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Breakthrough therapy designations in China and the United States

Chromatin deactivation in pregranulosa cells contributes to primordial follicle formation

Electrochemically Mediated Atom Transfer Radical Polymerization Employing Rapid Alternating Polarity

Functional ultrasound neuroimaging reveals mesoscopic organization of saccades in the lateral intraparietal area

Abstract The lateral intraparietal cortex (LIP), contained within the posterior parietal cortex (PPC), is crucial for transforming spatial information into saccadic eye movements, yet its functional organization for movement direction remains unclear. Here, we used functional ultrasound imaging (fUSI), a technique with high sensitivity, large spatial coverage, and good spatial resolution, to map movement direction encoding across the PPC by recording local changes in cerebral blood volume within PPC as two male monkeys performed memory-guided saccades. Our analysis revealed a heterogeneous organization where small patches of neighboring LIP cortex encoded different directions. These subregions demonstrated consistent tuning across several months to years. A rough topography emerged where anterior LIP represented more contralateral downward movements and posterior LIP represented more contralateral upward movements. These results address two fundamental gaps in our understanding of LIP’s functional organization: the neighborhood organization of patches and the stability of these populations across long periods of time. By tracking LIP populations over extended periods, we developed mesoscopic maps of direction specificity previously unattainable with fMRI or electrophysiology methods.

PCF-VAE: posterior collapse free variational autoencoder for de novo drug design

Novel drug candidates for hard-to-treat hypertension vie for blockbuster positioning

Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation

Controlled Electron Transfer: Implementing a Reservoir-Pump-Integrated Strategy to Develop a Type I Photosensitizer for Evoking Long-Term Tumor Immunological Memory

Decadal change of seismic structure in the Earth’s lowermost mantle

Machine learning and response surface optimization to enhance diesel engine performance using milk scum biodiesel with alumina nanoparticles

FDA approves anti-prekallikrein drug for hereditary angioedema

Cysteine redoxome landscape in the liver of male mice fed a high-fat high-sucrose diet

Phase-Regulatable Synthesis of Single-Atom Alloy Nanocages for Efficient Alkaline Hydrogen Evolution

Twisted bilayer Ice as a new class of hydrogen-bonding moiré materials

Observations of successive CMEs and their successive Type II solar radio bursts in the corona

First protease activator secures FDA approval for rare brain cancer

Defined media reveal the essential role of lipid scavenging in supporting cancer cell proliferation

High-Entropy Electrolytes Downsizing Solvated Clusters and Enabling Parallel Ion Transport for Low-Temperature Aqueous Zinc Batteries

In-situ boundary bridging unlocks multi-grain-domain carrier diffusion in polycrystalline metal halide perovskites

Exploring the novel paper wasp (Parapolybia escalerae) honey for green synthesis of silver nanoparticles with antibacterial properties