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Oncogenic Ras drives EED degradation and PRC2 dysfunction to promote aggressive squamous cell carcinoma
Thermally induced volumetric response of natural clays: effects of OCR, plasticity, and recent stress history
Abstract Understanding the thermally induced volumetric response of fine-grained soils is important for geo-energy systems, underground storage facilities, and radioactive waste repositories. This study examines the thermo-mechanical response of two natural silty clays from Budapest, Hungary, with different plasticity levels and stress histories. Slow-heating tests under drainage-promoting boundary conditions and heating–cooling cycle tests were performed using a temperature-controlled oedometer on low-plasticity (LP) and high-plasticity (HP) samples. The specimens were heated from $$25~^\circ \textrm{C}$$ to $$85~^\circ \textrm{C}$$ under different over-consolidation ratios, ranging from OCR = 1 to 22. The results show that normally consolidated samples contract during slow heating. Overconsolidated samples show a more variable response, indicating that OCR alone is not sufficient to describe the thermal volumetric behaviour. The HP samples generally developed larger thermal volumetric strains than the LP samples, showing the influence of plasticity on the magnitude of thermal deformation. The low-stress naturally overconsolidated specimens, LP12 and HP22, showed mainly contractive behaviour, although their response should be interpreted with caution because their OCR values were inferred from apparent preconsolidation pressures obtained from separate room-temperature oedometer tests. During repeated heating–cooling cycles, most irreversible volumetric strain developed during the first cycle, while later cycles showed smaller strain increments and a trend towards more recoverable behaviour. The tests were not independently verified as fully drained by pore-pressure measurements; therefore, the results are interpreted as laboratory-scale evidence under drainage-promoting conditions rather than as proof of a unique drained mechanism.
Hierarchical nano-orderings enable extraordinary cryogenic strength-ductility synergy in a medium-entropy alloy
Green buildings in the malaysian construction industry: barriers in implementation
A small nucleolar RNA dictates the structure and function of translating ribosomes in Leishmania
Factors influencing the adoption of biosecurity practices in livestock farming in bangladesh for infectious disease prevention
A plastoglobuli-localized enzyme links phenylalanine biosynthesis to translational homeostasis in maize
Green Synthesis of ZnO-CuO nanocomposite using Annona reticulata leaf extract for antibacterial, seed germination, and protein interaction studies
Antibody reveals conformational latch regulating dimerization in β- and γ-herpesvirus proteases
Abstract Human herpesvirus (HHV) replication depends on the HHV protease (HHV Pr), an enzyme essential for capsid maturation. Because HHV Pr must transition from an inactive monomer to an active dimer, disrupting dimerization is a promising antiviral strategy. We isolate Fab5, a conformationally selective antibody from a naïve Fab-phage library that recognizes monomeric human cytomegalovirus protease (HCMV) Pr. A 2.6 Å cryo-EM structure reveals Fab5 binds a “latch loop” distal to the active site and dimer interface that secures the C-terminal tail in dimers. Structure-guided mutagenesis in both HCMV Pr and Kaposi’s Sarcoma-associated herpesvirus (KSHV) Pr confirms the functional importance of a 3-residue motif present in β- and γ-HHV Pr latch loops, validating the mechanistic role of the latch loop in dimerization and activity. Because the latch loop is structurally conserved in all HHV Prs, the cryptic sites they form present an avenue for allosteric inhibitor development.
Performance of large language models in a high-stakes dental assessment: evidence from the Turkish dentistry specialization examination
Crossover between intrinsic and temperature-assisted regimes in spin-orbit torque switching of antiferromagnetic order
Gastrointestinal Helicobacter pylori infection is associated with reproductive tract HPV prevalence in a propensity score-matched cross-sectional study of 7734 women
Temporal self-similarity reveals percolation universality classes in complex networks
Effects of guanidinoacetic acid and live yeast cells on cattle rumen fermentation and greenhouse biogas production in vitro of ten shrub species
Dietary intervention and BMI reduction in individuals at the extremes of genetic predisposition to higher BMI: a randomized controlled trial
Association of early anion gap with 28-day mortality: a landmark cohort study in MIMIC-IV with multicenter validation in eICU-CRD
A quantitative approach for defining the degradability landscape of protein degraders
Treefall risk assessment in an urban green area for a hypothetical 30-year return period storm using damage data from Typhoons Faxai and Hagibis in 2019
Abstract Urban trees support human well-being, yet their benefits must be balanced against the risk of tree failure. Here, we propose a simple quantitative approach that practitioners can use to assess and manage urban treefall risk. We developed a simple mechanical model based on readily measured trunk diameter and height to calculate a hypothetical maximum compressive stress in the trunk for a given wind speed. This stress-based index was treated as a latent variable linking the mechanical and stochastic components of our framework. We then fitted a statistical model that predicts treefall probability from the latent stress index using empirically observed treefall records from Typhoons Faxai and Hagibis (2019). Unmodeled sources of variability and other unaccounted-for factors were implicitly incorporated through statistical calibration. The fitted model showed a statistically supported association between the latent stress index and treefall probability (broadleaved tree AUC = 0.94, conifer AUC = 0.77). Using extreme value analysis, we estimated the 30-year return level of maximum wind speed at the study site and assessed treefall risk for individual trees under this scenario. The model indicated higher risk for tall non-native trees (relative to local native species) and for conifers. Although available treefall data remain limited, to our knowledge, this study is among the first to predict future treefall probability using empirically observed treefall records and to provide a quantitative framework for practitioners to manage treefall risk.
Racial and economic disparities in coastal access and engagement mediate the ocean’s contribution to human wellbeing
Abstract Understanding what shapes ocean access and its contribution to human wellbeing is critical for equitable and sustainable marine resource management. Using a community-engaged research approach, we examine responses from 1691 surveys administered across central California (USA), an iconic coastline renowned for its biodiversity and cultural significance, to explore the factors mediating ocean use and benefits. We find that a) the ocean’s subjective and relational contributions to human wellbeing outweighed material contributions; and b) these benefits are constrained for vulnerable communities and underserved populations by personal (e.g., lack of interest or affordability), physical-environmental (e.g., lack of infrastructure or exposure to pollution), and knowledge (e.g., how to safely and legally engage) barriers. Our results highlight how structural exclusion from ocean spaces limits wellbeing for marginalized groups, a critical feedback loop that may perpetuate inequality and degrade public health. Though California considers itself a world leader in ocean management, our findings indicate that there is more work to be done and offer actionable insight for advancing more inclusive and equity-centered approaches to coastal and ocean governance.