Journal of Clinical Oncology
Articles in this Issue
What is the optimal timing of radiotherapy and immunotherapy in lung cancer? A meta-analysis of randomized trials using reconstructed Kaplan–Meier data.
e20076 Background: The increasing use of combined radiotherapy (RT) and immunotherapy (IO) in lung cancer is driven by evi...
ILF2 as a predictor of cisplatin resistance and clinical outcomes in intrahepatic cholangiocarcinoma.
3122 Background: Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive biliary tract cancer with increasing global...
Cigarette smoking on outcomes with osimertinib in <i>EGFR</i> -mutated non–small cell lung cancer: A real-world analysis.
e20680 Background: Osimertinib is a preferred therapy for patients with EGFR-mutated non–small cell lung cancer (NSCLC). H...
Locally advanced or metastatic thyroid cancer treated with donafenib with or without chemotherapy: A real-world study.
e18019 Background: Neoadjuvant therapy is often required for patients (pts) with locally advanced thyroid cancer (LATC). O...
SCIntMatch: A probabilistic soft-matching framework for integrating single-cell genomes and transcriptomes to dissect adaptive resistance in patients with esophageal cancer.
e16012 Background: Adaptive resistance remains a major barrier to effective radiation therapy in esophageal cancer. While...
Early detection of second primary solid tumors in patients with an index solid malignancy.
e13792 Background: Multiple primary malignant neoplasms (MPMN) are defined as two or more independent malignant tumors wit...
Updated design of INVOKE: A phase 1 study of OKN4395, a first-in-class EP2/EP4/DP1 triple prostanoid receptor antagonist, in patients with advanced solid tumors.
TPS2681 Background: The immunosuppressive pathway of prostaglandin E 2 (PGE...
Evaluation of clinicopathological features and prognosis of patients with small cell carcinoma of gastrointestinal system origin.
e16481 Background: Small cell carcinoma of gastrointestinal origin is a rare, highly aggressive neuroendocrine malignancy...
Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.
e18573 Background: The choice of conditioning intensity for patients with acute myeloid leukemia (AML) undergoing allogene...
Expression of FGFR2b and HER2 in gastric cancer: Implications for targeted therapy selection.
e16106 Background: FGFR2b and HER2 are clinically relevant therapeutic targets in gastric cancer (GC), with multiple targe...
Initial results from EXCEED, a phase 1 study of LY4101174, an antibody-drug conjugate targeting Nectin-4, in participants with advanced or metastatic urothelial carcinoma.
4517 Background: Enfortumab vedotin plus pembrolizumab (EVP) is the current first-line standard of care for locally advanc...
Real-world effectiveness and safety of elranatamab in patients with relapsed/refractory multiple myeloma: Preliminary results from the prospective, non-interventional MagnetisMM-16 study.
e19507 Background: Elranatamab is a B-cell maturation antigen–CD3 bispecific antibody approved for the treatment of adult...
Cumulative low-dose ionizing radiation exposure in frequent emergency department encounters and implications of carcinogenic risk.
e23157 Background: Repeated low-dose ionizing radiation (IR) over short intervals can accumulate causing DNA damage and in...
Nutraceutical therapies for radiation-induced injury: A systematic review and meta-analysis.
e24196 Background: Radiation-induced edema and necrosis are common, dose-limiting toxicities. Corticosteroids remain first...
A patient-tailored protein marker blood test for monitoring treatment response and postoperative recurrence across multiple cancers.
e15047 Background: ctDNA-based minimal residual disease (MRD) assays are increasingly used for post-treatment surveillance...
Racial and ethnic differences in breast-conserving surgery after neoadjuvant chemotherapy for HER2-positive and triple-negative breast cancer.
e13724 Background: Neoadjuvant chemotherapy (NACT) increases eligibility for breast-conserving surgery (BCS) among patient...
Siltuximab for the prevention of severe immune-related adverse events during immune checkpoint inhibitor rechallenge in advanced cancer: First interim analysis of the CIRES trial.
e24146 Background: Immune checkpoint inhibitors (ICI) predisposes patients to unpredictable irAEs. Many patients who had i...
Initial findings from the PROMISE Registry, a US decentralized, prospective prostate cancer genetic registry.
10610 Background: The role for genetic testing (GT) for prostate cancer (PCa) patients (pts) has expanded to find pts with...
Molecular testing, first-line treatment patterns, and survival in metastatic non–small cell lung cancer in Colombia: The RECAPC multicenter registry.
e20670 Background: Real-world Latin American NSCLC cohorts that jointly capture molecular testing, insurance coverage, tre...
Patient and caregiver knowledge and understanding of acute myeloid leukemia and satisfaction with oncologist communication.
e24104 Background: Acute myeloid leukemia (AML) is primarily diagnosed in older adults who often need caregiver support. T...
Association of response with survival in patients with relapsed/refractory high-risk neuroblastoma: A report from NANT Consortium.
10033 Background: Patients with relapsed/refractory (RR) high-risk neuroblastoma (HR-NB) have poor survival. Tumor respons...
Comparative analysis of mitochondrial free radical markers in endometrioid adenocarcinoma and an experimental model.
e17627 Background: Endometrial cancer (EC) is the sixth most common cancer worldwide. In postmenopausal women, adipose tis...
CXCL12 <sup>+</sup> pericytes as drivers of lymphatic dissemination in pancreatic cancer: Integrated single-cell and spatial analysis.
4126 Background: Pancreatic ductal adenocarcinoma (PDAC) exhibits poor prognosis largely due to early lymph node metastasi...
Enrichment of the germline <i> NLRC5 <sup>Pro191Leu</sup> </i> variant in patients with immune checkpoint inhibitor–induced hepatitis.
2660 Background: Immune checkpoint inhibitor–induced hepatitis (ICI-hepatitis) is a clinically significant immune-related...
A retrospective analysis of concomitant opioid usage with immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma.
e18103 Background: Cancer-related pain is a significant consequence of disease for recurrent/metastatic head and neck squa...