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Zearalenone and nanozeolite improve Arugula (Eruca sativa) drought tolerance by enhancing photosynthesis and water relations
The effect of cooling rate and content of niobium on the structure, wear and corrosion resistance of CoCrFeNiNbx high entropy alloys
Abstract In this work, CoCrFeNiNbx (x = 0.25, 0.45 and 0.65) high entropy alloys were prepared by two different methods to determine the effect of cooling rate and the niobium content on the structure and properties of ingots and plates. The structure was investigated extensively using X-ray diffraction, scanning electron microscopy, and Mössbauer spectroscopy. The results confirmed the dual-phase structure, consisting of the FCC solid solution and the Laves phase. The increase in niobium content changed the microstructure from hypoeutectic (x = 0.25 and 0.45) to hypereutectic (x = 0.65). The high cooling rate during solidification from the liquid state enabled the formation of ultrafine eutectic structures with an average lamellae thickness of only 130 ± 9 nm in the CoCrFeNiNb0.65 plate. The corrosion behaviour of the alloys was studied in solutions of 3.5% NaCl and 3.5% NaCl + H3BO3. The beneficial effect of increasing the niobium content in as-cast CoCrFeNiNbx alloys on the corrosion resistance was confirmed in both environments. Furthermore, the alloys solidified with a higher cooling rate exhibited a lower corrosion susceptibility in the 3.5% NaCl solution. The results of the EIS study indicated that a higher content of niobium contributed to the formation of a more stable and compact passivation layer. The hardness of the CoCrFeNiNbx alloys increased with a higher niobium content, achieving the highest value of 669 HV1 for the CoCrFeNiNb0.65 plate. The increase in the cooling rate positively affected the tribological properties of the CoCrFeNiNbx alloys, contributing to the decrease in the friction coefficient for the CoCrFeNiNb0.25 and CoCrFeNiNb0.45 plates.
Identification of Ni–N<sub>4</sub> Active Sites in Atomically Dispersed Ni Catalysts for Efficient Chlorine Evolution Reaction
Development and validation of a CT-measured body composition radiomics model for prognostic assessment in resected pancreatic adenocarcinoma
A comprehensive study on the impact of He ion irradiation on the microstructure and mechanical properties of a Ni-Cr-Mo alloy
Contrastive representation learning with transformers for robust auditory EEG decoding
Glial fibrillary acidic protein in plasma and intraocular fluids and the correlation with cognitive function in patients with vitreoretinal disease
Direct Cellular Screening of Pd-Mediated Arylation of Cyclic Peptide Binders Targeting Ubiquitin Chains: Toward Modulating NEMO Liquid–Liquid Phase Separation
Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways
A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo
Multiscale investigation of thermally activated coal gangue aggregate concrete interfacial transition zone evolution and failure mechanisms
Ultra-Narrow Homogeneous Photoluminescence Line Width of Zinc-Blende CdSe-Based Core/Shell Nanocrystals: Dominating Role of Lattice–Ligands Interface
In silico decrypting of the bystander effect in antibody–drug conjugates for breast cancer therapy
Abstract Antibody–Drug Conjugates (ADCs) are a promising cancer treatment that deliver toxic drugs directly to cancer cells, reducing harm to healthy tissue. A key feature of newer ADCs is the “bystander effect,” in which nearby cancer cells are also affected by passive diffusion. However, the mechanisms underlying this effect remain unclear. Using computer simulations, this study investigates how the drug’s ionization state and the linker connecting it to the antibody influence its ability to cross cell membranes. The results show that the ionization state of the drug impacts its membrane permeability, as charged molecules encounter resistance when moving through the membrane’s hydrophobic core. Moreover, the study reveals that the linker increases the drug’s overall size and hydrophobicity, thereby hindering its diffusion to adjacent cells. This finding suggests that linker design can significantly influence the efficacy of antibody–drug conjugates (ADCs) by limiting their ability to reach neighboring cancer cells. These insights enhance our understanding of ADC mechanisms and provide a valuable foundation for the optimization of next-generation ADC therapies targeting breast cancer.