factor-targeted ADC from pre-clinical research to phase I clinical study.
e15032 Background: Tissue factor (TF) is highly expressed in various malignant tumors, including pancreatic, cervical, lun...
Patient-reported outcomes (PROs) and health-related quality of life (HRQoL) with taletrectinib in advanced ROS1+ non-small cell lung cancer (NSCLC) from the TRUST-II study.
8629 Background: Taletrectinib is a next-generation, CNS-active, selective ROS1 tyrosine kinase inhibitor (TKI) approved b...
Efficacy and safety of adding S-1 to chemotherapy regimens in advanced gastric cancer: A meta-analysis.
e16074 Background: Gastric cancer (GC) remains a major global health burden, ranking as the fifth most commonly diagnosed...
Tislelizumab plus cetuximab and irinotecan in relapsed/refractory RAS/BRAF wild-type and microsatellite stable metastatic colorectal cancer: A randomized, controlled, multicenter study (TEC2).
3530 Background: Under suboptimal efficacy and safety of current third-line standard-of-care (SoC), several single-arm stu...
T-Bren (BL-M07D1) in patients with recurrent or metastatic (R/M) ovarian cancer: Results from two phase II studies.
3003 Background: T-Bren is a HER2-directed antibody-drug conjugate (ADC) consisting of an anti-HER2 monoclonal antibody li...
Evaluation of treatment outcomes in ductal and intraductal prostate cancer: Insights from the National Cancer Database.
5122 Background: Ductal and intraductal Prostate carcinoma (DPC) are rare and aggressive histological subtypes of prostate...
Predictive value of genomic mutation signatures and tumor mutational burden for induction immunochemotherapy in locally advanced squamous cell carcinoma of the oropharynx, larynx, and hypopharynx.
e14592 Background: The predictive role of programmed death-ligand 1 (PD-L1) expression in patients (pts) with head and nec...
Olanzapine versus aprepitant based triple antiemetic regimens for the prevention of chemotherapy-induced nausea and vomiting in adult patients receiving highly emetogenic chemotherapy: A systematic review and meta-analysis.
e24088 Background: Chemotherapy-induced nausea and vomiting (CINV) significantly affects treatment tolerance and quality o...
First-line treatment patterns of advanced non–small cell lung cancer in patients with and without pre-existing autoimmune diseases.
e20626 Background: Immune checkpoint inhibitors (ICIs) are established first-line therapies for advanced NSCLC (aNSCLC). H...
Economic evaluation of a designated oncology pharmacist in hemato-oncology outpatient care: A randomized clinical trial.
11063 Background: Adverse drug reactions (ADRs) and medication errors are major contributors to morbidity and healthcare u...
Anthracycline- and immunotherapy-free neoadjuvant chemotherapy versus KEYNOTE-522 regimen in early-stage triple-negative breast cancer.
e12647 Background: Neoadjuvant chemotherapy (NACT) is standard of care in early-stage triple-negative breast cancer (TNBC)...
Risk of renal adverse events (RE-AE) and electrolyte changes with immunotherapy (IT) in a real-world cohort.
11149 Background: IT is used across multiple tumor types but is linked to immune-related AE (irAE), including RE-AEs. Acut...
Trends in mortality due to lung cancer and infectious respiratory diseases in US from 1999 to 2020: A CDC WONDER analysis.
e20117 Background: Respiratory illnesses, especially infections and lung cancer, are among the deadliest health issues wor...
Cancer cachexia staging as a predictor of treatment receipt and survival in pancreatic ductal adenocarcinoma.
e16354 Background: Many individuals with pancreatic ductal adenocarcinoma (PDAC) do not receive treatment or enroll in cli...
Prognostic heterogeneity of metastatic patterns in prostate cancer relative to bone-only disease.
e17108 Background: Metastatic prostate cancer exhibits heterogeneous patterns of spread, but prior studies have not distin...
De-escalation in the elderly: Adjuvant fluoropyrimidine monotherapy vs oxaliplatin-based regimens in stage 3 colon cancer patients aged ≥ 75.
e15646 Background: Addition of oxaliplatin to adjuvant fluoropyrimidine therapy (FOLFOX/CAPOX) is the established standard...
Patient-reported outcomes for identification of distinct tolerance phenotypes with differential survival impact under osimertinib in EGFR-mutated NSCLC.
e24178 Background: In advanced EGFR-mutated NSCLC, osimertinib is administered over prolonged periods, making patient-repo...
Efficacy and safety of tislelizumab and apatinib combined with hepatic arterial infusion chemotherapy for advanced intrahepatic cholangiocarcinoma: A single-arm, phase 2 study.
e16169 Background: Advanced intrahepatic cholangiocarcinoma (ICC) remains a highly aggressive malignancy with limited trea...
Conditional survival following first-line treatment of MSS metastatic colorectal cancer: A pooled analysis of 12 randomized controlled trials.
e15565 Background: Metastatic colorectal cancer (mCRC) has a poor prognosis and is a major burden to patients and healthca...
Five-decade national trends and forecasting of brain tumor mortality among older adults in the United States, 1968–2035.
e14051 Background: Malignant brain tumors remain a major contributor to neurologic mortality in older adults. Despite adva...
Baseline prevalence of lung cancer screening and covariates among women undergoing breast cancer screening in Missouri.
e22562 Background: We sought to evaluate lung cancer screening (LCS) uptake and determine factors associated with LCS amon...