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Discover research articles across all indexed journals

Biogeographic barriers and environmental gradients reveal distribution limits in Hynobius salamanders

Scientific Reports Tae Eun Um, Desiree Andersen Bliss, Amaël Borzée et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22226-5

New deep sea terebellid polychaete with sucker like ventral pads adapted to a sediment free environment

Scientific Reports Naoto Jimi, Geminne G. Manzano, Natsumi Hookabe et al. Nov 03, 2025 DOI: 10.1038/s41598-025-23333-z

Enhanced skin cancer classification using modified efficientNetV2L with adaptive early stopping mechanism

Scientific Reports Chandrasekar Venkatachalam, Shanmugavalli Venkatachalam, Arunkumar Balakrishnan Nov 03, 2025 DOI: 10.1038/s41598-025-22228-3

Abstract The accurate classification of skin cancer types is a critical task in medical diagnostics, requiring robust and reliable models to distinguish between various skin lesions. Despite advancements in deep learning, developing models that generalize well to unseen data remains a challenge. Current methodologies primarily utilize convolutional neural networks (CNNs) for image classification tasks, leveraging architectures such as ResNet, VGG, and Inception. These models have shown promise in improving classification accuracy for skin cancer detection. However, existing models often face limitations, including overfitting to the training data and difficulty in handling imbalanced datasets. This results in decreased performance on validation and test datasets, reducing their practical applicability in clinical settings. Additionally, these models may lack the fine-grained discrimination required to accurately classify a diverse range of skin lesion types. To address the limitations of traditional CNN-based approaches, we propose a novel model based on the EfficientNetV2L architecture, optimized for skin lesion classification. Our approach introduces adaptive early stopping and learning rate callbacks to enhance generalization and prevent overfitting. Trained on the ISIC dataset, the model achieved a high classification accuracy of 99.22%, demonstrating robustness across various lesion types. This work contributes a powerful, efficient, and clinically relevant solution to the field of automated skin cancer diagnosis.

Daily briefing: Custom-made gene-editing therapy for children to enter clinical trial

Nature Flora Graham Nov 03, 2025 DOI: 10.1038/d41586-025-03619-y

Graph-augmented multi-modal learning framework for robust android malware detection

Scientific Reports Muhammad Usama Tanveer, Kashif Munir, Hasan J. Alyamani et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22169-x

Fraudulent account detection in social media using hybrid deep transformer model and hyperparameter optimization

Scientific Reports Prashant Kumar Shukla, Bala Dhandayuthapani Veerasamy, Noha Alduaiji et al. Nov 03, 2025 DOI: 10.1038/s41598-025-24326-8

OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist

Scientific Reports Gregory M. Young, Timothy H. Helms, Samuel K. Kulp et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22258-x

Investigation of floor blasting for rock burst prevention in high-stress roadway under dynamic loading

Scientific Reports Geng Li, Anye Cao, Guifeng Wang et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22325-3

Increased autoantibodies against incretin indicate poor prognosis in patients with diabetes

Scientific Reports Minoru Takemoto, Bo-Shi Zhang, Aiko Hayashi et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22337-z

HyFusion-X: hybrid deep and traditional feature fusion with ensemble classifiers for breast cancer detection using mammogram and ultrasound images

Scientific Reports Anum Shaukat, Saima Farhan, Rabia Javed et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22262-1

Differential effects of KRAS G-domain and hypervariable region mutants on cancer phenotypes

Scientific Reports James Allen D. de Borja, Kim Denyse J. Hao Lin, Daniel Angelo R. Mirador et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22168-y

Ensemble machine learning models for predicting strength of concrete with foundry sand and coal bottom ash as fine aggregate replacements

Scientific Reports Sagar Paruthi, Rashmi Verma, Neha Sharma et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22212-x

Depression in mice causes decreased neuronal excitability and enhanced frequency adaptation in medial prefrontal cortex pyramidal neurons

Scientific Reports Anita Maria Rominto, Francesca Montarolo, Luna Berrino et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22321-7

Exploring the relationship between boredom proneness and short-form videos addiction among Chinese college students through a moderated mediation model

Scientific Reports Zihao Wan, Mengru Guo, Chi Yang et al. Nov 03, 2025 DOI: 10.1038/s41598-025-22313-7

Abstract Previous studies have shown positive associations between boredom proneness and mobile phone addiction. However, the association between boredom proneness and short-form video addiction (SFVA), as well as the intermediate psychological mechanisms, remain unclear. This study aimed to investigate the correlation between boredom proneness and subsequent SFVA among Chinese college students and to examine the mediating role of fear of missing out and the moderating role of intolerance of uncertainty. A total of 458 college students (62.2% male; M age = 19.17) from a university in central China participated in a two-wave time-lagged study with six months intervals. Results showed that boredom proneness was positively associated with SFVA six months later. Fear of missing out mediated this association, and intolerance of uncertainty moderated the association between boredom proneness and fear of missing out. The results further showed that the indirect effect of boredom proneness on SFVA via fear of missing out was more salient when there was a higher levels of intolerance of uncertainty. Interventions targeting boredom proneness and intolerance of uncertainty may be important in addressing SFVA in college populations.

Regulation of inflammatory processes by caspases

Nature Reviews Molecular Cell Biology Manuel Beltrán-Visiedo, Ruth Soler-Agesta, Kristopher A. Sarosiek et al. Nov 01, 2025 DOI: 10.1038/s41580-025-00869-6

The deacetylase NagA mediates the remodeling and recycling of peptidoglycan-derived amino sugars in mycobacteria

Journal of Biological Chemistry Collette S. Guy, Charlotte Cooper, Magdalena Karlikowska et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110597

Transmembrane domain interactions underlie NSG1 regulation of sortilin ectodomain shedding

Journal of Biological Chemistry Malene Overby, Lasse Messell Desdorf, Lisbeth Kjølbye et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110804

Death, taxes, and rhomboids: Understanding the ubiquitous roles of the rhomboid protein superfamily

Journal of Biological Chemistry Henry Sawczyc, Spyridon Kosteletos, Adam Lange Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110699

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins

Journal of Biological Chemistry Julius Martinkus, Laurent Terradot, Dukas Jurėnas et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110775

A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis

Journal of Biological Chemistry Annika Behrendt, Alex Bastianelli, Jan Stindt et al. Nov 01, 2025 DOI: 10.1016/j.jbc.2025.110769