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Optimization of the PROTAC linker region of the proteasome substrate receptor hRpn13 rationalized by structural modeling with molecular dynamics

Journal of Biological Chemistry Xiuxiu Lu, Venkata R. Sabbasani, Bakar Hassan et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108520

Elevated mevalonolactone from Ruminococcus torques contributes to metabolically unhealthy obesity development

Journal of Biological Chemistry Hong-Yu Nie, Meng-Fei Zhao, Tian-Yu Wu et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110281

Improving outcomes of patients with pancreatic cancer

Nature Reviews Clinical Oncology Stephan B. Dreyer, Philip Beer, Sunil R. Hingorani et al. Jun 01, 2025 DOI: 10.1038/s41571-025-01019-9

SART1 uniquely localizes to spindle poles forming a SART1 cap and promotes spindle pole assembly

Journal of Biological Chemistry Hideki Yokoyama, Daniel Moreno-Andrés, Kaoru Takizawa et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108561

Durable responses to belzutifan in patients with VHL disease

Nature Reviews Clinical Oncology Peter Sidaway Jun 01, 2025 DOI: 10.1038/s41571-025-01023-z

Potent activity of prostaglandin J2 on prostanoid DP receptors

Journal of Biological Chemistry Kanaho Senoo, Keijo Fukushima, Hitomi Yamamoto et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108523

Sacituzumab tirumotecan improves OS in mTNBC

Nature Reviews Clinical Oncology David Killock Jun 01, 2025 DOI: 10.1038/s41571-025-01022-0

UCHL1 regulates adiponectin receptors in Sertoli cells to maintain testicular homeostatic balance

Journal of Biological Chemistry Donghui Yang, Wenbo Chen, Ning Zhang et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110221

ABHD18 degrades cardiolipin by stepwise hydrolysis of fatty acids

Journal of Biological Chemistry Mindong Ren, Shiyu Chen, Miriam L. Greenberg et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110237

Opportunities and challenges for MRD assessment in the clinical management of multiple myeloma

Nature Reviews Clinical Oncology Bruno Paiva, Qian Shi, Noemi Puig et al. Jun 01, 2025 DOI: 10.1038/s41571-025-01017-x

Endocytosis of sialic acid Neu5Gc and elevated p53 contributes to preimplantation embryonic arrest during in vitro fertilization

Journal of Biological Chemistry Xin Yuan, Yilun Wu, Yi Zhang et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110254

HER2 testing: evolution and update for a companion diagnostic assay

Nature Reviews Clinical Oncology Charles J. Robbins, Katherine M. Bates, David L. Rimm Jun 01, 2025 DOI: 10.1038/s41571-025-01016-y

Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer

Journal of Biological Chemistry Krishanu Bhowmick, Xiaochun Yang, Taj Mohammad et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108559

Epidemiology, pathogenesis, biology and evolving management of MSI-H/dMMR cancers

Nature Reviews Clinical Oncology Margherita Ambrosini, Paolo Manca, Vincenzo Nasca et al. Jun 01, 2025 DOI: 10.1038/s41571-025-01015-z

Structure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii

Journal of Biological Chemistry William S. Stuart, Christopher H. Jenkins, Philip M. Ireland et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108517

Impact of an oxidative RNA lesion on in vitro replication catalyzed by SARS-CoV-2 RNA-dependent RNA polymerase

Journal of Biological Chemistry Masataka Akagawa, Kaoru Sugasawa, Kiyoe Ura et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108512

Damage-associated molecular patterns (DAMPs) in vascular diseases

Journal of Biological Chemistry Jacob Antonello, Partha Roy Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110241

Constitutively active Arabidopsis cryptochrome 2 alleles identified using yeast selection and deep mutational scanning

Journal of Biological Chemistry Amir Taslimi, Axel Jeibmann, Lukas Goett-Zink et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110265

The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor trafficking

Journal of Biological Chemistry Tyler Couch, Tyler W. McCullock, David M. MacLean Jun 01, 2025 DOI: 10.1016/j.jbc.2025.108569

ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis

Journal of Biological Chemistry TianTian Lu, Saori Umeshita, Kae Imanishi et al. Jun 01, 2025 DOI: 10.1016/j.jbc.2025.110236