Browse Articles

Construction of a <i>De Novo</i> Nucleotide Biosynthesis Pathway in Artificial Cells for RNA Transcription

Saltations of cis-regulatory modules in Canidae and Hominidae

Abstract Dogs, which were segregated from wolves about thirty thousand years ago, show unique human-similar social-cognitive abilities. However, the genomic basis accounting for the phenotypic saltation between dog and wolf remains unclear. We performed a comparative analysis of genome-wide cis-regulatory element frequencies (CREF) for five canids: dog, dingo, red fox, dhole, and wolf, along with four hominids. For each species, genome-wide CREFs are organized into a matrix. The species-specific CREF matrix is stratified into multiple dual eigen-modules through robust singular value decomposition. Cross-species comparisons of dual eigen-modules demonstrated that the top three eigen-modules are highly conserved while the fourth and fifth ones underwent a saltation in dogs. The red fox is closest to the degenerate point characterizing the onset of saltation. Gene enrichment analysis and motif analysis revealed that myelination, long-term memory, and cochlear development are significantly enhanced at level four in both humans and dogs, but not in wolves. Cross-family comparisons revealed a more similar cognition-memory module between humans and dogs than between humans and chimpanzees. Not only the presence of cis-elements but also their frequencies are crucial for deciphering the regulatory saltations that characterize a striking convergent evolution of dogs and humans in proximal regulatory sequences.

Achieving Efficient Electrocatalytic CO₂-Involved N-Methylation on Cu–Ni–Al Heterostructured Catalysts

An intelligence technique for route distance minimization to store and marketize the crop using computational optimization algorithms

Highly efficient deep-blue LED devices made using hybrid copper–iodide compound

From Molecular Dynamics to the Conductivity of Sulfuric Acid: Ultrafast Optical Kerr Effect Experiments and Ab Initio Molecular Dynamics Simulations

HDL cholesterol as a mediator of the relationship between breastfeeding and coronary atherosclerosis from a two-step Mendelian randomization analysis

<i>Remote</i> -Markovnikov Hydrobromination and Hydrochlorination of Allyl Carboxylates via Dual Photoredox/Cobalt Catalysis

Revolutionizing clinical decision making through deep learning and topic modeling for pathway optimization

New hope for Alzheimer’s: lithium supplement reverses memory loss in mice

Facilitating Anodic Ammonia Oxidation over Trace Cobalt-Substituted Solid Solution of Platinum to Boost Direct Ammonia Fuel Cell up to 853.75 mW cm^–2

Confinement of charge carriers in gapped bilayer graphene within magnetic and electrostatic barriers

Local Cation-Ordered Superlattice Stabilizing Ni-Rich Single-Crystalline Cathodes

Bioprospecting of six polyphenol-rich Mediterranean wild edible plants reveals antioxidant, antibiofilm and bactericidal properties against Methicillin resistant Staphylococcus aureus

BNB-Modified Perylene, Terrylene, and Quaterrylene Diimides: Introduction of the π-Accepting and Aggregation-Suppressing Diborinic Imide Group in Rylene Dyes

Alzheimer’s disease risk prediction using machine learning for survival analysis with a comorbidity-based approach

Uncovering the Pressure-Dependent Mechanism of CO₂ Hydrogenation to Methanol on Ga-Promoted Cu/ZrO₂ Using <i>Operando</i> Modulation-Excitation DRIFTS

Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network

Parent-of-origin effects found for gene variants that affect human growth and metabolism

Design and Synthesis of Hetero-Bicephalic Detergents for Native Mass Spectrometry of Membrane Proteins