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Luminescence meets physical unclonability in fracture engineered porous polymer skeletons for anticounterfeiting

Microbial drought resistance is achieved at the expense of soil carbon loss

SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport

Abstract Membrane transporters and channels are generally assumed to be based on distinct structural and functional principles. SLC26A11, a solute carrier with high expression levels in the brain, has been proposed to function as either an anion transporter or a channel. Here, we resolve this apparent discrepancy by demonstrating that SLC26A11 is a dual-function protein capable of operating as both a sulfate transporter and a chloride channel. By resolving its structure and combining biochemical studies and molecular dynamics simulations, we show that SLC26A11 exhibits all the hallmarks of a secondary transporter. The mechanistic basis for its selective ion transport identifies the protein as the elusive lysosomal sulfate exporter. Additionally, we demonstrate that SLC26A11 exhibits an uncoupled, channel-like chloride conductance gated by proton:sulfate symport. Our finding that the chloride-conducting state arises from the transport cycle may contribute to the development of therapeutic strategies for treating brain edema, and the identification of its role in lysosome sulfate efflux may provide new approaches to study and treat lysosomal storage diseases.

Universal Planckian dissipation in the strange metal state of the cuprates

Composition-Programmed Transport Inversion in Spherical Nucleic Acids across Distinct Epithelial Barriers

Genetically Encoded Pentafluorophenylalanine Enables Quantitative Probing of Local Protein Malleability by ¹⁹ F NMR

Catalytic Asymmetric Metallocyclopropanation Reactions Using Chloroform as a Carbyne Equivalent

Enantioselective Hydroarylation via Chiral Transient Directing Groups: Access to Chiral Benzo-Fused Heterocycles with Collaborative Enantiomeric Control

Noninnocent Ligands as a Design Strategy for Fully Compensated Ferrimagnetism in Two-Dimensional Metal–Organic Frameworks

Spin Manipulation Effect in Photodeprotection Reaction Using Triplet Ground-State Cation

From Energy Matching to Lifetime Control: Tunable Excited-State Equilibria in an Iron–Pyrene Dyad

Conformational Bias and Transmission Drive Structural Differentiation of Covalent Organic Frameworks

Identification of Antibacterial Cyclic Peptides with a High-Throughput Cell-Based Dropout Screen

Understanding Topochemical Microcrystal Conversion in Molten Salt to Produce High-Aspect-Ratio Perovskites Particles

From Metal–Organic Helices to Zeolite-like Supramolecular Assemblies

Activation of Oxygen Evolution Electrocatalysis via Reduced Ruthenium–Oxygen–Ruthenium Coordination

Pd ₂₄ Cu ₁₂ Cages with Open Tripalladium Nodes for Selective Hydrogenation

Molecular Motion and Connectivity Govern Mechanophore Activation in High- <i>T</i> _g Glassy Polymers

Interpenetration Control in Three-Dimensional Covalent Organic Frameworks: Architectural Modulation and <i>cis</i> -Imine Configuration

Synthetic Method–Defect Correlations in Aldol Polycondensation: From Model Reactions to an <i>n</i> -Type Thiazolothioazole Copolymer