Journal of Clinical Oncology
Articles in this Issue
Closing the diagnostic gap: A three-step AI safety-net workflow to capture missed lung nodules on chest radiographs in routine clinical practice.
3 Background: Incidentally encountered lung nodules on chest radiographs (CXRs) are frequently overlooked in routine clini...
Second primary malignancy risk in Hodgkin lymphoma survivors in the modern treatment era: A SEER MP-SIR analysis, 2000–2022.
253 Background: Second primary malignancies (SPMs) remain a leading cause of late mortality among Hodgkin lymphoma (HL) su...
Assessing the impact of the COVID-19 pandemic on the diagnosis and staging of pancreatic cancer: A Surveillance, Epidemiology and End Results analysis.
130 Background: The COVID-19 pandemic markedly affected the U.S. health care system and may have altered the diagnosis and...
Engineered <i>Escherichia coli</i> Nissle 1917 carrying D-lactate dehydrogenase to suppress glioblastoma malignancy via gut-brain axis reprogramming.
76 Background: Glioblastoma (GBM) is the most aggressive primary brain tumor with limited therapeutic options and poor pro...
A comparative analysis between clinicopathologic correlates of mismatch repair status compared to combined mismatch repair status and microsatellite instability in Filipino patients with colorectal cancer.
124 Background: Colorectal cancer (CRC) management relies on molecular classification, specifically the Mismatch Repair (M...
Impact of concurrent liquid and tissue NGS in advanced NSCLC: Real-world insights from an Indian single-centre study.
172 Background: Tissue NGS guides treatment in advanced NSCLC but is often limited by inadequate samples and delayed resul...
Role of surgery in locally progressive gastrointestinal stromal tumors after imatinib therapy: A prospective multicenter real-world study.
121 Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal trac...
Contraceptive awareness and practice in breast cancer cases across the cancer care continuum: A mixed method research.
36 Background: Premenopausal breast cancer cases account for almost one-third of prevalent cases. There are no specific re...
Neoadjuvant chemotherapy plus serplulimab and immuno-response molecular subtype for pMMR locally advanced rectal cancer (FIRM).
110 Background: Immune checkpoint blockade (ICB) shows limited efficacy in mismatch repair proficient (pMMR) locally advan...
Prognostic impact of pathological skin and bone invasion in buccal mucosa squamous cell carcinoma.
233 Background: Buccal mucosa squamous cell carcinoma (BMSCC) frequently presents with locally advanced disease and invasi...
PIK3CA alterations in metastatic colorectal cancer.
150 Background: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA...
Environmental metal exposure patterns and health-related quality of life in northeast Indian gallbladder cancer patients: A metallomic clustering study.
144 Background: Northeast India is a global gallbladder cancer (GBC) hotspot, where environmental metal exposure is a susp...
Treatment outcomes and prognostic factors in neuroendocrine carcinoma of the esophagus in Vietnam: A retrospective cohort study.
128 Background: Esophageal neuroendocrine carcinoma (ENEC) is a rare and highly aggressive malignancy for which no standar...
Early best supportive care and quality of life trajectories in breast cancer: A multivariate analysis of treatment response patterns.
29 Background: Early integration of palliative care may modify quality of life (QoL) trajectories in cancer patients, but...
Associations of multiple dietary indices with health outcomes and diet-related greenhouse gas emissions in U.S. adults: Evidence from NHANES 2005–2018.
299 Background: Dietary patterns directly influence both human health and environmental attributes, yet comparative eviden...
Last Departure: A nurse-led innovation to standardize and humanize end-of-life care in oncology.
338 Background: End-of-life (EOL) care is frequently inconsistent across clinical settings, resulting in distress for fami...
Endoscopic submucosal dissection for early gastrointestinal neoplasms: A prospective study of 50 cases in 45 patients in Vietnam.
104 Background: Endoscopic submucosal dissection (ESD) is established as a curative modality for early gastrointestinal ne...
ICTriplex (chemotherapy + immune checkpoint inhibition + targeted therapy) in advanced/refractory malignancies: A personalized treatment program.
82 Background: Advanced and refractory malignancies remain associated with poor outcomes and limited treatment options. Wh...
Targeting tumoral CXCL3 in triple-negative breast cancer: Association with tumor vasculature and immune surveillance.
32 Background: Triple Negative Breast Cancer (TNBC) accounts for 10-20% of breast cancers and is characterized by poor pro...
Comparative real-world outcomes of durvalumab plus gemcitabine/cisplatin versus pembrolizumab plus gemcitabine/cisplatin as first-line therapy for advanced biliary tract cancer.
133 Background: Durvalumab plus gemcitabine/cisplatin (D+GC; TOPAZ-1) and pembrolizumab plus gemcitabine/cisplatin (P+GC;...
Pathological complete response after neoadjuvant chemoimmunotherapy with toripalimab or camrelizumab in esophageal squamous cell carcinoma: A systematic review and meta-analysis.
109 Background: Neoadjuvant chemoimmunotherapy has reshaped the treatment paradigm for esophageal squamous cell carcinoma...
GLP-1 receptor agonist use and colorectal cancer risk in patients with inflammatory bowel disease.
138 Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RA’s) have advanced the treatment of type 2 diabetes mell...
Proteolysis-targeting chimera (PROTAC) to target Bruton tyrosine kinase (BTK) degradation in mantle cell lymphoma.
261 Background: Mantle cell lymphoma (MCL) is characterized by Bruton tyrosine kinase (BTK)-signaling which activates the...
Polatuzumab-R-CHP vs R-CHOP in older DLBCL: Survival benefit, infectious toxicity, and cost implications in middle-income health systems.
246 Background: Polatuzumab vedotin combined with rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) im...
A retro-prospective study to determine the patterns of recurrence in gastric and GE junction cancers after curative intent treatment at a tertiary cancer centre of North India.
122 Background: Gastric cancer remains one of the leading causes of cancer-related mortality worldwide. Despite advancemen...