Browse Articles

Radiomics Quality Score 2.0: towards radiomics readiness levels and clinical translation for personalized medicine

Nature Reviews Clinical Oncology Philippe Lambin, Henry C. Woodruff, Shruti Atul Mali et al. Nov 01, 2025 DOI: 10.1038/s41571-025-01067-1

Loss of TRIM44 promotes renal cell carcinoma progression by regulating K48-linked ubiquitination of vimentin

Journal of Biological Chemistry Ke Shi, Baiyun Jia, Yuanyu Li et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110734

Apoptosis-targeting BH3 mimetics: transforming treatment for patients with acute myeloid leukaemia

Nature Reviews Clinical Oncology Antonino Glaviano, Ellen Weisberg, Hiu Y. Lam et al. Nov 01, 2025 DOI: 10.1038/s41571-025-01068-0

Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase

Journal of Biological Chemistry Eric Z. Pang, Boyu Zhao, Cameron Flowers et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110735

Differential modulation of polycystin-2 gain-of-function channels by cysteine-reactive compounds, amphiphilic substances, and S4-S5 linker mutations

Journal of Biological Chemistry Linda Geiges, Tobias Staudner, Juthamas Khamseekaew et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110766

APP family is a regulator of endo-lysosomal membrane vulnerability

Journal of Biological Chemistry Brianna Lundin, Natalia Wieckiewicz, Midori Yokomizo et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110774

Treatment of NSCLC after chemoimmunotherapy — are we making headway?

Nature Reviews Clinical Oncology Martin Reck, Nikolaj Frost, Solange Peters et al. Nov 01, 2025 DOI: 10.1038/s41571-025-01061-7

Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1)

Journal of Biological Chemistry Dong Yan Zhang, Jian Wang, Gangtong Huang et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110778

The complex network of p300/CBP regulation: Interactions, posttranslational modifications, and therapeutic implications

Journal of Biological Chemistry Ebru Yazıcı, Justyna McIntyre Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110715

SERENA-6: dynamic ctDNA assessment and the future of precision cancer medicine

Nature Reviews Clinical Oncology Arielle J. Medford, Seth A. Wander Nov 01, 2025 DOI: 10.1038/s41571-025-01066-2

Generation of NADPH and the formation of lipofuscin fluorophore precursors in human rod photoreceptors

Journal of Biological Chemistry Leopold Adler, Chunhe Chen, Nicholas P. Boyer et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110802

Surprising role of CMV in shaping outcomes of immunotherapy for melanoma — chronic infection yields favourable survival

Nature Reviews Clinical Oncology Anthony R. Cillo, John M. Kirkwood Nov 01, 2025 DOI: 10.1038/s41571-025-01065-3

Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids

Journal of Biological Chemistry Matthew L. Edin, Joan P. Graves, Darryl C. Zeldin Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110737

USP52 inhibits cell ferroptosis via Hippo–YAP pathway and blocks immunotherapy in colorectal cancer

Journal of Biological Chemistry Jingkai Zhou, Haihang Nie, Chenhui Liu et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110725

NR4A1 is a HIF-dependent repressor of SLC30A10 transcription that controls manganese homeostasis

Journal of Biological Chemistry Noah R. Haggerty, Yeo Rang Lee, Nishant Sharma et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110707

Embracing the avoid-ome

Nature Reviews Drug Discovery Asher Mullard Nov 01, 2025 DOI: 10.1038/d41573-025-00169-w

UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress

Journal of Biological Chemistry Barbora Lubyova, Eva Tikalova, Vaclav Janovec et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110750

FDA new drug approvals in Q3 2025

Nature Reviews Drug Discovery Paul Verdin Nov 01, 2025 DOI: 10.1038/d41573-025-00170-3

Surface emergence and persistence of MHC class I free heavy chains

Journal of Biological Chemistry Fernando M. Ruggiero, François-Xavier Mauvais, Ursula Wellbrock et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110799

Innovation in medicines for global health: a 20-year landscape analysis

Nature Reviews Drug Discovery Paul Ashigbie, Rajiv Shah, Thierry Diagana et al. Nov 01, 2025 DOI: 10.1038/d41573-025-00164-1