A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo

W Wei Zhang L Lizhen Yuan (State Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry) R Rui Liu Y Yanbo Jing (State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences) S Shijun Lin (State Key Laboratory of Geomicrobiology and Environmental Changes, Faculty of Materials Science and Chemistry) H Hao Fang (Interdisciplinary Materials Research Center, School of Materials Science and Engineering) Y Yuxuan Li (Hefei National Research Center for Physical Sciences at the Microscale) X Xiaohui Zhang J Jun Dai T Tao Liu F Fan Xia X Xiaoding Lou (State Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry)

Article Details

Volume / Issue Vol. 147, Issue 31
Published August 06, 2025
Pages 27862-27875
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

W

Wei Zhang

L

Lizhen Yuan

State Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry

R

Rui Liu

Y

Yanbo Jing

State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences

S

Shijun Lin

State Key Laboratory of Geomicrobiology and Environmental Changes, Faculty of Materials Science and Chemistry

H

Hao Fang

Interdisciplinary Materials Research Center, School of Materials Science and Engineering

Y

Yuxuan Li

Hefei National Research Center for Physical Sciences at the Microscale

X

Xiaohui Zhang

J

Jun Dai

T

Tao Liu

F

Fan Xia

X

Xiaoding Lou

State Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry