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Synergistic integration of regional and systemic therapies in uveal melanoma
Parasite-specific essential bromodomain protein TgBDP4 is a key epigenetic reader and a potential drug target for the parasite Toxoplasma gondii
Correspondence on “Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase Into an Air‐Viable Enzyme Through Multilayered Sealing of O <sub>2</sub> Tunnels”
ABSTRACT In their recent communication in Angewandte Chemie ( 10.1002/anie.202508565 ), Suk Min Kim and coworkers have described the effect of modifying the gas channels of the CO dehydrogenase II from Carboxydothermus hydrogenoformans , an enzyme that oxidizes reversibly CO into CO 2 . Their goal was to use mutagenesis to slow down the arrival of O 2 at the active site. They reported a large increase in the resistance against oxygen, one of the major barriers to the application of this extremely fast and efficient enzyme in biotechnological devices, with an increase in the IC 50 of more than two orders of magnitudes for some variants, with only a minor impact on the affinity of the enzyme for CO. We have produced the same variants, and characterized them in depth using Protein Film Electrochemistry. We used an approach that has proven very useful to learn and understand about the reactivity of CO dehydrogenases (and other redox enzymes like hydrogenases) with O 2 . We found that, contrary to the claims by Kim and coworkers, the A559W and the A559W/V610H mutants are not more resistant than the wild type against oxygen.
Superclonal expansion and barley yellow dwarf virus transmission failure in invasive Metopolophium festucae cerealium
Abstract Biological invasions can influence ecosystems, yet the evolutionary trajectories and disease dynamics of clonal expansion remain poorly understood. Since its 2011 detection, Metopolophium festucae cerealium (Stroyan), a subspecies of the cereal grass aphid endemic to Europe, has expanded across small grain growing regions of the western U.S. Our field surveys further indicate continued range expansion into previously unreported areas. Here, we integrate population genomics with virus transmission assays to evaluate its invasion structure and potential role in barley yellow dwarf virus (BYDV) transmission. Genome-wide SNP analysis of 262 individuals from six states reveals high genetic homogeneity, supporting a single introduction event and subsequent superclonal expansion. Although M. f. cerealium acquires BYDV at rates comparable to native Rhopalosiphum padi and maintains similar viral titers, it fails to transmit the virus. The primary agroecological risk posed by this invasion is through direct feeding injury, underscoring the need for continued monitoring and refined pest management strategies.