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Baker’s Cyst
Cause of vision loss discovered in overlooked genes
Synergistic tribo-mechanical enhancement of heat-cured poly(methyl methacrylate) denture base via hybrid in-situ synthesized organic and inorganic nanoparticles
Abstract Poly(methyl methacrylate) (PMMA) is the primary material for dental applications, but it suffers from limitations such as poor wear resistance and long-term durability. To address these shortcomings, this work presents a new and cost-effective hybrid nanofiller system comprising hydroxyapatite (inorganic nanoparticles) and date seed (organic nanoparticles) for reinforcing PMMA denture bases. This study specifically investigates the reinforcement of heat-polymerized PMMA with this new hybrid nanofiller. Comprehensive material characterization was performed using XRD, DSC, SEM, TEM, and EDX. The findings demonstrate that PMMA composites with 0.2-1 wt% hybrid nanoparticles, particularly at 0.6 wt%, showed enhanced mechanical and tribological performance compared to the pure polymer. Specific improvements included a 30.99% decrease in the coefficient of friction, a 37.39% reduction in wear rate, a 31.92% increase in compressive strength, and a 9.87% improvement in surface hardness.
Mental Health Outcomes in Children after Parental Firearm Injury
Patient-level CAD-RADS scoring from coronary radiomic features
Canny cattle: at least one cow knows how to use tools
Porphyrin-nitrogen carbon dot composites for high-performance organic light-emitting diodes
Abstract Fluorescent organic light-emitting diodes (OLEDs) still face major obstacles to combining high efficiency with solution processability and energy-sustainable operation. In this work, a tetra-carboxyphenyl porphyrin–nitrogen carbon dots (TCPP-NCDots) derivative is introduced as a solution-processable electron transport layer (ETL) in OLEDs based on a green–yellow emissive polymer. The structural, optical, and electronic properties of the TCPP-NCDots ETL are comprehensively characterised by ultraviolet–visible absorption spectroscopy, steady-state photoluminescence, Fourier-transform infrared spectroscopy, atomic force microscopy, and cyclic voltammetry. These studies reveal a synergistic effect of porphyrin functionalisation on the carbon dots, which improves electron injection and transport toward the emissive layer. At an optimum concentration of 1 mg mL −1 , the TCPP-NCDots ETL yields a 21.6% enhancement in external quantum efficiency compared with the reference device without an ETL, while simultaneously suppressing efficiency roll-off. The optimised devices also maintain stable operation under ambient conditions, highlighting TCPP-NCDots as a promising, sustainable ETL platform for next-generation fluorescent OLEDs.
A recyclable dendrimeric Ni nanocatalyst anchored on magnetic nanoparticles for the green reduction of nitroarene pollutants and one-pot synthesis of imines
Fast-powerformer achieves accurate and memory-efficient mid-term wind power forecasting
Body condition among Svalbard Polar bears Ursus maritimus during a period of rapid loss of sea ice
Abstract Polar bears are only found in Arctic areas with sufficient access to sea ice and seals on which they prey. Studies have highlighted negative effects on condition and demographics in areas where sea ice cover is declining due to warmer climate, but condition of the Barents Sea polar bear population have not been examined yet. Loss of sea ice rate has been considerably higher here than in other areas with polar bears. We investigated variation in body condition index (BCI) among 770 adult bears, 1188 captures, in March-May 1995–2019, in Svalbard, Norway (western part of the Barents Sea). We assessed how intrinsic (female reproductive state, age) and both males and females, BCI declined until 2000, but increased afterwards, during a period with rapid loss of sea ice. In models including sea ice metrics and climate (Arctic Oscillation), there was no support for the predicted negative effect of warmer weather and habitat loss. This indicates a complex relationship between habitat, ecosystem structure, energy intake, and energy expenditure. Increases in some prey species, including harbour seals, reindeer, and walrus, may partly offset reduced access to seals. Our findings underline the importance not to extrapolate findings across populations.
Optimization of the extraction process of Sanhuang Qingre Formula by integrating response surface methodology, grey correlation analysis, and machine learning
A comparative evaluation of time-series models for forecasting inpatient deaths and discharges against medical advice
Evaluation and correlation of heart rate variability and ventricular repolarization parameters in an Indian pediatric clinical hypothyroid population: a prospective cohort study
Abstract To compare ventricular repolarization and heart rate variability in hypothyroid and healthy children and to assess the effects of levothyroxine therapy on cardiac electrophysiological and autonomic parameters. This study investigated ventricular repolarization parameters and heart rate variability (HRV) in hypothyroid children (5–12 years) compared with age-matched healthy controls and patients before and after thyroxine treatment. This study included 64 participants divided into hypothyroid and healthy groups (32 each). Parameters such as the Tpe interval, QT interval, and HRV indices were measured via standard electrocardiographic and HRV analysis techniques. Thyroid hormone levels were measured. Post treatment measurements were also performed on hypothyroid children following 3 months of levothyroxine therapy. Hypothyroid children presented significantly prolonged Tpe intervals (58.07 ± 9.21 ms vs. 53.80 ± 8.89 ms, p = 0.039), reflecting increased heterogeneity in ventricular repolarization. HRV analysis revealed decreased parasympathetic modulation (e.g., lower RMSSD and pNN50 values) in hypothyroid participants. Posttreatment improvements in HRV indices and thyroid hormone levels correlated with normalization of cardiac electrophysiological parameters. This study highlights that even mild thyroid dysfunction in children can subtly disrupt cardiac electrical stability and autonomic balance which may increase the risk of arrhythmia in this population. Timely thyroxine therapy not only restores thyroid levels but also powerfully rebalances the electrical and autonomic balance of the heart. These findings reaffirm the critical need for early detection and proactive treatment of pediatric hypothyroidism to safeguard lifelong cardiovascular health.
Ultra-high resolution OCT imaging reveals retinal layer degeneration in RD10 mice with comparison to commercial standard resolution OCT
Content style decoupling for multi style image generation using latent diffusion architecture
Mixing regimes shape microbial community composition, nutrient regimes, and plant growth attributes in Jeevamrit: metagenomics and culturomics-based insights
Commonalities and distinctions of static and dynamic functional connectivity density between left and right temporal lobe epilepsy
Real-world performance of the AI diagnostic system IDx-DR in the diagnosis of diabetic retinopathy and its main confounders
Abstract The escalating prevalence of diabetes mellitus (DM) emphasizes the critical need for early detection of diabetic retinopathy (DR). This study assesses the performance of the autonomous AI-based diagnostic system IDx-DR in detecting DR and its associated confounders in a real-world clinical setting. This prospective cross-sectional study involved 875 diabetic patients with a mean age of 52 years (range: 8–92). Retinal images were captured by trained assistants. IDx-DR results were compared with mydriatic fundus examination (gold standard) and Ophthalmologists’ image analysis. Factors impacting image acquisition or analyzability were examined. Among all patients, 10.5% yielded no image in miosis, and 26.1% were unanalyzable by IDx-DR. Confounders affecting image acquisition were examiner, pupil size, patient age and patients’ visual acuity. When good quality images were achieved, IDx-DR performed well, particularly in detection of severe DR (sensitivity 94.4%; specificity 90.5%). IDx-DR results exactly matched Ophthalmologists’ mydriatic fundoscopy gradings in 54.2% if images of sufficient quality were obtainable. Undergrading of DR severity by IDx-DR was rare (4.8%). IDx-DR shows promise in detecting DR, especially in resource-limited settings and in detecting severe DR. One remaining challenge is good image acquisition in miotic patients.